Kinin System in Health and Disease: Cellular and Molecular Perspectives
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 December 2025 | Viewed by 22
Special Issue Editors
Interests: kallikrein–kinin system; bradykinin receptors; inflammation; metabolic disease; tumorigenesis
Special Issue Information
Dear Colleagues,
The kallikrein-kinin system (KKS) represents a complex and versatile network of multifunctional peptides—kinins—that exert profound effects on human physiology and pathology. Kinins interact dynamically with a wide range of molecular mediators, influencing essential biological functions in the vascular system, renal regulation, and central nervous system. Their role has been implicated in a variety of acute and chronic conditions, including inflammation, pain, hypertension, renal and cardiovascular diseases, obesity, ischemic stroke, and infectious diseases, such as COVID-19.
This Special Issue aims to bring together cutting-edge research exploring the cellular and molecular mechanisms of the kallikrein-kinin system in health and disease. We welcome original research articles, reviews, and perspectives that address the KKS from diverse angles—including its regulation, cross-talk with other pathways, and therapeutic potential in disease modulation.
Topics of interest include, but are not limited to:
- Molecular signaling pathways involving bradykinin receptors (B1R, B2R)
- The role of the KKS in cardiovascular and renal physiology
- Kinins in neuroinflammation and stroke
- KKS interactions with the immune system and inflammatory cascades
- KKS involvement in metabolic disorders (e.g., obesity, diabetes)
- Therapeutic modulation of the KKS in infectious diseases, including SARS-CoV-2
- Novel biomarkers and targets within the KKS for disease prediction or intervention
- Cross-regulation between the KKS and other vasoactive or hormonal systems
We encourage submissions that explore basic mechanisms, translational approaches, highlighting the KKS as a central player in the molecular landscape of health and disease.
Dr. Marcos Gregnani
Dr. Leonardo Martins
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- kallikrein–kinin system
- bradykinin receptors
- inflammation
- cardiovascular disease
- molecular pathways
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