Sperm Biology and Reproductive Health—Second Edition
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 October 2025 | Viewed by 801
Special Issue Editors
Interests: SSCs differentiation; mammalian oocytes; gonadal biology
Special Issues, Collections and Topics in MDPI journals
Interests: SSCs differentiation; mammalian oocytes; somatic cell clone; innate immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
According to the World Health Organization, the global fertility rate has continued to decline over the past 50 years. About 10% to 15% of couples of childbearing ages are infertile; half of them attribute this to "male factors", and 70–90% of male infertility is due to spermatogenic disorders. Endogenous damaging factors, environmental factors, bacteria and viruses, radiotherapy and chemotherapy, etc., will hinder spermatogenesis and prevent spermatogenesis in the body. Spermatogonial stem cells can self-renew and differentiate into sperm. An ideal solution is to use seed cells (SSC) to induce differentiation in vitro to obtain sperm, and then to obtain individual samples by single sperm injection. Scientists have obtained rat functional sperm by testicular tissue culture; however, the efficiency of differentiation in vitro is low, and the differentiation system is still imperfect. The main reason is that the differentiation mechanism of SSCs is still unclear. Spermatogenesis is a complex process that undergoes mitosis, meiosis and spermiogenesis. At present, the molecular and cellular mechanisms in spermatogenesis are not completely clear. Exploring the mechanism of spermatogenesis, optimizing the round sperm injection system and finally obtaining individuals can improve the assisted reproductive system based on round sperm.
This topic will discuss the mechanism of spermatogenesis, the treatment of male infertility (non-obstructive azoospermia (NOA)), and the preservation of male fertility (pre-adolescent cancer patients who are facing infertility due to cancer treatment, patients who have received radiotherapy and chemotherapy).
Prof. Yi-Xun Liu
Dr. Shou-Long Deng
Guest Editors
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Keywords
- spermatogenesis
- differentiation of spermatogonial stem cells in vitro
- mitosis
- meiosis
- sperm formation
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Related Special Issue
- Sperm Biology and Reproductive Health in Cells (7 articles)
