Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 25
Special Issue Editors
Interests: CaM kinase II; memory; intellectual disability; synaptic plasticity; neurodegeneration; amyloid beta; synuceluin; fatty acid binding protein
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuromodulatory signaling plays a critical role in regulating neural circuit dynamics, synaptic plasticity, and behavioral outcomes. Recent studies have demonstrated that disruptions in neuromodulatory signaling mechanisms are closely associated with a wide range of brain disorders, including substance addiction, affective disorders, neurodegenerative diseases, and neuroinflammatory conditions. These pathologies are commonly associated with neurotransmitter dysfunction, altered receptor signaling, and impaired neural network regulation. Therefore, a deeper understanding of neuromodulatory processes at the molecular, cellular, and circuit levels is critical for uncovering disease mechanisms and advancing the development of targeted therapeutic strategies.
This Special Issue invites high-quality contributions that advance our understanding of the neuromodulatory signaling underlying neurological disorders. Topics of interest include intracellular and extracellular signaling cascades, receptor-mediated pathways, second-messenger systems, mechanisms of synaptic plasticity, and the interactions between neuromodulatory signals, immune responses, and neuroinflammation. Studies examining how disruptions in neuromodulatory balance contribute to the development of substance use disorders and the progression of neurodegenerative or neuroinflammatory conditions, including, but not limited to, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and multiple system atrophy, are relevant to this issue.
This Special Issue focuses on mechanistic, basic, and translational research. It seeks to integrate advances in molecular and cellular neuroscience to enhance our understanding of neuromodulatory signaling and to facilitate the development of innovative therapeutic strategies.
Prof. Dr. Kohji Fukunaga
Dr. Wenbin Jia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuromodulatory signaling
- neural circuit
- synaptic plasticity
- neurotransmitter
- signal transduction
- neurodegenerative diseases
- neuroinflammatory disorder
- substance use disorder
- neurodevelopmental disorder
- targeted therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
