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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in Nanomedicine and Targeted Drugs for Breast Cancer
edited by , Gennaro Sanità, Alessandro Venuta and Rosarita Nasso
submission deadline 31 Jan 2026 | Viewed by 435 | Submission Open
Keywords: breast cancer; nanoparticles; active targeting; BC; nanomedicine
(This special issue belongs to the Section Cancer Drug Development)
The Cancer Stem Cells and the Quiescence
edited by
submission deadline 31 Jan 2026 | Viewed by 388 | Submission Open
Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis
edited by , and Thomas Gaillard
submission deadline 31 Jan 2026 | Viewed by 339 | Submission Open
Keywords: cervical cancer; lymph nodes; metastasis; isolated Tumor Cells; sentinel lymph node; non-sentinel lymph node; tumor-draining lymph nodes; microenvironment; one-step nucleic acid amplification; imaging
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)
edited by Shuji Isaji
submission deadline 31 Jan 2026 | Viewed by 239 | Submission Open
Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy
edited by
submission deadline 31 Jan 2026 | Viewed by 216 | Submission Open
Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications
edited by
submission deadline 31 Jan 2026 | Viewed by 188 | Submission Open
Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications
(This special issue belongs to the Section Molecular Cancer Biology)
Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer
edited by and
submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open
Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)
(This special issue belongs to the Section Methods and Technologies Development)
Diagnosis and Biomarkers for Hematologic Malignancies submission deadline 31 Jan 2026 | Viewed by 167 | Submission Open
Keywords: hematologic malignancies; diagnosis; biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 160 | Submission Open
Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence
(This special issue belongs to the Section Molecular Cancer Biology)
Breast Cancer and Stem Cells
edited by Leandro Marcelo Martinez
submission deadline 31 Jan 2026 | Viewed by 150 | Submission Open
Keywords: breast cancer; cancer stem cells; tumor microenvironment; metastasis; therapeutic strategies; in vitro models
(This special issue belongs to the Section Molecular Cancer Biology)
Curative Therapies for Non-Small and Small Cell Lung Cancers
edited by John Michael Varlotto
submission deadline 31 Jan 2026 | Viewed by 137 | Submission Open
Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer
(This special issue belongs to the Section Cancer Therapy)
Transformative Drug Innovations Reshaping Myeloma Treatment
edited by Despina Fotiou
submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: multiple myeloma; cellular therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications
edited by Francesco Mattioli, and Edoardo Serafini
submission deadline 31 Jan 2026 | Viewed by 127 | Submission Open
Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers
edited by
submission deadline 31 Jan 2026 | Viewed by 117 | Submission Open
Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers
(This special issue belongs to the Section Clinical Research of Cancer)
Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy
edited by
submission deadline 31 Jan 2026 | Viewed by 114 | Submission Open
Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Neoadjuvant Therapy for Urologic Cancer
edited by Marlon Perera and David Chen
submission deadline 31 Jan 2026 | Viewed by 114 | Submission Open
Keywords: urologic oncology; neoadjuvant therapy; treatment; improved survival
(This special issue belongs to the Section Cancer Therapy)
Personalized Cancer Therapy: Strategies for Overcoming On-Target and Bypass Resistance
edited by
submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open
Keywords: resistance mechanisms; biomarker; oncogene dependency; target therapy; personalized therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Thoracic Oncology Research
edited by
submission deadline 1 Feb 2026 | 1 articles | Viewed by 2846 | Submission Open
Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Therapy for HER2 Breast Cancer
edited by and Sandra M. Swain
submission deadline 1 Feb 2026 | Viewed by 129 | Submission Open
Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan
(This special issue belongs to the Section Cancer Therapy)
Cancer Immunotherapy in Clinical and Translational Research
edited by Sofia Genta
submission deadline 10 Feb 2026 | 7 articles | Viewed by 28043 | Submission Open
Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Insights into Prostate Cancer Radiotherapy
edited by
submission deadline 10 Feb 2026 | 6 articles | Viewed by 14288 | Submission Open
Keywords: prostate cancer; radiotherapy; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
New Insights into Cancer Radiotherapy submission deadline 10 Feb 2026 | 2 articles | Viewed by 2362 | Submission Open
Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Developments in the Field of Radiotherapy Treatment for Lung Cancer
edited by Ioannis C. Maroulis
submission deadline 10 Feb 2026 | 1 articles | Viewed by 1652 | Submission Open
Keywords: lung cancer; radiotherapy; non-small-cell lung cancer (NSCLC)
(This special issue belongs to the Section Cancer Therapy)
Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies
edited by
submission deadline 10 Feb 2026 | 1 articles | Viewed by 771 | Submission Open
Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Surgical Treatment of Gynecological Cancers
edited by , Joanna P. Kacperczyk-Bartnik and
submission deadline 14 Feb 2026 | 2 articles | Viewed by 2677 | Submission Open
Keywords: gynecological oncology; image-guided surgery; lymphadenectomy; minimally invasive surgery; ovarian cancer surgery; patient outcomes; perioperative care; precision surgery; radical hysterectomy; robotic-assisted surgery; surgical oncology
(This special issue belongs to the Section Cancer Therapy)
Metronomic Chemotherapy in Female Cancers
edited by
submission deadline 14 Feb 2026 | 1 articles | Viewed by 1764 | Submission Open
Keywords: metronomic chemotherapy; female cancers; anti-tumor mechanisms; clinical trials and outcomes; combination therapies
(This special issue belongs to the Section Cancer Therapy)
New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer
edited by Kelsie L. Thu
submission deadline 15 Feb 2026 | 5 articles | Viewed by 16829 | Submission Open
Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
New Strategies in Diagnosis and Treatments for Brain Tumors: 2nd Edition
edited by Sven Rainer Kantelhardt
submission deadline 15 Feb 2026 | 4 articles | Viewed by 15940 | Submission Open
Keywords: glioma; brain tumor; molecular guided therapy; personal medicine; radiomics; digital analysis; artificial intelligence; intraoperative imaging; surgical resection
(This special issue belongs to the Section Cancer Therapy)
Advances in Esophageal Cancer
edited by Sacheen Kumar
submission deadline 15 Feb 2026 | 4 articles | Viewed by 7330 | Submission Open
Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response
(This special issue belongs to the Section Cancer Therapy)
Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions submission deadline 15 Feb 2026 | 1 articles | Viewed by 2486 | Submission Open
Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence submission deadline 15 Feb 2026 | 1 articles | Viewed by 2195 | Submission Open
Keywords: oligometastases; oligo-recurrence; sync-oligometastases
(This special issue belongs to the Section Cancer Metastasis)
The Elderly Multiple Myeloma Patient in the Era of Quad Therapy and CAR-T Cells
edited by James J. Ignatz-Hoover and Koen Van Besien
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1640 | Submission Open
Keywords: multiple myeloma; quad therapy; CAR-T; elderly
(This special issue belongs to the Section Cancer Therapy)
Advances in Precision Medicine: Targeting Known and Emerging Oncogenic Targets in Lung Cancer (2nd Edition)
edited by
submission deadline 15 Feb 2026 | Viewed by 196 | Submission Open
Keywords: precision oncology; lung cancer; oncogenic target; targeted therapy; biomarker; diagnosis
(This special issue belongs to the Section Molecular Cancer Biology)
Epigenetics and Non-Coding RNAs in Multiple Myeloma
edited by
submission deadline 15 Feb 2026 | Viewed by 140 | Submission Open
Keywords: multiple myeloma; epigenetics; non-coding RNAs; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); circular RNAs (circRNAs); DNA methylation; histone modifications; drug resistance; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
Genetic Changes in CNS Neoplasms
edited by Kimberly Bojanowski Hoang
submission deadline 15 Feb 2026 | Viewed by 97 | Submission Open
Keywords: primary brain tumor; secondary brain tumor; metastasis; glioma; genetics; genomics; CNS; neoplasms
(This special issue belongs to the Section Cancer Biomarkers)
Prognostic and Predictive Biomarkers in Ovarian Cancer
edited by Jayakumar Nair
submission deadline 15 Feb 2026 | Viewed by 33 | Submission Open
Keywords: molecular biomarkers; clinical biomarkers; immune biomarkers; genetic biomarkers; ovarian cancer; personalized medicine
(This special issue belongs to the Section Cancer Biomarkers)
Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)
edited by and Min Gi
submission deadline 18 Feb 2026 | 2 articles | Viewed by 9942 | Submission Open
Keywords: cancer; screening; diagnosis; anti-cancer; drugs; mechanisms of carcinogenesis; chemopreventive agents
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Cancers
edited by and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 11010 | Submission Open
Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins
(This special issue belongs to the Section Tumor Microenvironment)
Gaps in Cancer Cachexia Research
edited by Jose M. Garcia and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 10980 | Submission Open
Keywords: cancer cachexia; physical function; innovative models; rehabilitation; patient-reported outcomes; gender; aging; skeletal muscle; brain; adipose tissue
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Quality of Life and Side Effects Management in Cancer Treatment (3rd Edition)
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 8790 | Submission Open
Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Chronic Intestinal Inflammation and Cancers (2nd Edition)
edited by Livia Biancone and David Laharie
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5461 | Submission Open
Keywords: colorectal cancer; chronic inflammation; inflammatory bowel disease; inflammation-associated dysplasia; outcomes; cancer molecular pathways
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Ultrasonography for Pancreatobiliary Cancer
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5246 | Submission Open
Keywords: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management: 2nd Edition submission deadline 20 Feb 2026 | 1 articles | Viewed by 3249 | Submission Open
Keywords: multiple myeloma (MM); hematologic malignancies; next-generation sequencing; heterogeneous disease; tumor heterogeneity; genomic landscape; outcomes; novel treatments; clinical trial
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer Biomarkers and Clinical Translation: 2nd Edition
edited by and Carmine De Angelis
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2155 | Submission Open
Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy
(This special issue belongs to the Section Cancer Biomarkers)
Advanced Surgical Modalities in Breast Cancer Treatment
edited by Jan Žatecký
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1276 | Submission Open
Keywords: breast cancer surgery; breast cancer localization; breast conserving surgery; mastectomy; oncoplastic surgery; axillary lymph node staging; sentinel lymph node biopsy; targeted axillary dissection
(This special issue belongs to the Section Clinical Research of Cancer)
Fibroblasts as Playmakers of Cancer Progression: Current Knowledge and Future Perspectives (2nd Edition)
edited by
submission deadline 20 Feb 2026 | Viewed by 271 | Submission Open
Keywords: tumor microenvironment; reactive stroma; fibroblasts; cancer progression; heterotypic interactions between cancer cells and fibroblasts; reactive stroma-targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
AI-Driven Predictive Modeling in Radiation Therapy: Toward Precision and Personalized Clinical Applications
edited by
submission deadline 20 Feb 2026 | Viewed by 249 | Submission Open
Keywords: AI-based radiotherapy; predictive modeling in oncology; personalized radiation therapy; radiomics and dosiomics; adaptive radiotherapy; treatment outcome prediction; explainable AI in medicine; multimodal data integration; clinical decision support systems; precision cancer treatment
Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy: 2nd Edition
edited by
submission deadline 20 Feb 2026 | Viewed by 207 | Submission Open
Keywords: targeted therapy; drug repositioning; biomarkers; basket trials; precision oncology; personalized medicine
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer and Aging: Challenges in Geriatric Cancer Survivorship
edited by and Dana E. Giza
submission deadline 20 Feb 2026 | Viewed by 79 | Submission Open
Keywords: geriatric oncology; survivorship; advance care planning; quality of life; de-escalation of treatment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Minimal Residual Disease in Solid Tumors: Emerging Technologies and Clinical Applications
edited by , and Aristeidis Boukouris
submission deadline 25 Feb 2026 | Viewed by 200 | Submission Open
Keywords: minimal residual disease (MRD); solid tumors; circulating tumor DNA (ctDNA); liquid biopsy; tumor-informed assays; precision oncology
(This special issue belongs to the Section Cancer Biomarkers)
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