Role of Hippo Signaling in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 15 July 2026 | Viewed by 44
Special Issue Editors
Interests: cancer research; tumor metabolism; immunology; immunometabolism
Interests: signaling pathways; signal transduction; apoptosis; cancer biology; cell culture; PCR; inflammation; stem cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Hippo signaling pathway plays a pivotal role in regulating tissue homeostasis, organ size, and cellular proliferation through the activity of its key effectors, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif). In cancer, aberrant activation of YAP/TAZ promotes tumorigenesis by enhancing oncogenic transcriptional programs that drive proliferation, survival, epithelial-to-mesenchymal transition, and stemness. These transcriptional coactivators act in concert with transcriptional enhanced associate domain (TEAD) factors to orchestrate gene expression profiles that support malignant transformation and resistance to therapy.
TEAD inhibitors have recently emerged as a novel class of targeted therapeutics designed to disrupt the oncogenic functions of YAP and TAZ. By impairing tumor growth and pathological neovascularization, these agents position the Hippo pathway as a promising target for cancer therapy.
Beyond intrinsic tumor cell effects, the Hippo pathway also governs key aspects of the tumor microenvironment, particularly in tumor angiogenesis. YAP and TAZ are mechanosensitive regulators of endothelial cell behavior, controlling proliferation, migration, and vascular barrier integrity in response to biomechanical and biochemical cues. In the context of cancer, their activation in endothelial cells supports pathological angiogenesis, facilitating tumor vascularization, immune evasion, and metastatic dissemination.
The aim of this Special Issue is to present up-to-date results that may expand our knowledge around the multifaceted role of the Hippo pathway in cancer biology and the regulation of the tumor microenvironment.
Both research and review articles related to the current state of the art in this field are welcome.
Dr. Dimpi Mukhopadhyay
Dr. Alessio D'Alessio
Guest Editors
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Keywords
- angiogenesis
- cancer metabolism
- cancer stemness
- chemoresistance
- endothelial cell plasticity
- epithelial-to-mesenchymal transition (EMT)
- hippo signaling pathway
- immunotherapy
- mechanotransduction
- targeted cancer therapy
- TEAD transcription factors
- therapeutic resistance
- tumor microenvironment
- tumorigenesis
- YAP/TAZ
- new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis
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