NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 1 August 2026 | Viewed by 3
Special Issue Editors
Interests: natural products
Special Issue Information
Dear Colleagues,
NF-κB is a central transcription factor regulating immune and inflammatory responses, cell survival, and tissue homeostasis. Aberrant activation of NF-κB signaling has been implicated in a wide range of acute and chronic inflammatory diseases, including cancer. Despite decades of intensive research, NF-κB remains a highly dynamic and context-dependent signaling hub, with complex regulatory mechanisms operating at multiple molecular levels. This Special Issue aims to provide a comprehensive overview of recent advances in the understanding of NF-κB signaling in inflammation, with a particular focus on molecular mechanisms, regulatory networks, and therapeutic opportunities, including its critical involvement in inflammation‑associated diseases such as autoimmune disorders, metabolic conditions, neuroinflammation, and cancer.
Topics of interest include canonical and non-canonical NF-κB pathways, upstream signaling events, post-translational modifications, crosstalk with other signaling cascades, and cell-type specific regulation in immune and non-immune cells. In addition, this Special Issue welcomes studies addressing the role of NF-κB in inflammatory pathologies and the development of pharmacological or biological strategies targeting NF-κB signaling components.
By bringing together original research articles and high-quality reviews, this Special Issue aims to highlight emerging concepts and translational perspectives, fostering a deeper understanding of NF-κB driven inflammation and supporting the development of innovative therapeutic approaches.
Dr. Gaetano Spinelli
Dr. Francesco Di Blasi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- NF-κB signaling
- inflammation
- canonical and non-canonical pathways
- immune regulation
- post-translational modifications
- signal transduction
- inflammatory diseases
- autoimmune disorders
- cancer
- tumor microenvironment
- oncogenesis
- metabolic diseases
- neuroinflammation
- therapeutic targets
- drug development
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
