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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ibrutinib in Chronic Lymphocytic Leukemia

edited by

Stefania Fiorcari

submission deadline 25 Jul 2025 | 1 articles | Viewed by 3426 | Submission Open

Keywords: BTK inhibitors; ibrutinib; chronic lymphocytic leukemia; targeted therapy; BTK; tumor microenvironment; drug combination; immunomodulation; drug resisitance

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition

edited by

Takefumi Kimura

submission deadline 25 Jul 2025 | 1 articles | Viewed by 448 | Submission Open

Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence

(This special issue belongs to the Section Cancer Therapy)

Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer

edited by

Felipe A. Calvo

submission deadline 25 Jul 2025 | Viewed by 221 | Submission Open

Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost

(This special issue belongs to the Section Cancer Therapy)

Liver Resection and Liver Transplantation for Hepatocellular Carcinoma

edited by Satoshi Ogiso

submission deadline 25 Jul 2025 | Viewed by 158 | Submission Open

Keywords: hepatocellular carcinoma; liver transplantation; liver resection

(This special issue belongs to the Section Transplant Oncology)

New Approaches to Biology and Treatment of Acute Leukemia

edited by Régis Thierry Costello and

Laure Farnault

submission deadline 30 Jul 2025 | 8 articles | Viewed by 16123 | Submission Open

Keywords: acute leukemia; targeted therapy; single-cell analysis; theranostic; high-throughput molecular biology

(This special issue belongs to the Section Cancer Therapy)

Updates in Chronic Lymphocytic Leukemia: 10 Years of Paradigm Change and Outlook for the Future

edited by Alan Skarbnik

submission deadline 30 Jul 2025 | 6 articles | Viewed by 9535 | Submission Open

Keywords: chronic lymphocytic leukemia; treatment; targeted therapy; chemotherapy; treatment resistance; quality of life

(This special issue belongs to the Section Cancer Therapy)

Cancer Cells Fostered Microenvironment in Metastasis

edited by Lin Ye

submission deadline 30 Jul 2025 | 4 articles | Viewed by 8804 | Submission Open

Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy

(This special issue belongs to the Section Cancer Metastasis)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jul 2025 | 5 articles | Viewed by 7034 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

The Genetic Analysis and Clinical Therapy in Lung Cancer

edited by

Francesca Colombo

and Frullanti Elisa

submission deadline 30 Jul 2025 | 4 articles | Viewed by 6530 | Submission Open

Keywords: lung cancer; biomarkers; genetic variants; innovative technologies; targeted therapy; immunotherapy; personalized therapy; survival; liquid biopsy pharmacogenomics

(This special issue belongs to the Section Cancer Therapy)

Genetic Analysis and Clinical Therapy in Head and Neck Cancers

edited by Alfonso Scarpa

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2227 | Submission Open

Keywords: head and neck cancers; genetic analysis; clinical therapy; personalized treatment; molecular mechanisms; cancer biology

(This special issue belongs to the Section Cancer Therapy)

Biomarkers for Gynecological Cancers

edited by

Apriliana Kartikasari

submission deadline 30 Jul 2025 | 2 articles | Viewed by 1880 | Submission Open

Keywords: biomarkers; cervical; ovarian; uterine; endometrial; vaginal; vulvar; fallopian tube

(This special issue belongs to the Section Cancer Biomarkers)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 30 Jul 2025 | 2 articles | Viewed by 1574 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1270 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

State of the Art and Novelties in Multidisciplinary Approach to Soft Tissue and Bone Sarcomas

edited by Ron Batash, Alberto Crimì, Moshe Schaffer and

Pietro Ruggieri

submission deadline 30 Jul 2025 | 1 articles | Viewed by 997 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; treatment; diagnosis; radiation therapy; chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Emerging Paradigms for Cancer Therapy: Promises and Challenges

edited by

Kyaw Thein

and Kyaw Lwin Aung

submission deadline 30 Jul 2025 | Viewed by 738 | Submission Open

Keywords: precision oncology; intratumor heterogeneity and resistance; immunotherapy; antibody– drug conjugate; drug resistance; tumor microenvironment; DNA damage response; CAR-T cell therapy in solid tumors; siRNA and peptide therapeutics

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in Proton Therapy of Head and Neck Cancer

edited by

Nancy Lee

and Irini Youssef

submission deadline 30 Jul 2025 | Viewed by 355 | Submission Open

Keywords: head and neck; intensity-modulated proton radiation; particle therapy; toxicity; outcomes

(This special issue belongs to the Section Cancer Therapy)

Insights into Lymphoma Treatment

edited by Irit Avivi

submission deadline 30 Jul 2025 | Viewed by 240 | Submission Open

Keywords: treatment; non hodgkin lymphoma; diffuse large cell lymphoma; follicular lymphoma; mantle cell lymphoma; CAR-T cell therapy; bispecific antibodies; BTK-inhibitors; BCL-2 inhibitors

(This special issue belongs to the Section Cancer Therapy)

Updates on Gene Expression Analyses in Anti-Cancer Drug Research

edited by

Ana Luísa De Sousa-Coelho

and Mónica Fernandes

submission deadline 30 Jul 2025 | Viewed by 214 | Submission Open

Keywords: gene expression profiling; anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding RNAs; multi-omics data

(This special issue belongs to the Section Cancer Drug Development)

Precision Medicine and Targeted Therapies in Neuroblastoma

edited by

Nilay Shah

submission deadline 30 Jul 2025 | Viewed by 111 | Submission Open

Keywords: pediatric oncology; solid tumors; targeted therapies; biomarkers of response; novel combination therapies; tumor microenvironment; integrative diagnostics; theranostics; telomere maintenance mechanisms; neuroblastoma

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular Mechanisms of Cancer Development and Metastasis

edited by

Babak Behnam

and Hassan Fazilaty

submission deadline 31 Jul 2025 | 9 articles | Viewed by 22091 | Submission Open

Keywords: cancer microenvironment; metastatic pathway; cancer stem cell; Epithelial-to-mesenchymal transition; EMT; Cell invasion; Immune evasion; Cell plasticity; Cell migration

(This special issue belongs to the Section Cancer Metastasis)

Targeted Therapies for Cancer Metastasis

edited by

Katrien Remaut

and

Wim P. Ceelen

submission deadline 31 Jul 2025 | 5 articles | Viewed by 17871 | Submission Open

Keywords: nucleic acids in cancer treatment (siRNA; mRNA; pDNA; … ); antibodies in cancer treatment; immunotherapy; cancer vaccines; cancer gene therapy; cell based therapy; tumor environment responsive materials; controlled release formulations; locoregional triggered drug delivery; delivery barriers to targeted cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Skin Cancer: Risk Factors and Prevention

edited by Feras M. Ghazawi,

Ivan V. Litvinov

and

Robert Gniadecki

submission deadline 31 Jul 2025 | 6 articles | Viewed by 10118 | Submission Open

Keywords: skin cancer; dermatology; risk factors; prevention; screening; early detection; epidemiology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Genitourinary Malignancies

edited by

Dominick Bosse

submission deadline 31 Jul 2025 | 5 articles | Viewed by 9889 | Submission Open

Keywords: genitourinary malignancy; renal cell carcinoma; prostate cancer; urothelial cancer; germ cell tumor; outcomes; toxicities; quality of life; markers; treatment sequencing

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer Therapy: Supporting Strategies and Management Options

edited by

Ingmar Wolff

and

Matthias May

submission deadline 31 Jul 2025 | 4 articles | Viewed by 8073 | Submission Open

Keywords: prostate cancer; therapy; supporting strategies; management options; lifestyle modifications; dietary interventions; risk reduction techniques; prehabilitation; physical activity; interdisciplinary approach; cancer early detection strategies; rehabilitation; complications

(This special issue belongs to the Section Cancer Therapy)

Stereotactic Radiotherapy in Tumor Ablation (Volume II)

edited by

Rémy Kinj

and

Jean Bourhis

submission deadline 31 Jul 2025 | 6 articles | Viewed by 7430 | Submission Open

Keywords: SBRT; stereotactic body radiotherapy; SABR; stereotactic ablative radiotherapy; re-irradiation; oligometastasis; local therapy

(This special issue belongs to the Section Cancer Therapy)

Cancer and Immunomediated Inflammatory Diseases (IMIDs)

edited by

Sandro Ardizzone

submission deadline 31 Jul 2025 | 3 articles | Viewed by 6524 | Submission Open

Keywords: cancer risk; IMIDs; autoinflammatory diseases; autoimmune diseases; immune-mediated inflammatory diseases; immune-regulatory mechanism; carcinogenesis

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Extracellular Matrix Proteins in Cancer

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 31 Jul 2025 | 4 articles | Viewed by 4925 | Submission Open

Keywords: extracellular matrix; cancer; tumor microenvironment; ECM proteins; proteoglycans; glycoproteins; collagens; fibrous proteins; molecular mechanisms

(This special issue belongs to the Section Tumor Microenvironment)

Novel Targeted Therapies in Brain Tumors

edited by

Maria Caffo

Emanuela Esposito

and

Paola Gaviani

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4902 | Submission Open

Keywords: precision-medicine; targeted-therapy; brain tumors; immunotherapy; glioma; meningioma

(This special issue belongs to the Section Cancer Therapy)

Multimodal Treatment for Pancreatic Cancer

edited by

Cosimo Sperti

submission deadline 31 Jul 2025 | 5 articles | Viewed by 4425 | Submission Open

Keywords: pancreatic cancer; multimodal therapy; neoadjuvant therapy; surgery of pancreatic cancer; surgical complications; response to therapy; survival; recurrence; loco-regional therapy; novel therapies

(This special issue belongs to the Section Cancer Therapy)

Exploiting Liabilities in Mechanism of DNA Repair for Cancer Therapy

edited by

Arrigo De Benedetti

, Mariarita de Felice and Mariarosaria de Falco

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3287 | Submission Open

Keywords: mechanisms of DNA repair; DDR; targeted radio- and chemotherapies; mechanisms of genotoxins tolerance/resistance; synthetic lethality

(This special issue belongs to the Section Molecular Cancer Biology)

Medical Complications and Supportive Care in Patients with Cancer (2nd Edition)

edited by

Javier Marco-Hernández

submission deadline 31 Jul 2025 | 3 articles | Viewed by 3198 | Submission Open

Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Current Concept and Management of Pediatric ATRTs

edited by

Tadanori Tomita

and Alicia C. Lenzen

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3110 | Submission Open

(This special issue belongs to the Section Pediatric Oncology)

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Cancer Therapy

edited by Andrea Di Giorgio

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2566 | Submission Open

Keywords: PIPAC; intraperitoneal chemotherapy; aerosol chemotherapy; peritoneal metastasis; neoadjuvant; bidirectional treatment; patient selection; peritoneal carcinomatosis

(This special issue belongs to the Section Cancer Therapy)

Emerging Research on Primary Brain Tumors

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2350 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1706 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Evolving Understanding of the Epidemiology of Thyroid Cancer

edited by

Marco Capezzone

and

Anello Marcello Poma

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1682 | Submission Open

Keywords: thyroid cancer; epidemiology; incidence; time trends; mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention

edited by Adam Barsouk

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1592 | Submission Open

Keywords: epidemiology; disparities; oncology; cancer; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma

edited by

Francesco E. Boccalatte

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1497 | Submission Open

Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation

(This special issue belongs to the Section Molecular Cancer Biology)

Gene and Cell Therapy for Cancers

edited by Jacquelyn J. Bower

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1472 | Submission Open

Keywords: cancer gene therapy; cell therapy; adeno-associated virus; lentivirus; immunotherapy; oncolytic viruses; cancer stem cells; targeted therapy; precision medicine

(This special issue belongs to the Section Cancer Therapy)

The Role of Apoptosis and Autophagy in Cancer

edited by

Souren Paul

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1466 | Submission Open

Keywords: apoptosis; cell death; tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by

Luca Giovanella

and Petra Petranović Ovčariček

submission deadline 31 Jul 2025 | 3 articles | Viewed by 1413 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors

edited by

Annabella Di Mauro

Ottavia Clemente

and

Salvatore Tafuto

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1376 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1287 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1113 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular and Cellular Heterogeneity in an Evolving Tumor Landscape: When Diversity Gives Rise to Aggressive and Drug-Resistant Cells (2nd Edition)

edited by

Michelle R. Dawson

submission deadline 31 Jul 2025 | 1 articles | Viewed by 570 | Submission Open

Keywords: single-cell analysis; intratumor heterogeneity; spatial heterogeneity; epithelial-to-mesenchymal transition (EMT); metastatic cancer cells; tumor microenvironment interactions; chemoresistant cell phenotypes; cancer stem cells; polyploidal giant cancer cells; therapy-induced senescence/dormancy

(This special issue belongs to the Section Molecular Cancer Biology)

Transcription Factors in Breast Cancer

edited by

Sarah Walker

submission deadline 31 Jul 2025 | Viewed by 551 | Submission Open

Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Metronomic Chemotherapy in Cancer Treatment

edited by

Piotr J. Wysocki

submission deadline 31 Jul 2025 | Viewed by 475 | Submission Open

Keywords: metronomic chemotherapy; solid tumors; breast cancer; gynecological cancer; genitourinary cancers; gastrointestinal cancers; lung cancer; combined cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Integrative Histopathological–Molecular–Computational Analysis of Primary Brain Tumors

edited by

Adriana Olar

submission deadline 31 Jul 2025 | Viewed by 443 | Submission Open

Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

Novel Diagnosis and Treatment Approaches in Pancreatic Cancer

edited by

Atsushi Masamune

submission deadline 31 Jul 2025 | Viewed by 403 | Submission Open

Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Palliative and Supportive Care in Cancers

edited by Ahmed Elsayem

submission deadline 31 Jul 2025 | Viewed by 382 | Submission Open

Keywords: palliative care; symptom distress; oncology; emergency medicine; critical care; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Displaying special issue 251-300 on page 6 of 22.

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