Pheochromocytoma and Paraganglioma: Molecular Insights and Clinical Frontiers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 3
Special Issue Editor
Interests: neuroendocrine tumors; pheochromocytoma and paraganglioma; endocrinology; oncology; nuclear medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla or extra-adrenal paraganglia. Although infrequent, they pose substantial diagnostic and therapeutic challenges due to their heterogeneous biochemical activity, unpredictable clinical course, and frequent association with hereditary syndromes. Advances in molecular genetics have uncovered a growing number of germline and somatic mutations, illuminating the diverse pathways involved in PPGL tumorigenesis and offering new opportunities for targeted interventions.
Recent years have also witnessed remarkable progress in functional imaging, molecular diagnostics, and radionuclide-based therapies. The emergence of novel targeted agents, such as hypoxia-inducible factor 2 alpha (HIF-2α) inhibitors, highlights the transition toward precision oncology in PPGL management. Moreover, an improved understanding of genotype–phenotype correlations has enabled refined risk stratification, tailored surveillance, and personalized treatment strategies.
This Special Issue of Cancers will present cutting-edge research spanning molecular mechanisms, genetic profiling, diagnostic innovations, and therapeutic advances in PPGLs. We welcome multidisciplinary contributions from the fields of endocrinology, oncology, genetics, radiology, pathology, nuclear medicine, and surgery. By bridging molecular insights and clinical practice, this Special Issue will advance knowledge, foster collaboration, and improve outcomes for patients with pheochromocytoma and paraganglioma.
Dr. Ivana Jochmanová
Guest Editor
Manuscript Submission Information
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Keywords
- pheochromocytoma and paraganglioma
- hereditary cancer syndromes
- genetic mutations
- genotype–phenotype correlations
- functional imaging
- molecular diagnostics
- biomarkers
- precision oncology
- targeted therapy
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