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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genome Instability and Human Cancer
edited by Jian Ouyang
submission deadline 15 Dec 2025 | 3 articles | Viewed by 9396 | Submission Open
Keywords: genomic instability; cancer progression; drug resistance; tumor-targeted immunity
(This special issue belongs to the Section Tumor Microenvironment)
Advances in B-Cell Lymphoma: From Diagnostics to Cure
edited by and Megan E. Melody
submission deadline 15 Dec 2025 | 4 articles | Viewed by 6019 | Submission Open
Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies
(This special issue belongs to the Section Cancer Therapy)
Endometrial Cancer—Diagnosis and Treatment submission deadline 15 Dec 2025 | 3 articles | Viewed by 3860 | Submission Open
Keywords: endometrial cancer; Lynch syndrome; oncology; sentinel lymph node; uterine cancer; molecular classification
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Outcome Analysis and Predictive Insights in Soft Tissue Sarcomas: leveraging Clinical Data and Integrating Modelling
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 3285 | Submission Open
Keywords: bone sarcomas; soft tissue sarcomas; outcome analysis; predictive modelling; prognostic biomarkers; therapeutic impact; clinical data integration; survivorship prediction; patient trajectories; sarcoma management
(This special issue belongs to the Section Methods and Technologies Development)
Incorporating DNA Damage Response (DDR) Mechanisms in Cancer Systems: 2nd Edition submission deadline 15 Dec 2025 | 1 articles | Viewed by 2755 | Submission Open
Keywords: complex DNA damage; methodologies for detection of DNA damage; DNA damage response (DDR) and repair; biological effects of radiation stress; oxidative stress; and replication stress; DDR and immune response; genomic instability; aging; bioinformatics and systems biology; machine learning and artificial intelligence; cancer survival and therapeutics; 3D bioprinting of cells and tissues
(This special issue belongs to the Section Molecular Cancer Biology)
Multicellular 3D Models of Cancer submission deadline 15 Dec 2025 | 1 articles | Viewed by 1766 | Submission Open
Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions
(This special issue belongs to the Section Methods and Technologies Development)
Signaling Pathways in Breast Cancer: 2nd Edition
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1765 | Submission Open
Keywords: angiogenesis; apoptosis; breast cancer metastasis; breast cancer stem cells; cancer invasion; chemoprevention; epithelial-to-mesenchymal transition; ERα /ERBB2/HER2/NFκ B/Notch3/TGFβ signaling; mammary carcinogenesis; mitochondrial dynamics; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Advances in Genomics and Molecular Diagnostics in Gynecological Pathology
edited by and
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1320 | Submission Open
Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Surgical Management of Non-Small Cell Lung Cancer
edited by József Furák
submission deadline 15 Dec 2025 | 1 articles | Viewed by 829 | Submission Open
Keywords: non-small cell lung cancer; surgery; treatment; segmentectomy
(This special issue belongs to the Section Cancer Therapy)
Thoracic Neuroendocrine Tumors and the Role of Emerging Therapies submission deadline 20 Dec 2025 | 4 articles | Viewed by 11055 | Submission Open
Keywords: thoracic neuroendocrine tumors; lung NETs; low-grade typical carcinoids; TCs; intermediate-grade atypical carcinoids; ACs; high-grade large cell neuroendocrine carcinoma LCNEC; small cell lung carcinoma (SCLC) neuroendocrine carcinoma
(This special issue belongs to the Section Cancer Therapy)
Optimizing Surgical Procedures and Outcomes in Renal Cancer
edited by and Piotr Kania
submission deadline 20 Dec 2025 | 5 articles | Viewed by 6367 | Submission Open
Keywords: renal cancer surgery; optimizing outcomes; minimally invasive techniques; surgical innovations; multidisciplinary approaches
(This special issue belongs to the Section Clinical Research of Cancer)
Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment
edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3273 | Submission Open
Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 2430 | Submission Open
Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management
(This special issue belongs to the Section Cancer Therapy)
Histopathology and Pathogenesis of Skin Cancer submission deadline 20 Dec 2025 | 2 articles | Viewed by 2334 | Submission Open
Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology
(This special issue belongs to the Section Cancer Pathophysiology)
Insights into the Pathogenesis of Cutaneous T-Cell Lymphoma and the Impact of These Potential Biomarkers on Future Diagnosis, Prognosis and Treatment
edited by Sean Whittaker
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1539 | Submission Open
Keywords: primary cutaneous T-cell lymphomas; CTCL; pathogenesis; biomarkers; diagnosis; prognosis; treatment
(This special issue belongs to the Section Cancer Biomarkers)
A Deeper Dive into Signaling Pathways in Cancers (2nd Edition)
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1217 | Submission Open
Keywords: signaling pathways; cancer; drug resistance; tumor microenvironment; molecularly targeted drug; epigenetic regulation; reverse-phase protein array
(This special issue belongs to the Section Tumor Microenvironment)
The Impact of Minimally Invasive Surgery on Gynecologic Cancers
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 910 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy
(This special issue belongs to the Section Cancer Therapy)
IBD-Associated Cancer
edited by Takayuki Ogino
submission deadline 20 Dec 2025 | Viewed by 256 | Submission Open
Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Translational Cancer Research in Multiple Myeloma, with a Focus on Immune Therapies and Novel Agents – “The Bench Behind the Bedside”
edited by Paul G. Richardson, and Shonali Midha
submission deadline 20 Dec 2025 | Viewed by 135 | Submission Open
Keywords: multiple myeloma; immune microenvironment; signaling pathways; therapeutic targets; immune effector cell therapies; monoclonal antibodies; targeted agents; mechanisms of action; resistance mechanisms; treatment
(This special issue belongs to the Section Cancer Therapy)
Metastasis Associated Long Noncoding RNAs in Cancer Research
edited by
submission deadline 21 Dec 2025 | Viewed by 306 | Submission Open
Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature
(This special issue belongs to the Section Cancer Metastasis)
Tumor Immune Microenvironment in Gastric Cancers submission deadline 25 Dec 2025 | 4 articles | Viewed by 16162 | Submission Open
Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages
(This special issue belongs to the Section Tumor Microenvironment)
Study on Epidemiology of Childhood Cancer submission deadline 25 Dec 2025 | 5 articles | Viewed by 10279 | Submission Open
Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Ovarian Cancer Research and Treatment: 2nd Edition
edited by
submission deadline 25 Dec 2025 | 3 articles | Viewed by 4536 | Submission Open
Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets
(This special issue belongs to the Section Cancer Therapy)
Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer
edited by and Christian Thomas
submission deadline 25 Dec 2025 | 3 articles | Viewed by 4046 | Submission Open
Keywords: robotic-assisted radical prostatectomy; significance of pelvic lymph node dissection in the context of radical prostatectomy; complications of surgical therapy for prostate cancer; magnetic resonance imaging/ultrasound-guided target biopsy of the prostate; comparison of various robotic systems for radical prostatectomy; learning curves; hospital volume; prostate cancer centers
(This special issue belongs to the Section Clinical Research of Cancer)
Epigenetics in Endocrine-Related Cancer
edited by Jennie N Jeyapalan
submission deadline 25 Dec 2025 | 1 articles | Viewed by 1448 | Submission Open
Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Blood Cancers: How We Define Success submission deadline 25 Dec 2025 | 1 articles | Viewed by 1056 | Submission Open
Keywords: blood cancers; research-driven advancements; cure rates; novel agents
(This special issue belongs to the Section Cancer Therapy)
Measurable Residual Disease in Cancer: 2nd Edition
edited by Krzysztof Jamroziak and
submission deadline 25 Dec 2025 | Viewed by 169 | Submission Open
Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques
(This special issue belongs to the Section Cancer Drug Development)
Predictive Biomarkers for Lung Cancer
edited by Ole Hilberg
submission deadline 30 Dec 2025 | 10 articles | Viewed by 22022 | Submission Open
(This special issue belongs to the Section Cancer Biomarkers)
Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5462 | Submission Open
Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances in Hematological Malignancies in Children
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 3311 | Submission Open
Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies
(This special issue belongs to the Section Pediatric Oncology)
Understanding the Complexities of Anticancer Drugs Resistance submission deadline 30 Dec 2025 | 2 articles | Viewed by 3222 | Submission Open
(This special issue belongs to the Section Cancer Drug Development)
Transcription Factors in Breast Cancer
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 2730 | Submission Open
Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms
edited by Francesco Santullo and Agostino Maria De Rose
submission deadline 30 Dec 2025 | 2 articles | Viewed by 2416 | Submission Open
Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
Palliative Radiotherapy for Cancer
edited by Rebecca Wong
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1791 | Submission Open
Keywords: symptom relief; symptom control; radiation medicine; radiotheranostics; theranostics; external beam radiotherapy; palliation; oligometastases; oligoprogression; systematic reviews and meta-analyses; patient reported outcomes; abscopal effect; combined modality; education; clinical practice
(This special issue belongs to the Section Cancer Therapy)
Combination Therapy in Geriatric Population with Cancer (2nd Edition)
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1454 | Submission Open
Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer submission deadline 30 Dec 2025 | Viewed by 535 | Submission Open
Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Trials for Thoracic Cancers
edited by
submission deadline 30 Dec 2025 | Viewed by 137 | Submission Open
Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma
(This special issue belongs to the Section Clinical Research of Cancer)
Insights from the Editorial Board Member
edited by
submission deadline 31 Dec 2025 | 46 articles | Viewed by 89422 | Submission Open
Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics
Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management submission deadline 31 Dec 2025 | 18 articles | Viewed by 36860 | Submission Open
Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cervical Cancer: Screening and Treatment in 2024-2025 submission deadline 31 Dec 2025 | 7 articles | Viewed by 28707 | Submission Open
Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Disparities in Cancer Prevention, Screening, Diagnosis and Management
edited by
submission deadline 31 Dec 2025 | 17 articles | Viewed by 27509 | Submission Open
Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Skin Cancer: Diagnosis, Treatment and Prognosis
edited by Iris Zalaudek and
submission deadline 31 Dec 2025 | 13 articles | Viewed by 25533 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Integrating Palliative Care in Oncology submission deadline 31 Dec 2025 | 10 articles | Viewed by 24228 | Submission Open
Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
PTEN: Regulation, Signalling and Targeting in Cancer submission deadline 31 Dec 2025 | 7 articles | Viewed by 22616 | Submission Open
Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
Advanced Diagnostics and Optical Imaging Technologies in Cancer Research
edited by Vlad Mihai Voiculescu
submission deadline 31 Dec 2025 | 12 articles | Viewed by 21570 | Submission Open
Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies
(This special issue belongs to the Section Methods and Technologies Development)
Oncology: State-of-the-Art Research and Initiatives in Japan submission deadline 31 Dec 2025 | 8 articles | Viewed by 20059 | Submission Open
Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support
New Perspectives in the Management of Breast Cancer submission deadline 31 Dec 2025 | 11 articles | Viewed by 19824 | Submission Open
Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact
(This special issue belongs to the Section Cancer Therapy)
Novel Therapeutic Strategies in Salivary Gland Tumor submission deadline 31 Dec 2025 | 8 articles | Viewed by 18445 | Submission Open
Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging
(This special issue belongs to the Section Cancer Therapy)
Oral Potentially Malignant Disorders and Oral Cavity Cancer
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 18251 | Submission Open
Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine
(This special issue belongs to the Section Cancer Therapy)
Medical Imaging and Artificial Intelligence in Cancer
edited by Debiao Li and
submission deadline 31 Dec 2025 | 10 articles | Viewed by 15129 | Submission Open
Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization
(This special issue belongs to the Section Methods and Technologies Development)
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