Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 8
Special Issue Editors
Interests: infectious diseases; HIV; tuberculosis; cytokines; iron metabolism; Immunotherapy; metabolomics; ionomics
Interests: the regulation of mitochondrial membrane phospholipid composition; mitochondrial dynamics; mito-ER contacts; respiration; the mitochondrial stress response by phospholipid-remodeling proteins
Interests: gene therapy (of oral cancer); photodynamic therapy (of oral cancer); bacteriophage therapy (of mycobacterium infections); HIV eradication (via suicide gene therapy); nanomedicine
Special Issues, Collections and Topics in MDPI journals
Interests: inflammatory arthritis
Special Issue Information
Dear Colleagues,
Understanding how immune cells adapt, fail, or persist in the face of infection remains one of the most important challenges in immunology. Persistent infections such as HIV and tuberculosis provide unique windows into these processes, where immune dysfunction, reservoir persistence, and molecular signaling pathways interact to shape disease outcomes. Yet the underlying mechanisms at the cellular level are still incompletely understood.This Special Issue aims to highlight research that uncovers the cellular and molecular basis of immune dysfunction and persistence in infectious diseases. We welcome original research articles, reviews, and perspectives that use experimental and high-dimensional approaches, including single-cell analyses and multi-omics, to investigate immune networks at the cellular level.Topics of interest include:Cellular and molecular pathways driving immune dysfunction and pathogen persistenceMechanisms of T cell exhaustion, activation, and regulation in HIV, tuberculosis, and related infectionsMolecular and transcriptional signatures linked to disease progression, latency, or therapeutic responseComparative insights across chronic and acute infections to identify shared or distinct immune mechanismsExperimental models and innovative tools that provide new perspectives on immune persistence and dysfunctionBy integrating cellular immunology with molecular insights, this Special Issue will bring together diverse studies that advance our understanding of infection outcomes, inform biomarker discovery, and guide the development of novel therapeutic strategies.
Dr. Sandeep Rai Kaushik
Dr. Pradeep Kumar Sheokand
Prof. Dr. Nejat Düzgüneş
Dr. Ekta Saini
Dr. Prashant Bajpai
Guest Editors
Manuscript Submission Information
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Keywords
- immune cell dysfunction
- immune persistence
- T cell exhaustion
- chronic infection
- host–pathogen interactions
- cellular immunity
- molecular immune signaling
- single-cell immunology
- immune cell plasticity
- infection-induced immune remodeling
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