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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5169 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 6 articles | Viewed by 3871 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3434 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2903 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2037 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1653 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 31 Jul 2026 | Viewed by 364 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Jul 2026 | Viewed by 189 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Jul 2026 | Viewed by 181 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction

edited by Namrata Anand

submission deadline 31 Jul 2026 | Viewed by 180 | Submission Open

Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction

(This special issue belongs to the Section Cellular Immunology)

ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 120 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy

Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 80 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 31 Jul 2026 | Viewed by 42 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

Molecular Mechanisms to Treatment Progress of Ovarian Cancer

edited by Amal M. El-Naggar

submission deadline 31 Jul 2026 | Viewed by 35 | Submission Open

Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research

(This special issue belongs to the Section Reproductive Cells and Development)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition

edited by Sachin Mulik, Weshely Kujur,

Engin Berber

and Sumit Sen Santara

submission deadline 31 Jul 2026 | Viewed by 32 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Sex Differences in Molecular Mechanisms Linking Neuronal Stress and Inflammation

edited by John R. Bethea and Kayla Lee Nguyen

submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open

Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Histological Classification of Lung Cells Across Animal Models and Life Stages

edited by

Roberta Ciccimarra

submission deadline 31 Jul 2026 | Viewed by 24 | Submission Open

Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing

(This special issue belongs to the Section Tissues and Organs)

Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis

edited by

Sandeep Rai Kaushik

, Pradeep Kumar Sheokand,

Nejat Düzgüneş

, Ekta Saini and Prashant Bajpai

submission deadline 31 Jul 2026 | Viewed by 22 | Submission Open

Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling

(This special issue belongs to the Section Cellular Immunology)

NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets

edited by Gaetano Spinelli and

Francesco Di Blasi

submission deadline 1 Aug 2026 | Viewed by 3 | Submission Open

Keywords: NF-κ B signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 5 Aug 2026 | Viewed by 211 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 10 Aug 2026 | 8 articles | Viewed by 20869 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 10 Aug 2026 | 1 articles | Viewed by 2697 | Submission Open

Keywords: cellular therapies; cancer; immune

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Aug 2026 | Viewed by 563 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Study on Ovarian Follicle Development

edited by Cecily V. Bishop and Jessica Cristina Lemos Motta

submission deadline 10 Aug 2026 | Viewed by 186 | Submission Open

Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Aug 2026 | 1 articles | Viewed by 3054 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation

edited by

Eugenie S. Kleinerman

and

Pradeep Shrestha

submission deadline 15 Aug 2026 | Viewed by 41 | Submission Open

Keywords: osteosarcoma; immunotherapy; biomarker

(This special issue belongs to the Section Cellular Pathology)

Autophagy-Related Proteins in Stress Responses

edited by

Aurore Claude-Taupin

submission deadline 20 Aug 2026 | Viewed by 36 | Submission Open

Keywords: stress response; ATG; endocytosis; exocytosis; autophagy

(This special issue belongs to the Section Autophagy)

New Neurons, Circuits and Functions of the Cerebellum

edited by

George Augustine

and Jinsook Kim

submission deadline 24 Aug 2026 | Viewed by 3 | Submission Open

Keywords: cerebellar neurons; cerebellar synapses; cerebellar circuit organization; cerebellar function; cerebellar disorders; cerebellar learning and behavior

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants

edited by Aziz Khan and

Xin Zhang

submission deadline 25 Aug 2026 | 2 articles | Viewed by 10005 | Submission Open

Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo

edited by

Mousumi Ghosh

submission deadline 25 Aug 2026 | Viewed by 26 | Submission Open

Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Aug 2026 | 2 articles | Viewed by 4186 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Redox Regulation by Nrf2 in Health and Disease

edited by Pandu Gangula

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1336 | Submission Open

Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response

Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes

edited by

Roshan L. Shrestha

and Subhash Chandra Sethi

submission deadline 30 Aug 2026 | Viewed by 62 | Submission Open

Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging

(This special issue belongs to the Section Cell and Gene Therapy)

Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases

edited by

Sweta Ghosh

and Subir Kumar Juin

submission deadline 31 Aug 2026 | 2 articles | Viewed by 888 | Submission Open

Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease

The Spatial and Temporal Dynamics of the Tumor Microenvironment

edited by

Shilpa Bisht

, Abhishek Gupta, Anjali Trivedi and

Alessandra Ferraresi

submission deadline 31 Aug 2026 | Viewed by 623 | Submission Open

Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches

(This special issue belongs to the Section Cell Microenvironment)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 31 Aug 2026 | Viewed by 224 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities

edited by

Mangesh Hade

submission deadline 31 Aug 2026 | Viewed by 192 | Submission Open

Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Turning Points in α-Synuclein Biology: From Function to Dysfunction

edited by

Quan Zhong

and

Ishita Haider

submission deadline 31 Aug 2026 | Viewed by 61 | Submission Open

Keywords: α -synuclein; protein aggregation; pathological conversion; synucleinopathies; Parkinson’ s disease; neurodegeneration; neurotoxicity; proteostasis; mitochondrial dysfunction; autophagy

(This special issue belongs to the Section Cellular Neuroscience)

Recent Discoveries and Progress in Central Nervous System Neuroinflammation

edited by

Johannes Boltze

submission deadline 31 Aug 2026 | Viewed by 55 | Submission Open

Keywords: autoimmune; cerebrovascular; diagnosis; immune cells; microglia; neoplastic; neurodegenerative; neuroinflammation; system interaction; therapeutic targets

(This special issue belongs to the Section Cellular Neuroscience)

Novel Insights into G-Protein-Coupled Receptor Biology: From Structure to Signaling Regulation

edited by

Bianca Fiorillo

and Bruno Catalanotti

submission deadline 31 Aug 2026 | Viewed by 44 | Submission Open

Keywords: GPCR signaling; structure– function; allosteric modulation; receptor; homology modeling; computational chemistry; AI-based prediction; signal transduction; cellular regulation

Sickle Cell Disease: Current Advances in Molecular Mechanisms and Therapeutic Strategies

edited by

Marisa Silva

and Paula Faustino

submission deadline 31 Aug 2026 | Viewed by 44 | Submission Open

Keywords: sickle cell disease; genetic modifiers; gene editing; SCD pathophysiology; SCD biomarkers; SCD treatment; SCD management

(This special issue belongs to the Section Cellular Pathology)

Building the Neurons: Cytoskeleton Dynamics and Organelle Interaction in Health and Disease

edited by Xing Liang and

Lars Ove Brandenburg

submission deadline 1 Sep 2026 | Viewed by 41 | Submission Open

Keywords: development and health of neurons; cytoskeleton dynamic; organelle interactions

(This special issue belongs to the Section Cellular Neuroscience)

Lipid Homeostasis in Health and Disease

edited by

Vitor Teixeira

submission deadline 20 Sep 2026 | Viewed by 150 | Submission Open

Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology

Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases

edited by Fabio M. Macciardi

submission deadline 20 Sep 2026 | Viewed by 108 | Submission Open

Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders

(This special issue belongs to the Section Cellular Neuroscience)

Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities

edited by

Giovannino Silvestri

, Aditi Chatterjee and Maria Baer

submission deadline 25 Sep 2026 | Viewed by 492 | Submission Open

Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by