Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Mechanisms of Testosterone in Metabolic Disorders
edited by Daniel M. Kelly
submission deadline 13 Apr 2026 | Viewed by 131 | Submission Open
Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling
Modeling Developmental Processes and Disorders in Zebrafish submission deadline 15 Apr 2026 | 13 articles | Viewed by 57915 | Submission Open
(This special issue belongs to the Section Cellular Biophysics)
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 15 Apr 2026 | 5 articles | Viewed by 27278 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 15 Apr 2026 | 5 articles | Viewed by 11872 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Zebrafish Disease Models submission deadline 15 Apr 2026 | 4 articles | Viewed by 7142 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies submission deadline 15 Apr 2026 | 3 articles | Viewed by 2743 | Submission Open
Keywords: hypoxia; oxidative stress; angiogenic markers; HIF-1/VEGF axis; retinal diseases; β -adrenoceptors; electroretinographic responses
(This special issue belongs to the Section Tissues and Organs)
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Apr 2026 | 2 articles | Viewed by 2739 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression
edited by and Sudheer Kumar Gara
submission deadline 15 Apr 2026 | 1 articles | Viewed by 2436 | Submission Open
Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy
edited by , Stephanie L. Grillo and
submission deadline 15 Apr 2026 | 1 articles | Viewed by 1956 | Submission Open
Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies submission deadline 15 Apr 2026 | 1 articles | Viewed by 1726 | Submission Open
Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Translational Aspects of Cell Signaling
edited by
submission deadline 15 Apr 2026 | 2 articles | Viewed by 1006 | Submission Open
Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research
Decoding Cancer Metabolism: Recent Insights and Future Directions
edited by Parash Prasad and Snehasis R. Mishra
submission deadline 15 Apr 2026 | 1 articles | Viewed by 607 | Submission Open
Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing
Yeast Stress Responses and Cell Death Regulation submission deadline 15 Apr 2026 | Viewed by 445 | Submission Open
Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Apr 2026 | Viewed by 436 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
Cell Biology of the Eye: Development, Disorders, and Repair submission deadline 15 Apr 2026 | Viewed by 192 | Submission Open
Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics  
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update
edited by and
submission deadline 15 Apr 2026 | Viewed by 188 | Submission Open
Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets
Cellular Metabolism and Hormonal Signaling in Colorectal Cancer: Biomarkers and Therapeutic Opportunities
edited by Jibran Sualeh Muhammad
submission deadline 15 Apr 2026 | Viewed by 179 | Submission Open
Keywords: colorectal cancer; metabolic reprogramming; gut microbiome– metabolite interactions; therapy resistance; hormonal signaling
Advances in Annexin Biology
edited by , and Nunzia Novizio
submission deadline 15 Apr 2026 | Viewed by 169 | Submission Open
Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets
Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases
edited by and Emmanouil Metzakopian
submission deadline 15 Apr 2026 | Viewed by 139 | Submission Open
Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction
Cellular and Molecular Studies of the Adrenal Gland
edited by Wen-Jun Shen, and Salman Azhar
submission deadline 15 Apr 2026 | Viewed by 123 | Submission Open
Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’ s syndrome
Neurobiology of Sleep
edited by
submission deadline 15 Apr 2026 | Viewed by 97 | Submission Open
Keywords: sleep-wake regulation; neural circuits; glial biology; neurometabolism; sleep disorders; aging; neuropathology; astrocytes; GABAergic neurons
(This special issue belongs to the Section Cellular Neuroscience)
Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms submission deadline 20 Apr 2026 | 11 articles | Viewed by 35390 | Submission Open
Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular Mechanisms of Tumor Pathogenesis submission deadline 20 Apr 2026 | 9 articles | Viewed by 26659 | Submission Open
Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases
edited by Qingdong Guan
submission deadline 20 Apr 2026 | 2 articles | Viewed by 9321 | Submission Open
Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells
(This special issue belongs to the Section Cellular Immunology)
Chromosomal Instability in Health and Disease
edited by Anna V. Roschke
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7238 | Submission Open
Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Sperm Biology and Reproductive Health—Second Edition
edited by and
submission deadline 20 Apr 2026 | 2 articles | Viewed by 5628 | Submission Open
Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation
New Advances in Anticancer Therapy
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 5276 | Submission Open
Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology
(This special issue belongs to the Section Cellular Pathology)
Advancements in Research on hiPSC-Derived Cells
edited by Akhilesh Kumar
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2496 | Submission Open
Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering
(This special issue belongs to the Section Stem Cells)
Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer
edited by Giusi Alberti and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1279 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research
pH Sensing, Signalling, and Regulation in Cellular Processes 
edited by Maike Glitsch
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1259 | Submission Open
Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets
(This special issue belongs to the Section Cell Signaling)
Cell Death and Its Clearance in Health and Disease
edited by
submission deadline 20 Apr 2026 | Viewed by 446 | Submission Open
Keywords: cell death; phagocytosis; immune homeostasis; inflammation
(This special issue belongs to the Section Cellular Pathology)
Mesenchymal Stem/Stromal Cell Therapies: Innovations in Regenerative Medicine and Translational Applications
edited by Giandomenico Amico and Paolo Elia Cappella
submission deadline 20 Apr 2026 | Viewed by 341 | Submission Open
Keywords: mesenchymal stem cells (MSCs); stromal cells; microvesicles; exosomes; extracellular vesicles (EVs); immunomodulatory properties; bone marrow; adipose tissue; Wharton’ s jelly; cord blood; placenta; amnion
(This special issue belongs to the Section Stem Cells)
Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance submission deadline 20 Apr 2026 | Viewed by 188 | Submission Open
Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System
edited by Emanuela Paldino
submission deadline 20 Apr 2026 | Viewed by 172 | Submission Open
Keywords: microglia; macrophages; neurological disorders
Stress-Induced Acute Immune Activation and Its Biological Consequences
edited by Ana Cicvaric
submission deadline 20 Apr 2026 | Viewed by 151 | Submission Open
Keywords: stress-induced immune signaling; acute immune activation; innate immune cell activation; cytokine response; cellular stress responses; inflammation and homeostasis
Signalling Mechanisms Regulating Cardiac Fibroblast Function
edited by Haofei Wang and
submission deadline 20 Apr 2026 | Viewed by 135 | Submission Open
Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting
Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
edited by
submission deadline 20 Apr 2026 | Viewed by 95 | Submission Open
Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis
edited by and
submission deadline 20 Apr 2026 | Viewed by 83 | Submission Open
Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial– mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence
Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders submission deadline 20 Apr 2026 | Viewed by 73 | Submission Open
Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy
(This special issue belongs to the Section Cellular Neuroscience)
New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)
edited by
submission deadline 20 Apr 2026 | Viewed by 60 | Submission Open
Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 25 Apr 2026 | 5 articles | Viewed by 19424 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cellular Neuroscience)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 25 Apr 2026 | 2 articles | Viewed by 4142 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis
edited by Alessandra Loda and
submission deadline 25 Apr 2026 | 1 articles | Viewed by 3075 | Submission Open
Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors
Molecular and Cellular Insights into Platelet Function, 2nd Edition submission deadline 25 Apr 2026 | 3 articles | Viewed by 1076 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 25 Apr 2026 | Viewed by 655 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Stem Cells in Action: Unlocking the Potential of Next-Generation Therapies
edited by George G. Koliakos
submission deadline 25 Apr 2026 | Viewed by 130 | Submission Open
Keywords: stem cell biology; differentiation and niche interaction; secretome/extracellular vesicles; organoids and disease modeling; regenerative medicine and tissue repair; immunomodulation and antimicrobial function; cell-based therapies and  cGMP translation; scaffold and biomaterial integration
(This special issue belongs to the Section Stem Cells)
Gene Editing Using Synthetic Nucleic Acids
edited by Debmalya Bhunia
submission deadline 25 Apr 2026 | Viewed by 86 | Submission Open
Keywords: gene editing; synthetic nucleic acids; genetic diseases; targeted gene therapy; antisense binding
(This special issue belongs to the Section Cell and Gene Therapy)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 30 Apr 2026 | 21 articles | Viewed by 77884 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cellular Neuroscience)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 30 Apr 2026 | 5 articles | Viewed by 22181 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities submission deadline 30 Apr 2026 | 8 articles | Viewed by 14577 | Submission Open
Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
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