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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods

edited by Peter C. Angeletti

submission deadline 15 Oct 2025 | Viewed by 48 | Submission Open

Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Liquid Biopsy in Cancer 2.0

edited by

Fabio Puglisi

Lorenzo Gerratana

and

Linda Cucciniello

submission deadline 20 Oct 2025 | 9 articles | Viewed by 23133 | Submission Open

Keywords: circulating biomarkers; clinical utility; circulating tumor DNA; circulating tumor cells; exosomes; circulating RNA; precision medicine

(This special issue belongs to the Section Cancer Therapy)

What’s behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification

edited by

Emanuele Perrone

submission deadline 20 Oct 2025 | 5 articles | Viewed by 13187 | Submission Open

Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical Treatment of Osteosarcoma

edited by

Masanori Okamoto

submission deadline 20 Oct 2025 | 4 articles | Viewed by 8069 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Obesity and Cancers

edited by Edward Sauter and Tanya Agurs-Collins

submission deadline 20 Oct 2025 | 4 articles | Viewed by 7424 | Submission Open

Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

State-of-the-Art Strategies for Non-Coding RNA Function Detection and Regulation in Cancer

edited by

Antonis Giakountis

and

Nikolaos Balatsos

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7195 | Submission Open

Keywords: long non-coding RNAs; miRNAs; regulatory non-coding variants; ribodiagnostics; RNA therapeutics; targeted therapy; cancer

(This special issue belongs to the Section Tumor Microenvironment)

Advanced Research in Oncology in 2025

edited by

Dimitrios Moris

submission deadline 20 Oct 2025 | 6 articles | Viewed by 6608 | Submission Open

Keywords: cancer; tumour; oncology

Advances in Salivary Gland Carcinoma: 2nd Edition

edited by

Giulio Cantù

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3095 | Submission Open

Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Applications of Ultrasound in Cancer Imaging and Treatment

edited by Gregory Jan Czarnota

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2412 | Submission Open

Keywords: ultrasound; imaging; CT; MRI; treatment

(This special issue belongs to the Section Methods and Technologies Development)

Potential Biomarkers in Immune Checkpoint Inhibitors

edited by Goulnar Kasymjanova

submission deadline 20 Oct 2025 | Viewed by 135 | Submission Open

Keywords: advanced metastatic cancer; personalized immunotherapy; predictive biomarkers; circulating tumor DNA; resistance mechanisms; tumor microenvironment (TME); adverse events; real-world evidence

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 20 Oct 2025 | Viewed by 95 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Epigenetic Biomarkers: 2nd Edition

edited by

Fabio Coppedè

submission deadline 22 Oct 2025 | 1 articles | Viewed by 1681 | Submission Open

Keywords: cancer; biomarker; epigenetics; DNA methylation; miRNA; diagnostic biomarkers; pharmacoepigenetics; epigenetic drugs

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 23 Oct 2025 | Viewed by 308 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

New Developments in Adolescent and Young Adult Oncology

edited by

Olga Husson

and

Winette T.A. van der Graaf

submission deadline 24 Oct 2025 | 1 articles | Viewed by 2073 | Submission Open

Keywords: adolescent and young adult oncology; epidemiology; health-related quality of life; late effects; survivorship; clinical care

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2025 | 4 articles | Viewed by 9276 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

Research on Surgical Treatment for Ovarian Cancer

edited by Antonios Apostolos K. Tentes and Theo Panoskaltsis

submission deadline 25 Oct 2025 | 6 articles | Viewed by 6552 | Submission Open

Keywords: ovarian cancer; surgical; cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Prevention, Screening and Early Detection of Cancer

edited by

Nadir Arber

and

Shiran Shapira

submission deadline 25 Oct 2025 | 4 articles | Viewed by 3826 | Submission Open

Keywords: cancer prevention; screening; early detection; risk factors; lifestyle modification; biomarkers; genetic testing; lifestyle interventions; cancer risk factors; liquid biopsy; pan-cancer screening tests

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Study on Acute Myeloid Leukemia

edited by Olga K. Weinberg

submission deadline 25 Oct 2025 | 2 articles | Viewed by 1629 | Submission Open

Keywords: acute myeloid leukemia (AML); cancer treatment; genetic

(This special issue belongs to the Section Cancer Therapy)

The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies

edited by

Agnieszka Kulczyńska-Przybik

and

Sara Pączek

submission deadline 30 Oct 2025 | 3 articles | Viewed by 7041 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Radiopharmaceuticals for Cancers

edited by Joseph Lau and Hwan Lee

submission deadline 30 Oct 2025 | 2 articles | Viewed by 5414 | Submission Open

Keywords: radiopharmaceutical; positron emission tomography; single photon emission computed tomography; targeted radionuclide therapy; dosimetry; cancer; in vitro and in vivo characterization

(This special issue belongs to the Section Cancer Drug Development)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1722 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer

edited by

Mingyao Chen

and

Kuang-Chun Hu

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1641 | Submission Open

Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Treg Cell Immunotherapy in Cancer

edited by

Maria Velegraki

submission deadline 30 Oct 2025 | Viewed by 826 | Submission Open

Keywords: treg cells; cancer immunotherapy; immune evasion; antitumor immune responses; targeting therapeutic interventions

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 30 Oct 2025 | Viewed by 214 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Management of Pancreatic Cancer

edited by

Traian Dumitrascu

submission deadline 31 Oct 2025 | 19 articles | Viewed by 32329 | Submission Open

Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy

(This special issue belongs to the Section Cancer Therapy)

Neurofibromatosis

edited by Rianne Oostenbrink,

Ignaci Blanco

and Enrico Opocher

submission deadline 31 Oct 2025 | 9 articles | Viewed by 13036 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; tumor; longitudinal history; treatment; biomarker; outcomes

(This special issue belongs to the Section Cancer Therapy)

Molecular Mechanisms in Head and Neck Cancer

edited by Désirée Gül, Jan Hagemann and

Roland Hans Stauber

submission deadline 31 Oct 2025 | 6 articles | Viewed by 10677 | Submission Open

Keywords: head and neck cancer; translational research; molecular pathways; cellular signaling; biomarkers; liquid biopsies; transcriptome; proteome; survival

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Prognostic Biomarkers in Human Cancers: From Discovery to Application

edited by

Zakaria Y. Abd Elmageed

submission deadline 31 Oct 2025 | 4 articles | Viewed by 10378 | Submission Open

Keywords: tumor biomarkers; investigational markers; prognosis; biochemical relapse; overall survival; clinical trials; advancement in biomarker discovery; bioinformatics and marker discovery; AI and biomarker discovery

(This special issue belongs to the Section Cancer Biomarkers)

Treatment Outcomes in Older Adults with Cancer

edited by

Mackenzi Pergolotti

submission deadline 31 Oct 2025 | 6 articles | Viewed by 9927 | Submission Open

Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship

(This special issue belongs to the Section Cancer Therapy)

Clinical Research Advances in Endometrial Carcinoma

edited by Salvatore Lopez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9835 | Submission Open

Keywords: endometrial cancer; uterine serous carcinoma; immunotherapy; MMRd; POLE; endometrioid carcinoma; target therapies; surgery; preclinical research

(This special issue belongs to the Section Clinical Research of Cancer)

Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition)

edited by

Bartosz Małkiewicz

Jakub Dobruch

and

Łukasz Nowak

submission deadline 31 Oct 2025 | 7 articles | Viewed by 8989 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Molecular Advances in Lung Cancer: From Pathogenesis to Precision Therapy

edited by

Federico Pio Fabrizio

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8448 | Submission Open

Keywords: lung cancer molecular biology; targeted therapy; precision medicine; biomarkers; therapeutic resistance

(This special issue belongs to the Section Cancer Therapy)

Advances in TNBC: New Markers for Innovative Treatments

edited by

Pia Giovannelli

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8321 | Submission Open

Keywords: TNBC treatment; TNBC target; signaling pathways in TNBC; epigenetic modifications in TNBC; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Uveal Melanoma

edited by

Takami Sato

and

Mizue Terai

submission deadline 31 Oct 2025 | 5 articles | Viewed by 7523 | Submission Open

Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights into Targeted Drugs for Breast Cancer (Volume II)

edited by

Jennifer Diamond

and Jennifer Richer

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6805 | Submission Open

Keywords: breast cancer targeted therapies treatment resistance HER2 hormone receptor-positive triple-negative breast cancer

(This special issue belongs to the Section Cancer Drug Development)

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6779 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

A New Era in the Treatment of Early-Stage Non-Small Cell Lung Cancer

edited by

Tsutani Yasuhiro

submission deadline 31 Oct 2025 | 3 articles | Viewed by 6026 | Submission Open

Keywords: minimally invasive surgery; video-assisted thoracic surgery; robotic-assisted thoracic surgery; sublobar resection; segmentectomy; neoadjuvant therapy; adjuvant therapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Genes in Prostate Cancer

edited by Olivier Cussenot

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5979 | Submission Open

Keywords: prostate cancer; genes; microenvironment

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in “Cancer Biomarkers” for 2025–2026

edited by

Maxim V. Berezovski

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5328 | Submission Open

Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis

(This special issue belongs to the Section Cancer Biomarkers)

Neurosurgical Management of Gliomas

edited by Nicolas Reyns

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5077 | Submission Open

Keywords: neurosurgery; neurological surgery; brain surgery; gliomas

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4989 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Diagnosis and Management of Colorectal Cancer

edited by Shing Wai Wong, Stephen Thompson and Zhen Hao Ang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4072 | Submission Open

Keywords: colorectal cancer; diagnosis; management; screening; surgery; radiotherapy; chemotherapy; immunotherapy; robotics; targeted therapy; prevention; prognosis

(This special issue belongs to the Section Clinical Research of Cancer)

Neo-Adjuvant Treatment of Breast Cancer

edited by Raphael Catane

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3824 | Submission Open

Keywords: neo-adjuvant; breast cancer; chemotherapy; hormonal therapy; immunotherapy; breast cancer survival; breast cancer surgery; Norton– Simon hypothesis

(This special issue belongs to the Section Cancer Therapy)

Digital Pathology Systems Enabling the Quality of Cancer Patient Care

edited by Peter J. Schüffler

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3761 | Submission Open

Keywords: digital pathology; computational pathology; artificial intelligence; multimodal AI; foundation models; quality control; quality assurance; medical image analysis; computer-aided diagnosis; integrated digital pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Molecular Genetics, Signaling Pathways, and Therapeutic Strategies for Liver Cancer

edited by

Wai-Hung Ho Daniel

and Yuman Tsui

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3642 | Submission Open

Keywords: liver cancer; NGS; single-cell sequencing; cancer genomics; cellular and molecular landscapes; tumor microenvironment; tumor heterogeneity; liver cancer stem cell; liquid biopsy; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Research Advances in Cancer Nanomedicine

edited by

Stefano Leporatti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3287 | Submission Open

Keywords: cancer; nanotechnology; nanomedicine; drug delivery; biosensors; lab-on-chip; nanomechanics; nano-immuno therapy; CAR-T nano-technology

(This special issue belongs to the Section Methods and Technologies Development)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3121 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Roles of Deep Learning in Cancer Radiotherapy

edited by Zhen Tian

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2951 | Submission Open

Keywords: radiotherapy; deep learning; artificial Intelligence; tumor detection; image segmentation; treatment planning; outcome prediction; radiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2771 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

Diagnostic Biomarkers in Cancers Study

edited by Zejuan Li and

Xin Yi

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2560 | Submission Open

Keywords: cancer; diagnostics; biomarker

(This special issue belongs to the Section Cancer Biomarkers)

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