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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Features and Immunotherapeutic Strategies in Lung Cancer
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1167 | Submission Open
Keywords: lung cancer; immunotherapy; predictive biomarkers; liquid biopsy; therapeutic resistance
Circulating Tumor DNA and Liquid Biopsy
edited by Atocha Romero
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1125 | Submission Open
Keywords: ctDNA; MRD; fragmentomics; extracellular vesicles (EVs); cell-free RNA (cfRNA); cell-free DNA (cfDNA); and microRNA (miRNA)
(This special issue belongs to the Section Tumor Microenvironment)
Means of Improving Gastric Cancer Response to Chemotherapy and Immunotherapy
edited by and
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1122 | Submission Open
Keywords: gastric cancer; chemotherapy response; immunotherapy; treatment adherence; adverse event management; oncology pharmacy; pharmacist intervention; oral anticancer agents; medication safety
Minimally Invasive and Innovative Approaches in Breast Cancer Surgery: Techniques and Outcomes submission deadline 31 Jul 2026 | 2 articles | Viewed by 1076 | Submission Open
Keywords: minimally invasive breast surgery; endoscopic mastectomy; robotic mastectomy; targeted axillary dissection; breast-conserving surgery; breast reconstruction; cryoablation; surgical outcomes; patient-reported outcomes; quality of life
(This special issue belongs to the Section Clinical Research of Cancer)
Innovations in Colorectal Cancer
edited by Sandy Hwang Fang
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1029 | Submission Open
Keywords: colon cancer; rectal cancer; innovation; clinical trials; total neoadjuvant therapy; medical oncology; radiation oncology
The Molecular Biology of Cholangiocarcinoma
edited by and Padma-Sheela Jayaraman
submission deadline 31 Jul 2026 | 1 articles | Viewed by 970 | Submission Open
Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Neuroscience
edited by Rafael Roesler
submission deadline 31 Jul 2026 | 1 articles | Viewed by 951 | Submission Open
Keywords: brain tumor; glioma; medulloblastoma; glioma-neuron crosstalk; cancer-neuron interaction; neuro-tumoral synapse; neurotransmitter signaling in cancer; tumor innervation; tumor microenvironment; chemobrain
Glioma: From Pathology to Clinical Management
edited by Xuejun Li
submission deadline 31 Jul 2026 | 1 articles | Viewed by 898 | Submission Open
Keywords: glioma heterogeneity; AI-driven imaging and machine learning; molecular pathology and epigenetics; precision neurosurgery; tumor microenvironment and immunotherapy
Clinical and Translational Research of Prostate Cancer
edited by Nathan Lawrentschuk
submission deadline 31 Jul 2026 | 1 articles | Viewed by 865 | Submission Open
Keywords: prostate cancer; translational research; clinical pathways; precision medicine; screening and diagnosis; real-world evidence; health policy; diagnostics
Multimodal Management of Hepatobiliary Cancers: Development of Surgical and Locoregional Strategies
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 792 | Submission Open
Keywords: hepatocarcinoma; liver metastasis; ultrasound guided liver resection; tumoral ablative tehniques; biliary cancers
Radiomics and Artificial Intelligence in Tumor and Normal Organ Imaging
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 759 | Submission Open
Keywords: radiomics; artificial intelligence; tumor imaging; normal organ imaging; quantitative imaging biomarkers; precision oncology; treatment response assessment
(This special issue belongs to the Section Methods and Technologies Development)
CRISPR in Cancer Biology and Therapy: 2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 687 | Submission Open
Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus
(This special issue belongs to the Section Methods and Technologies Development)
Current Progress in the Clinical Management and Basic Science of Head and Neck Cancer: 2nd Edition
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 613 | Submission Open
Keywords: head and neck cancer; immunotherapy; chemoradiotherapy; surgery; molecular biology; oncogenesis; cancer immunology
Advances in Minimally Invasive Surgery in Thoracic Oncology submission deadline 31 Jul 2026 | 1 articles | Viewed by 575 | Submission Open
Keywords: thoracic oncology; minimally invasive surgery; VATS; robotic-assisted thoracic surgery; lung cancer; segmentectomy; enhanced recovery
(This special issue belongs to the Section Clinical Research of Cancer)
Melanoma: Pathology and Translational Research—2nd Edition
edited by , and Jose A. Plaza
submission deadline 31 Jul 2026 | Viewed by 524 | Submission Open
Keywords: melanoma; histopathology; dermatopathology; molecular profiling; biomarkers; digital pathology; translational studies; cancer therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)
edited by Shuji Isaji
submission deadline 31 Jul 2026 | Viewed by 488 | Submission Open
Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms of Resistance to Cancer Therapies submission deadline 31 Jul 2026 | Viewed by 480 | Submission Open
Keywords: therapy resistance; cancer heterogeneity; drug resistance mechanisms; targeted therapy resistance; immunotherapy resistance; tumor microenvironment; epigenetic reprogramming; biomarkers of resistance; clonal evolution
(This special issue belongs to the Section Molecular Cancer Biology)
Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies
edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and
submission deadline 31 Jul 2026 | Viewed by 474 | Submission Open
Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 31 Jul 2026 | Viewed by 397 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 31 Jul 2026 | Viewed by 383 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Advances in Acute Lymphoblastic Leukemia Treatment
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 365 | Submission Open
Keywords: acute lymphoblastic leukemia; biology; clinical trial; treatment; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics
edited by Lingbin Meng
submission deadline 31 Jul 2026 | Viewed by 362 | Submission Open
Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence in Radiation Therapy for Head and Neck Cancers: Prediction, Personalization, and Precision
edited by Meysam Tavakoli
submission deadline 31 Jul 2026 | Viewed by 350 | Submission Open
Keywords: head and neck cancer; radiation therapy; artificial intelligence  ; machine learning  ; deep learning  ; toxicity prediction  ; radiomics  ; dosiomics  ; outcome modeling  ; personalized radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Perioperative and Adjuvant Immunotherapy in Lung Cancer: New Strategies, Biomarkers, Patient Selection and Toxicity Management
edited by , and Juan Carlos Trujillo-Reyes
submission deadline 31 Jul 2026 | Viewed by 350 | Submission Open
Keywords: non-small-cell lung cancer (NSCLC); immunotherapy; neoadjuvant treatment; adjuvant treatment; perioperatory treatment; chemotherapy; surgery; radiotherapy; toxicity; biomarkers
Recent Developments on PET-CT in Multiple Myeloma
edited by Carmelo Caldarella
submission deadline 31 Jul 2026 | Viewed by 341 | Submission Open
Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Computational Analysis of Cancer Clonal Evolution: Signatures, Determinants and Dynamics
edited by
submission deadline 31 Jul 2026 | Viewed by 327 | Submission Open
Keywords: clonal evolution in cancers; computational analysis; genetic determinants; epigenetic reprogramming; DNA methylation signatures; mutational signatures; tumor– immune microenvironment; cancer driver genes; somatic mutations; germline variants; multi-omics integration
(This special issue belongs to the Section Cancer Informatics and Big Data)
Multi-Omics Approaches to Tumor Antigen Discovery and Immunotherapy Target Identification
edited by and Parvin Zamani
submission deadline 31 Jul 2026 | Viewed by 327 | Submission Open
Keywords: tumor antigen discovery; multi-omics integration; cancer immunotherapy; spatial transcriptomics; tumor microenvironment; translational immunology
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeted Therapy and Emerging Biomarkers for Hepatocellular Carcinoma
edited by , , and Yizhi Ge
submission deadline 31 Jul 2026 | Viewed by 325 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; anti-tumor drug discovery and testing; liver cancer biomarker discovery; early diagnosis; immunotherapy and chemotherapy; targeted therapy; precision oncology; molecular pathways
Mitochondrial Metabolism and Cancer submission deadline 31 Jul 2026 | Viewed by 323 | Submission Open
Keywords: mitochondria; mitochondrial metabolism; cancer; bioenergetics; metabolomics; proteomics; mitochondrial dynamics; therapeutic targets; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications
edited by Francesco Mattioli, and Edoardo Serafini
submission deadline 31 Jul 2026 | Viewed by 321 | Submission Open
Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Curative Therapies for Non-Small and Small Cell Lung Cancers
edited by John Michael Varlotto
submission deadline 31 Jul 2026 | Viewed by 320 | Submission Open
Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment (2nd Edition)
edited by
submission deadline 31 Jul 2026 | Viewed by 314 | Submission Open
Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care
(This special issue belongs to the Section Clinical Research of Cancer)
Epigenetics: A New Approach to Cancer Therapy
edited by
submission deadline 31 Jul 2026 | Viewed by 313 | Submission Open
Keywords: epigenetics; targets; cancer; tumor; signaling regulation; inhibitors; drugs
(This special issue belongs to the Section Cancer Therapy)
Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy
edited by
submission deadline 31 Jul 2026 | Viewed by 311 | Submission Open
Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody– drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment in Cancer Progression and Therapy Resistance
edited by Hongxia Wang, Zhihuang Hu and Zhonghua Tao
submission deadline 31 Jul 2026 | Viewed by 307 | Submission Open
Keywords: cancer metabolism; tumor immune microenvironment; metabolic reprogramming; immunometabolism; metabolic checkpoints
(This special issue belongs to the Section Tumor Microenvironment)
Multiple Myeloma and Immunology: From Pathophysiology to Therapy
edited by Marco Rossi
submission deadline 31 Jul 2026 | Viewed by 298 | Submission Open
Keywords: multiple myeloma microenvironment; immunotherapy; T cell redirecting agents; CAR-T in multiple myeloma
(This special issue belongs to the Section Tumor Microenvironment)
Microsatellite Instability in Colorectal Cancer
edited by and Vicente Alonso-Orduña
submission deadline 31 Jul 2026 | Viewed by 274 | Submission Open
Keywords: microsatellite instability; colorectal cancer; immune checkpoint inhibitors; immune signatures
(This special issue belongs to the Section Tumor Microenvironment)
Hematopoietic Stem Cells and Cancer Immunotherapy
edited by Harinad B. Maganti
submission deadline 31 Jul 2026 | Viewed by 271 | Submission Open
Keywords: hematopoietic stem cell; transplantation; leukemia; cell biology; CAR-T cell therapies; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
The Role of Peptidases in Cancer submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open
Keywords: signaling proteases; proteolytic pathways; proteases and tumor microenvironment; protease diagnostic and therapeutic modalities in cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Advanced Immunotherapeutic Strategies and Clinical Developments in Hepatocellular Carcinoma and Gastrointestinal Cancers
edited by Kaushik Banerjee, Shayanki Lahiri and Lei Yang
submission deadline 31 Jul 2026 | Viewed by 262 | Submission Open
Keywords: hepatocellular carcinoma; gastrointestinal cancers; clinical immunotherapy; immune checkpoint inhibitors; tumor immune microenvironment; biomarkers and precision oncology; immunotherapy resistance; immune-related adverse events; combination therapy; CAR-T and adoptive cell therapy; cancer vaccines; translational and clinical research; clinical trials; real-world evidence
Tumorigenesis and Tumor Microenvironment—Insights and Interventions (TTMII) submission deadline 31 Jul 2026 | Viewed by 261 | Submission Open
Keywords: tumorigenesis; tumor microenvironment; intervention; stress biology; aging; mortalin; CARF; ashwagandha; propolis; curcumin; natural compounds
(This special issue belongs to the Section Tumor Microenvironment)
Environmental Toxicology and Cancer: Mechanisms, Risk Assessment and Therapeutic Implications
edited by
submission deadline 31 Jul 2026 | Viewed by 254 | Submission Open
Keywords: environmental carcinogenesis; toxicogenomics; particulate matter (PM2.5); aryl hydrocarbon receptor signaling; oxidative stress and DNA damage; clonal hematopoiesis of indeterminate potential; epigenetic reprogramming; endocrine disruptors; air pollution; lung cancer; hematological malignancies
Palliative and Precision Medicine Treatment for Biliary Tract Cancers (BTCs)
edited by
submission deadline 31 Jul 2026 | Viewed by 250 | Submission Open
Keywords: biliary tract cancers; precision medicine; palliative care; targeted therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Biomarkers in Liquid Biopsy: Circulating Tumor DNA (ctDNA), Circulating Tumor Cells (CTCs) and Exosomes
edited by George Zarkavelis
submission deadline 31 Jul 2026 | Viewed by 244 | Submission Open
Keywords: liquid biopsy; circulating tumor DNA; circulating tumor cells; early cancer detection; assessment of minimal residual disease (MRD); monitoring treatment response; identifying resistance to therapy
(This special issue belongs to the Section Methods and Technologies Development)
Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 244 | Submission Open
Keywords: perioperative care; cancer anesthesia; analgesia; pain management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Integrative Imaging–Genomic Modeling and AI for Precision Oncology
edited by
submission deadline 31 Jul 2026 | Viewed by 236 | Submission Open
Keywords: imaging– genomic modeling; precision oncology; machine learning; cancer imaging; digital pathology; radiogenomics; biomarker discovery; multimodal data integration
(This special issue belongs to the Section Methods and Technologies Development)
Radiation Exposure and Cancer
edited by
submission deadline 31 Jul 2026 | Viewed by 236 | Submission Open
Keywords: radiation; cancer; epidemiology; clinical research; molecular biology; exposomics
The Immune Landscape of Prostate Cancer: From Mechanisms to Therapy
edited by and Tongyu Tong
submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open
Keywords: tumor immune microenvironment; immunotherapy; immune evasion; biomarkers; translational research
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Pheochromocytoma and Paraganglioma: Molecular Insights and Clinical Frontiers
edited by
submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open
Keywords: pheochromocytoma and paraganglioma; hereditary cancer syndromes; genetic mutations; genotype– phenotype correlations; functional imaging; molecular diagnostics; biomarkers; precision oncology; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Advances and Emerging Directions in Lung Cancer Radiotherapy
edited by Arturo Navarro-Martín
submission deadline 31 Jul 2026 | Viewed by 215 | Submission Open
Keywords: lung cancer; hypofractionated radiotherapy; lattice; flash therapy; protons
(This special issue belongs to the Section Cancer Therapy)
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