Tumorigenesis and Tumor Microenvironment—Insights and Interventions (TTMII)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 3
Special Issue Editors
Interests: tumorigenesis; tumor microenvironment; intervention; stress biology; aging; mortalin; CARF; ashwagandha; propolis and natural compounds
Interests: tumorigenesis; tumor microenvironment; intervention; imaging; stress biology; cell biology; aging; mortalin; CARF; ashwagandha; natural compounds
Interests: tumorigenesis; tumor microenvironment; oral cancer; molecular biology; cancer signaling; curcumin; natural compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer development is a complex, multistage process involving not only genetic and molecular alterations within tumor cells but also significant changes in the surrounding tumor microenvironment (TME). The TME, comprising immune cells, stromal components, blood vessels, signaling molecules, and extracellular matrix, plays a pivotal role in tumor initiation, progression, metastasis, resistance to therapy, and recurrence. Despite growing evidence emphasizing its importance, our understanding of the TME remains incomplete. Most recently, the molecular link between stress, aging, and cancer has been elucidated. Accordingly, stress and aging interventions are predicted to have therapeutic and preventive benefits in cancer management. Critical insights are still needed to elucidate the molecular mechanisms governing tumorigenesis, TME interactions, and their link to stress and aging, which could lead to the identification of novel biomarkers and therapeutic targets. Ongoing research aims to characterize such dynamic molecular signatures within stress, aging, and TME signaling and to develop strategies that can effectively modulate these elements for therapeutic gain. Although several therapeutic interventions have been designed to target the TME, such as angiogenesis inhibitors, immune checkpoint inhibitors, and stromal modulators, significant challenges persist regarding specificity, efficacy, and resistance. Therefore, this Special Issue aims to highlight the latest advances in tumorigenesis and tumor microenvironment research, with a focus on innovative strategies for therapeutic targeting. By deepening our understanding of tumorigenesis and TME dynamics and their link to stress and aging, this collection seeks to pave the way for the development of more precise and effective cancer therapies.
Prof. Dr. Renu Wadhwa
Dr. Sunil C. Kaul
Prof. Dr. Ajaikumar B. Kunnumakkara
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumorigenesis
- tumor microenvironment
- intervention
- stress biology
- aging
- mortalin
- CARF
- ashwagandha
- propolis
- curcumin
- natural compounds
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