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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications

edited by

Mariarosaria Conte

submission deadline 30 Sep 2025 | Viewed by 246 | Submission Open

Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application

(This special issue belongs to the Section Tumor Microenvironment)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 30 Sep 2025 | Viewed by 238 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)

edited by Hiromichi Ito

submission deadline 30 Sep 2025 | Viewed by 228 | Submission Open

Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging

(This special issue belongs to the Section Cancer Therapy)

Melanoma: Pathology and Translational Research—2nd Edition

edited by

Alessio Giubellino

Carlos Torres-Cabala

and Jose A. Plaza

submission deadline 30 Sep 2025 | Viewed by 217 | Submission Open

Keywords: melanoma; histopathology; dermatopathology; molecular profiling; biomarkers; digital pathology; translational studies; cancer therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Artificial Intelligence Supporting Global Cancer Statistics: Incidence and Mortality

edited by Margherita Ferrante and

Gea Oliveri Conti

submission deadline 30 Sep 2025 | Viewed by 211 | Submission Open

Keywords: artificial intelligence; big data; cancer statistics; oncological prevention; incidence; mortality

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)

edited by

Erel Joffe

submission deadline 30 Sep 2025 | Viewed by 205 | Submission Open

Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Translational Medicine in Gastroenteropancreatic Neuroendocrine Neoplasias

edited by

Bertram Wiedenmann

submission deadline 30 Sep 2025 | Viewed by 205 | Submission Open

Keywords: translational medicine; multiomics; improved diagnostics and therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy in Lung Cancer: From a Technical Revolution to a Combination with New Systemic Approaches (2nd Edition)

edited by

Alessio Bruni

submission deadline 30 Sep 2025 | Viewed by 204 | Submission Open

Keywords: NSCLC; SCLC; radiation therapy; SBRT; adjuvant RT; immunotherapy; concomitant treatments; toxicities

(This special issue belongs to the Section Cancer Therapy)

Chronic Lymphocytic Leukemia: From Genetics and Epigenetics to Therapy

edited by

Spencer Bruce B. Gibson

submission deadline 30 Sep 2025 | Viewed by 200 | Submission Open

Keywords: chronic lymphocytic leukemia; gene mutations; p53; immunoglobulin mutational status; epigenetics; methylation; MBL; drug resistance; drug treatments; Notch signaling; anti-apoptotic genes; Bcl-2; BTK; microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Integrated Management of Cancer (2nd Edition)

edited by

Mustafa B. A. Djamgoz

and

Omer Kucuk

submission deadline 30 Sep 2025 | Viewed by 195 | Submission Open

Keywords: complementary medicine; epigenetics; diet; nutraceuticals; lifestyle; hemotherapy; radiotherapy; biological therapies; immunotherapy; nanotechnology; stem cells; repurposed drugs; combination treatments

(This special issue belongs to the Section Cancer Therapy)

Pheochromocytoma, Paraganglioma and Neuroblastoma: Focus on Genetics—the Never-Ending Story

edited by María Currás-Freixes

submission deadline 30 Sep 2025 | Viewed by 168 | Submission Open

Keywords: hypoxia; treatment; surveillance; metastasis; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Treatment of Hepatopancreatobiliary Cancers: Open Question, Challenge, and Future Directions (2nd Edition)

edited by

Francesco Giovinazzo

and

Stijn van Laarhoven

submission deadline 30 Sep 2025 | Viewed by 145 | Submission Open

Keywords: carcinoma; hepatocellular; liver neoplasms; transplant oncology; neoadjuvant and adjuvant therapy; artificial intelligence; cholangiocarcinoma; colorectal and non-colorectal liver metastasis; pancreatic neoplasms

(This special issue belongs to the Section Cancer Therapy)

Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling

edited by

Ewa Koscielniak

and

Monika Sparber-Sauer

submission deadline 30 Sep 2025 | Viewed by 123 | Submission Open

Keywords: soft tissue sarcoma; molecular profiling; cancer genomics; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Innovative Strategies and Techniques in Diagnosing, Treating and Surveying Soft Tissue Sarcomas

edited by H. Thomas Temple

submission deadline 30 Sep 2025 | Viewed by 111 | Submission Open

Keywords: sarcoma; soft tissue; pediatric; adult; biopsy; radiography; pathology; radiotherapy; surgery; molecular

(This special issue belongs to the Section Cancer Therapy)

Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours

edited by Crispin T. Hiley and Iain Phillips

submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open

Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR

(This special issue belongs to the Section Cancer Therapy)

Radiobiological Modelling in the New Era of Precision Radiation Oncology

edited by

Hamid Abdollahi

submission deadline 1 Oct 2025 | 4 articles | Viewed by 8089 | Submission Open

Keywords: radiobiological modelling; precision radiation oncology; radiation therapy; cancers

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer: Epidemiology, Management and New Therapies

edited by

Gerardo Cazzato

and Francesco Fortarezza

submission deadline 1 Oct 2025 | 2 articles | Viewed by 2431 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; adnexal tumor; metastatic cutaneous neoplasms; epidemiology; management; therapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Chromosomal Instability in Cancer: 2nd Edition

edited by

Henry H. Heng

submission deadline 1 Oct 2025 | 2 articles | Viewed by 2261 | Submission Open

Keywords: aneuploidy; cancer evolution; chromothripsis; chromosomal translocation; genome chaos; genome instability; heterogeneity; karyotype coding; polyploid giant cancer cells

(This special issue belongs to the Section Molecular Cancer Biology)

3D Cultures and Organoids in Cancer Research

edited by

Karla Rubio

and

César López-Camarillo

submission deadline 1 Oct 2025 | 1 articles | Viewed by 1387 | Submission Open

Keywords: 3D cell cultures; organotypic 3D cultures; 3D spheroids models; induced pluripotent stem (iPS); organoids; tumoroids

(This special issue belongs to the Section Molecular Cancer Biology)

Updates on Liver Cancer Management

edited by

Zenichi Morise

submission deadline 1 Oct 2025 | 1 articles | Viewed by 1359 | Submission Open

Keywords: laparoscopic liver resection; minimally invasive liver resection; deteriorated liver function; anatomical resection; preoperative simulation; intraoperative navigation; liver metastasis; hepatocellular carcinoma biliary tract cancers; robot-assisted liver resection

(This special issue belongs to the Section Cancer Therapy)

Exploring Immunotherapy in Colorectal Cancer

edited by

Alessandro Passardi

Luca Esposito

and

Chiara Gallio

submission deadline 1 Oct 2025 | Viewed by 224 | Submission Open

Keywords: colorectal cancer; immunotherapy; immune checkpoint inhibitors; mismatch repair; microsatellite instability; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Genomic Landscape of Gynecological Cancers

edited by

Tong Sun

submission deadline 1 Oct 2025 | Viewed by 120 | Submission Open

Keywords: gynecological cancers; tumor genomics; molecular profiling; precision oncology; targeted therapy; genetic alterations; multi-omics; tumor heterogeneity; biomarker discovery; translational research

(This special issue belongs to the Section Molecular Cancer Biology)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 1 Oct 2025 | Viewed by 105 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH; TERT; and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

Breast Cancer: Tailored Rehabilitation Strategies to Address the Challenge of Survivorship Issues

edited by

Marco Invernizzi

and

Lorenzo Lippi

submission deadline 3 Oct 2025 | 5 articles | Viewed by 24721 | Submission Open

Keywords: breast cancer; rehabilitation; biomarkers; survivorship; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Immunometabolic Disorders and Early-Onset Gastrointestinal Cancer: Etiology, Incidence, Survival and Disparities

edited by Yunxia Lu

submission deadline 3 Oct 2025 | Viewed by 121 | Submission Open

Keywords: immunometabolic disorders; early-onset gastrointestinal cancer; cancer etiology; cancer incidence; cancer screening; cancer disparities; cancer survival; type 2 diabetes; diet and nutrition; obesity; autoimmune diseases; metabolic syndrome

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Research on Soft Tissue Sarcomas

edited by

Shunji Takahashi

submission deadline 6 Oct 2025 | Viewed by 203 | Submission Open

Keywords: soft tissue sarcoma; chondrosarcoma; Ewing sarcoma; osteosarcoma; precision medicine; emphasizing detection; treatment; surgery; radiologic imaging

(This special issue belongs to the Section Cancer Therapy)

Digital Health Technologies in Oncology

edited by

Sorana D. BOLBOACĂ

submission deadline 10 Oct 2025 | 6 articles | Viewed by 10396 | Submission Open

Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions

edited by

Apriliana Kartikasari

submission deadline 10 Oct 2025 | 1 articles | Viewed by 847 | Submission Open

Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Near-Infrared Photoimmunotherapy for Cancer Treatment: 2nd Edition

edited by

Hisataka Kobayashi

submission deadline 10 Oct 2025 | Viewed by 154 | Submission Open

Keywords: NIR-PIT; phototherapy; monoclonal antibody; imaging biomarker; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Onco-Nephrology: From Molecular to Clinical Studies

edited by

Hans Kristian Lorenzo

submission deadline 12 Oct 2025 | Viewed by 367 | Submission Open

Keywords: acute kidney injury in oncology; chronic kidney disease and cancer; paraneoplastic glomerulonephritis; immunotherapy-related nephrotoxicity; tumor lysis syndrome; nephrotoxicity of chemotherapeutic agents; DNA damage; epigenetic modifications; molecular pathways in cancer-associated kidney injury; biomarkers for early detection of kidney injury

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer and Chronic Illness

edited by

Silvia Riondino

and

Vincenzo Formica

submission deadline 15 Oct 2025 | 7 articles | Viewed by 15836 | Submission Open

Keywords: cancer; chronic disease; inflammatory disease; cytokines; immune disease; radiotherapy-induced diseases; immunotherapy-induced disease; gastrointestinal chronic disorders; end-stage renal disease; lung cancer chronic disease

(This special issue belongs to the Section Cancer Pathophysiology)

New Precision Medicine Approaches in Haematological Malignancies: Novel Targets and Advanced Therapies (2nd Edition)

edited by

Ilaria Stefania Pagani

and

Teresa Sadras

submission deadline 15 Oct 2025 | 3 articles | Viewed by 10761 | Submission Open

Keywords: blood cancer; cancer relapse; resistance; targeted therapies; immune therapies; metabolism; cancer mutations

(This special issue belongs to the Section Methods and Technologies Development)

Imaging in Breast Cancer Diagnosis and Treatment

edited by

Tommaso Susini

and Jacopo Nori Cucchiari

submission deadline 15 Oct 2025 | 5 articles | Viewed by 9517 | Submission Open

Keywords: mammography; breast ultrasound; axillary ultrasound; breast MRI; contrast-enhanced mammography; digital breast thomosynthesis; thermoablation; crioablation

(This special issue belongs to the Section Cancer Therapy)

Bridging the Gap: Integrating AI into Clinical Practice for Oncological PET/CT Imaging

edited by Fereshteh Yousefirizi

submission deadline 15 Oct 2025 | 8 articles | Viewed by 8152 | Submission Open

Keywords: physician-in-the-loop; PET/CT; AI; foundation model; generalist model; tumor segmentation; outcome prediction; whole-body PET; cancers

(This special issue belongs to the Section Cancer Therapy)

Treatment of Peripheral T-cell Lymphomas

edited by

Raphael Koch

submission deadline 15 Oct 2025 | 4 articles | Viewed by 7276 | Submission Open

Keywords: T-cell lymphoma; PTCL; molecular targets; targeted therapy; immunotherapy; combination therapy; biomarker

(This special issue belongs to the Section Tumor Microenvironment)

De-escalation of Axillary and Breast Cancer Surgery in the Setting of Neo-Adjuvant Chemotherapy

edited by Corrado Tinterri and

Damiano Gentile

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3686 | Submission Open

Keywords: breast neoplasm; breast cancer; surgery; breast cancer surgery; systemic therapy; neo-adjuvant chemotherapy; axilla; axillary surgery; sentinel lymph node biopsy; de-escalation surgery

(This special issue belongs to the Section Cancer Therapy)

Targeting Pathogenic Variants in Hereditary Cancer Diagnosis and Screening

edited by Yanhong Liu

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3073 | Submission Open

Keywords: disease susceptibility; prognosis and outcomes; genetic association; genetic epidemiology; germline variants; pathogenic variants; rare variants; exome sequencing; whole genome sequencing; target sequencing

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Current Progress in the Clinical Management and Basic Science of Head and Neck Cancer

edited by

Takumi Kumai

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3042 | Submission Open

Keywords: head and neck cancer; immunotherapy; chemoradiotherapy; surgery; molecular biology; oncogenesis; cancer immunology

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advance in Colorectal Cancer Liver Metastases

edited by

Peter Metrakos

and Jennifer Kalil

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2877 | Submission Open

Keywords: colorectal cancer liver metastases; histological growth patterns; chemotherapy optimization; liver regeneration; future liver remnant; liquid biopsy; treatment resistance

(This special issue belongs to the Section Cancer Metastasis)

First-Line Therapy in Thoracic Oncology

edited by Antonio D'Andrilli and

Giulio Maurizi

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1833 | Submission Open

Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors

(This special issue belongs to the Section Cancer Therapy)

Inflammatory Bowel Disease and Cancers

edited by

Ferdinando D'Amico

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1548 | Submission Open

Keywords: inflammatory bowel disease; ulcerative colitis; Crohn’ s disease; cancer; malignancy

(This special issue belongs to the Section Cancer Therapy)

Endoscopic Management of Pancreatic Neoplasms (2nd Edition)

edited by

Nam Quoc Nguyen

submission deadline 15 Oct 2025 | 1 articles | Viewed by 1297 | Submission Open

Keywords: pancreatic cancer; pancreatic neoplasm; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; fine needle aspiration/biopsy; local treatment; biliary stent; biliary drainage; contrast enhancement

(This special issue belongs to the Section Methods and Technologies Development)

Treatments of Uveal Melanoma

edited by

Rumana N. Hussain

submission deadline 15 Oct 2025 | 1 articles | Viewed by 587 | Submission Open

Keywords: uveal melanoma; radiotherapy; radiation retinopathy; liver metastases; prognostication

(This special issue belongs to the Section Cancer Therapy)

Cutaneous Metastases: State-of-the-Art Research and Management

edited by Marios Papadakis and

Dimitra Koumaki

submission deadline 15 Oct 2025 | Viewed by 284 | Submission Open

Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes

(This special issue belongs to the Section Cancer Metastasis)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 15 Oct 2025 | Viewed by 229 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Radiomics and Molecular Biology in Glioma: A Synergistic Approach

edited by Anna Luisa Di Stefano and Gianluca Grimod

submission deadline 15 Oct 2025 | Viewed by 128 | Submission Open

Keywords: glioma; radiomics; molecular biology; MRI; PET; genomics; proteomics; liquid biopsy; personalized medicine; prognostic biomarkers

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods

edited by Peter C. Angeletti

submission deadline 15 Oct 2025 | Viewed by 48 | Submission Open

Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Liquid Biopsy in Cancer 2.0

edited by

Fabio Puglisi

Lorenzo Gerratana

and

Linda Cucciniello

submission deadline 20 Oct 2025 | 9 articles | Viewed by 23145 | Submission Open

Keywords: circulating biomarkers; clinical utility; circulating tumor DNA; circulating tumor cells; exosomes; circulating RNA; precision medicine

(This special issue belongs to the Section Cancer Therapy)

What’s behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification

edited by

Emanuele Perrone

submission deadline 20 Oct 2025 | 5 articles | Viewed by 13202 | Submission Open

Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical Treatment of Osteosarcoma

edited by

Masanori Okamoto

submission deadline 20 Oct 2025 | 4 articles | Viewed by 8080 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Displaying special issue 251-300 on page 6 of 23.

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