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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Tissue Engineering Approaches for Bone Repair and Regeneration

edited by

Elaheh Dalir Abdolahinia

submission deadline 10 Jul 2026 | Viewed by 17 | Submission Open

Keywords: bone tissue engineering; bone regeneration; biomaterials and scaffolds; bone cancer; 3D printing; bioprinting

(This special issue belongs to the Section Tissues and Organs)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 15 Jul 2026 | 3 articles | Viewed by 7899 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 15 Jul 2026 | 1 articles | Viewed by 3703 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies

edited by Sujatha Kannan and

Elizabeth Winans Tucker

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2063 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Jul 2026 | Viewed by 432 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cellular Neuroscience)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Jul 2026 | Viewed by 278 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 101 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

MET: Signaling, Regulation, and Biological Roles

edited by Abdulhameed Al-Ghabkari and William W. Lockwood

submission deadline 15 Jul 2026 | Viewed by 99 | Submission Open

Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy

(This special issue belongs to the Section Cell Signaling)

Skeletal Muscle Plasticity in Health, Aging and Disease

edited by

Junaith S. Mohamed

submission deadline 15 Jul 2026 | Submission Open

Keywords: skeletal muscle; muscle plasticity; muscle regeneration; muscle atrophy; mitochondria; autophagy; non-coding RNAs

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4805 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Applications of Nanotechnology and Molecular Imaging in Cancer

edited by

Zheng-Rong Lu

and Victoria Laney

submission deadline 20 Jul 2026 | Viewed by 21 | Submission Open

Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment

Epigenetic and Metabolic Regulation of Cancer—2nd Edition

edited by

Jung-Hyun Kim

and

Ming Tan

submission deadline 20 Jul 2026 | Viewed by 15 | Submission Open

Keywords: cancer; epigenetic; transcription; chromatin; tumor metabolism; immunometabolism

(This special issue belongs to the Section Cellular Metabolism)

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2026 | Viewed by 318 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 30 Jul 2026 | Viewed by 105 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

Mitochondria in Cancer Immune Evasion and Immunotherapy

edited by Loredana Moro and

Flora Guerra

submission deadline 30 Jul 2026 | Viewed by 69 | Submission Open

Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response

(This special issue belongs to the Section Cellular Immunology)

New Advances in Immunomodulation Using Biomaterials

edited by

Gundula Schulze-Tanzil

and Vaishali Inamdar

submission deadline 30 Jul 2026 | Viewed by 52 | Submission Open

Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Jul 2026 | Viewed by 9 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Jul 2026 | 8 articles | Viewed by 19553 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 6 articles | Viewed by 10172 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7127 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Jul 2026 | 6 articles | Viewed by 5540 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5250 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 6 articles | Viewed by 4169 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3526 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2959 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2065 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 31 Jul 2026 | Viewed by 368 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Jul 2026 | Viewed by 269 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction

edited by Namrata Anand

submission deadline 31 Jul 2026 | Viewed by 186 | Submission Open

Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction

(This special issue belongs to the Section Cellular Immunology)

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Jul 2026 | Viewed by 183 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 123 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy

Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 82 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 31 Jul 2026 | Viewed by 47 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

Molecular Mechanisms to Treatment Progress of Ovarian Cancer

edited by Amal M. El-Naggar

submission deadline 31 Jul 2026 | Viewed by 40 | Submission Open

Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research

(This special issue belongs to the Section Reproductive Cells and Development)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition

edited by Sachin Mulik, Weshely Kujur,

Engin Berber

and Sumit Sen Santara

submission deadline 31 Jul 2026 | Viewed by 38 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Sex Differences in Molecular Mechanisms Linking Neuronal Stress and Inflammation

edited by John R. Bethea and Kayla Lee Nguyen

submission deadline 31 Jul 2026 | Viewed by 35 | Submission Open

Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Histological Classification of Lung Cells Across Animal Models and Life Stages

edited by

Roberta Ciccimarra

submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open

Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing

(This special issue belongs to the Section Tissues and Organs)

Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis

edited by

Sandeep Rai Kaushik

, Pradeep Kumar Sheokand,

Nejat Düzgüneş

, Ekta Saini and Prashant Bajpai

submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open

Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling

(This special issue belongs to the Section Cellular Immunology)

Uncovering Placental Inflammatory Pathways Affecting the Developing Brain

edited by

Guillaume Sébire

and

Math Chevin

submission deadline 31 Jul 2026 | Submission Open

Keywords: neuroplacentology; neuroinflammation; hypoxia– ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture

(This special issue belongs to the Section Reproductive Cells and Development)

NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets

edited by Gaetano Spinelli and

Francesco Di Blasi

submission deadline 1 Aug 2026 | Viewed by 25 | Submission Open

Keywords: NF-κ B signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 5 Aug 2026 | Viewed by 217 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 10 Aug 2026 | 8 articles | Viewed by 21025 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 10 Aug 2026 | 1 articles | Viewed by 2725 | Submission Open

Keywords: cellular therapies; cancer; immune

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Aug 2026 | Viewed by 569 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Study on Ovarian Follicle Development

edited by Cecily V. Bishop and Jessica Cristina Lemos Motta

submission deadline 10 Aug 2026 | Viewed by 187 | Submission Open

Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Aug 2026 | 1 articles | Viewed by 3148 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation

edited by

Eugenie S. Kleinerman

and

Pradeep Shrestha

submission deadline 15 Aug 2026 | Viewed by 48 | Submission Open

Keywords: osteosarcoma; immunotherapy; biomarker

(This special issue belongs to the Section Cellular Pathology)

Autophagy-Related Proteins in Stress Responses

edited by