Advances in Tissue Engineering Approaches for Bone Repair and Regeneration

Dear Colleagues,

Bone tissue engineering has emerged as a promising strategy for the repair and regeneration of critical-size bone defects caused by trauma, degenerative diseases, congenital abnormalities, and tumor resection. In parallel, cancer-related bone diseases—such as primary bone tumors and bone metastases—pose significant clinical challenges due to complex tumor–bone interactions, impaired healing, and high recurrence rates.

Recent advances in tissue engineering have expanded beyond conventional regenerative approaches to include cancer-related applications, such as engineered bone tumor models, biomimetic platforms for studying tumor microenvironments, and multifunctional scaffolds capable of promoting bone regeneration while delivering anti-cancer therapies. The integration of biomaterials, stem cells, growth factors, and advanced fabrication technologies (e.g., 3D printing and bioprinting) has opened new avenues for both bone repair and cancer research.

This Special Issue, “Advances in Tissue Engineering Approaches for Bone Repair and Regeneration,” aims to gather high-quality contributions addressing fundamental, translational, and clinical aspects of bone tissue engineering in both regenerative and oncological contexts.

We invite original research articles, reviews, and short communications focusing on, but not limited to, the following topics:

• Biomaterials and scaffolds for bone repair after tumor resection;
• Tissue-engineered models of bone cancer and bone metastasis;
• Tumor microenvironment and cancer–bone interactions;
• Multifunctional scaffolds for combined bone regeneration and anti-cancer therapy;
• Stem cell-based strategies in bone regeneration and cancer research;
• Three-dimensional printing and bioprinting for bone repair and tumor modeling;
• Drug delivery systems targeting bone tumors;
• In vitro and in vivo models for bone regeneration and cancer;
• Clinical translation in orthopedic oncology and regenerative medicine.

We believe that this Special Issue will serve as a valuable platform for researchers working at the interface of tissue engineering, bone biology, and cancer research.

Dr. Elaheh Dalir Abdolahinia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.