Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer

Dear Colleagues,

Thanks to efforts made in recent years to uncover the factors involved in cancer progression, it is now clear that each factor has a unique imprint in cancer pathogenesis. Extracellular vesicles (EVs) and exosomes (Exos) are small structures involved in the regulation of biological processes through their cargo, which can comprise proteins, lipids, or nucleic acids. They are produced by tumor cells and function as a unique form of intercellular communication that can promote cell growth and survival, help shape the tumor microenvironment, and increase invasive and metastatic activity. However, the application of complex culture models to unravel the role of EVs and Exos in cancer research has not yet been popularized within EV research, given the difficulties that this type of culture presents, both technically and in terms of costs. This Special Issue will highlight the involvement of EVs and Exos in cancer physiology in order to identify potential applications in clinical oncology. The unique properties of EVs and Exos mean that they are promising tools in the therapeutic treatment of diseases, including neurodegenerative conditions and various types of cancer, highlighting the importance of 3D cultures in the study of EVs and Exos.

Dr. Giusi Alberti
Dr. Celeste Caruso Bavisotto
Guest Editors

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