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Cells
Special Issues
Unlocking the Secrets Behind Drug Resistance at the Cellular Level
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Unlocking the Secrets Behind Drug Resistance at the Cellular Level

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 4600

Special Issue Editors

Dr. Sara Ricardo

E-Mail Website
Guest Editor
1. UCIBIO—Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal
2. Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal
Interests: oncobiology; molecular pathology; ovarian cancer; drug resistance; drug repurposing
Dr. Cristina Pinto Ribeiro Xavier

E-Mail Website
Guest Editor
1. UCIBIO—Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), Gandra, Portugal
2. Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences—CESPU, Gandra, Portugal
3. i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
Interests: cancer resistance; pancreatic cancer; molecular biology; medical biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug resistance is becoming a growing health concern. It can be developed by simple prokaryote cells to complex eukaryote cells, such as cancer cells. The World Health Organization (WHO) has identified antimicrobial resistance as one of the three significant public health challenges of the twenty-first century. Additionally, chemoresistance associated with cancer treatments is another big challenge of this century, and it is expected to increase in the coming years.

This Special Issue will contribute to the understanding of the underlying cellular mechanisms that lead to drug resistance. This issue aims to examine the mechanisms behind antibiotic resistance that are attributed to target protein alteration, integron operon network, anthropogenic activities, horizontal gene transfer, transposons and mutation in protein genes. In addition, it will investigate the ways by which drug resistance is developed in cancer, generally linked with several factors such as apoptotic pathways, immune system dysfunction, epigenetic changes and the activation of detox systems such as ROS. Other factors that can lead to chemoresistance include drug delivery problems, increased drug efflux or reduced influx, enhanced intrinsic DNA repair mechanisms and increased drug metabolism in the liver. Understanding the mechanisms behind drug resistance can trigger the development of new strategies to improve treatment efficacy in these two different disease contexts.

Dr. Sara Ricardo
Dr. Cristina Pinto Ribeiro Xavier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular mechanisms
  • effective treatments
  • drug tests
  • bacterial resistance
  • chemoresistance

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Published Papers (2 papers)

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24 pages, 12573 KiB  
Article
Overcoming Therapy Resistance in Colorectal Cancer: Targeting the Rac1 Signaling Pathway as a Potential Therapeutic Approach
by Luciano E. Anselmino, Florencia Malizia, Aylén Avila, Nahuel Cesatti Laluce, Macarena Mamberto, Lucía C. Zanotti, Cecilia Farré, Vincent Sauzeau and Mauricio Menacho Márquez
Cells 2024, 13(21), 1776; https://doi.org/10.3390/cells13211776 - 26 Oct 2024
Viewed by 1356
Abstract
Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide and is responsible for numerous deaths. 5-fluorouracil (5-FU) is an effective chemotherapy drug commonly used in the treatment of CRC, either as monotherapy or in combination with other drugs. However, [...] Read more.
Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide and is responsible for numerous deaths. 5-fluorouracil (5-FU) is an effective chemotherapy drug commonly used in the treatment of CRC, either as monotherapy or in combination with other drugs. However, half of CRC cases are resistant to 5-FU-based therapies. To contribute to the understanding of the mechanisms underlying CRC resistance or recurrence after 5-FU-based therapies, we performed a comprehensive study integrating in silico, in vitro, and in vivo approaches. We identified differentially expressed genes and enrichment of pathways associated with recurrence after 5-FU-based therapies. Using these bioinformatics data as a starting point, we selected a group of drugs that restored 5-FU sensitivity to 5-FU resistant cells. Interestingly, treatment with the novel Rac1 inhibitor, 1A-116, reversed morphological changes associated with 5-FU resistance.. Moreover, our in vivo studies have shown that 1A-116 affected tumor growth and the development of metastasis. All our data allowed us to postulate that targeting Rac1 represents a promising avenue for the development of new treatments for patients with CRC resistant to 5-FU-based therapies. Full article
(This article belongs to the Special Issue Unlocking the Secrets Behind Drug Resistance at the Cellular Level)
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Review

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35 pages, 2892 KiB  
Review
Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options
by Mariana Nunes, Carla Bartosch, Miguel Henriques Abreu, Alan Richardson, Raquel Almeida and Sara Ricardo
Cells 2024, 13(9), 786; https://doi.org/10.3390/cells13090786 - 4 May 2024
Cited by 2 | Viewed by 2847
Abstract
Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due to the emergence of drug resistance that [...] Read more.
Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due to the emergence of drug resistance that significantly limits the effectiveness of currently available oncological treatments. Here, we discuss the molecular mechanisms responsible for resistance to carboplatin, paclitaxel, polyadenosine diphosphate ribose polymerase inhibitors, and bevacizumab in ovarian cancer. We present a detailed analysis of the most extensively investigated resistance mechanisms, including drug inactivation, drug target alterations, enhanced drug efflux pumps, increased DNA damage repair capacity, and reduced drug absorption/accumulation. The in-depth understanding of the molecular mechanisms associated with drug resistance is crucial to unveil new biomarkers capable of predicting and monitoring the kinetics during disease progression and discovering new therapeutic targets. Full article
(This article belongs to the Special Issue Unlocking the Secrets Behind Drug Resistance at the Cellular Level)
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