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Cancers
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Clinical and Translational Research of Prostate Cancer
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Clinical and Translational Research of Prostate Cancer

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 866

Editor

Prof. Dr. Nathan Lawrentschuk

E-Mail Website
Guest Editor
1. Department of Urology, The Royal Melbourne Hospital, 300 Grattan St, Parkville, VIC 3052, Australia
2. Division of Cancer Services, Peter MacCallum Cancer Centre, Parkville, VIC 3052, Australia
3. Department of Surgery, The University of Melbourne, Parkville, VIC, Australia
4. EJ Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC, Australia
Interests: urological cancer surgery; prostate cancer; kidney cancer; bladder cancer

Special Issue Information

Dear Colleagues,

Prostate cancer research is increasingly focused on translational biological, imaging, and diagnostic advances into clinically meaningful improvements in patient care. While molecular and technological innovations have reshaped risk stratification, detection, and treatment pathways, their real-world implementation, clinical impact, and policy implications remain poorly defined. This Special Issue will highlight clinical and translational research that bridges discovery with clinical practice, including advances in early detection, diagnostic and imaging pathways, treatment optimization, biomarkers with clinical applicability, and health-system and policy evaluation. The aim of this Special Issue is to showcase work that informs clinical decision-making and improves outcomes across the prostate cancer care continuum.

Prof. Dr. Nathan Lawrentschuk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • translational research
  • clinical pathways
  • precision medicine
  • screening and diagnosis
  • real-world evidence
  • health policy
  • diagnostics

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Published Papers (1 paper)

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Research

11 pages, 702 KB  
Article
Positive Margin Location and Prostate Biopsy Route: A Consecutive Cohort Comparison of Transperineal and Transrectal Techniques
by Abdullah Al-Khanaty, Kieran Sandhu, Marian S. Wettstein, Tess Howard, Modher Al-Shawi, William Nolan, Marlon Perera, Nathan Lawrentschuk, Cédric Poyet, Damien Bolton and Gregory Jack
Cancers 2026, 18(5), 849; https://doi.org/10.3390/cancers18050849 - 6 Mar 2026
Viewed by 616
Abstract
Background: Transperineal (TP) prostate biopsy is increasingly used due to its superior infectious safety and enhanced sampling of anterior and apical prostate regions. Concerns have been raised that TP biopsy may induce greater post-biopsy fibrosis, particularly at the apex, potentially increasing positive [...] Read more.
Background: Transperineal (TP) prostate biopsy is increasingly used due to its superior infectious safety and enhanced sampling of anterior and apical prostate regions. Concerns have been raised that TP biopsy may induce greater post-biopsy fibrosis, particularly at the apex, potentially increasing positive surgical margin (PSM) rates at radical prostatectomy (RP). We evaluated whether biopsy technique influences overall or location-specific PSMs at RP. Methods: We performed a retrospective comparative cohort study of 1027 consecutive men who underwent TR biopsy and TP biopsy at our institution as we transitioned from TR to TP diagnostic technique. Patients from this cohort who were subsequently diagnosed with clinically localised prostate cancer and underwent RP were analysed. Clinical, biopsy, and pathological data were collected; all Gleason scores were standardised to Prognostic Grade Groups. PSMs were defined as tumour at the inked margin and categorised as apical, lateroposterior, or basal. Associations between biopsy technique and PSM outcomes were analysed using uni- and multivariable logistic regression. Results: Among 1027 biopsies, 260 men proceeded to RP, including 114 following TP biopsy and 146 following TR biopsy. Baseline pathological characteristics were similar between groups. Overall PSM rates did not differ between TP and TR cohorts (38.6 percent vs. 41.8 percent, p = 0.604). Margin location was also comparable at the apex (11.9 percent vs. 13.5 percent), lateroposterior (5.4 percent vs. 10.8 percent), and base (4.2 percent vs. 5.8 percent) respectively. In adjusted analyses controlling for age, PSA, grade, tumour stage, nodal status, and surgical approach, biopsy technique was not associated with overall PSMs (OR 0.70; 95 percent CI 0.39–1.24; p = 0.22) or with any location-specific PSMs. Conclusions: TP biopsy did not increase the risk of positive surgical margins at radical prostatectomy, either overall or at the apex. These findings do not support concerns that TP biopsy disrupts apical tissue planes or compromises oncologic outcomes. The results reinforce the safety of TP biopsy as a contemporary diagnostic standard, while highlighting the need for larger prospective studies to confirm these observations. Full article
(This article belongs to the Special Issue Clinical and Translational Research of Prostate Cancer)
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