Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 1070
Special Issue Editors
Interests: colorectal cancer; inflammatory bowel disease; intestinal inflammation; intestinal epithelial barrier; microbiota; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: colorectal cancer; immunotherapy; inflammatory bowel diseases; anti-cancer drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal cancer includes all cancers arising in the digestive tract organs, such as esophageal and gastric cancers, hepatobiliary cancers, pancreatic cancers, and colorectal cancers. When combined together, gastrointestinal cancers account for more new cases and deaths per year than cancers occurring in any other system of the body, and their incidence continues to increase. Additionally, in most cases, these malignancies are diagnosed at an advanced stage, leading to a poor prognosis despite the availability of different therapeutic approaches (e.g., chemotherapy, immunotherapy, radiotherapy). Even in patients with potentially curative cancer, almost half of them will develop recurrent disease. Despite recent technological advances and major scientific efforts, the cellular and molecular pathways that underpin the pathogenesis and progression of these malignancies are still being uncovered. Better knowledge of these mechanisms can definitely improve our understanding of gastrointestinal cancer cell biology and offer opportunities for the design of new and more effective therapeutic strategies.
In this Special Issue, we invite scholars working on gastrointestinal cancer to submit original research papers or review articles dealing with novel mechanistic insights and details of the molecular signatures of oncogenic transformation and disease progression. We also encourage the submission of manuscripts that focus on translating basic molecular knowledge to new medical applications. Articles focusing on diagnostic and prognostic biomarkers, as well as novel drug targets or targeted treatments, including possible clinical trials, are also welcomed.
Dr. Federica Laudisi
Dr. Carmine Stolfi
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- colorectal cancer
- gastric cancer
- liver cancer
- pancreatic cancer
- tumor microenvironment
- cytokines
- epigenetic
- checkpoint inhibitors
- biomarkers
- immunotherapy
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