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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Clinical Management of Genitourinary Tumors
edited by and Markus Graf
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1208 | Submission Open
Keywords: urogenital neoplasms; prostatic neoplasms; kidney neoplasms; ureteral neoplasms; urethral neoplasms; testicular neoplasms; urinary bladder neoplasms; disease management; artificial intelligence; precision medicine
(This special issue belongs to the Section Clinical Research of Cancer)
Cancer Screening and Primary Care
edited by Marievelisse Soto-Salgado
submission deadline 31 Oct 2025 | 1 articles | Viewed by 949 | Submission Open
Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Chemoprevention Advances in Cancer (2nd Edition)
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 937 | Submission Open
Keywords: cancer prevention; chemoprevention; nutrition and cancer; bio-active food components; natural products; non-toxic anticancer agents; precision nutrition in cancer; tumor metabolomics; gut microbiome in cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Skin Cancer Diagnostics and Therapy: Research and Clinical Studies (2nd Edition)
edited by Cristel Ruini
submission deadline 31 Oct 2025 | 1 articles | Viewed by 784 | Submission Open
Keywords: non-melanoma skin cancer; melanoma; actinic keratosis; field cancerisation; medical diagnostics; dermatology; dermoscopy; optical coherence tomography; in vivo confocal microscopy; ex vivo confocal microscopy; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 616 | Submission Open
Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries
(This special issue belongs to the Section Methods and Technologies Development)
New Strategies for the Treatment of Melanoma and Non-Melanoma Skin Cancer submission deadline 31 Oct 2025 | 1 articles | Viewed by 370 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; immunotherapy; anti-PD-1 antibody; BRAF/MEK inhibitors; racial differences; prognosis
(This special issue belongs to the Section Cancer Therapy)
MicroRNA (miRNA) in Cancers
edited by and Elmar Stickeler
submission deadline 31 Oct 2025 | Viewed by 362 | Submission Open
Keywords: miRNAs; cancer; diagnostics; tumor progression; metastasis; therapeutic targets; personalized medicine; pathways
(This special issue belongs to the Section Molecular Cancer Biology)
Recent Updates and Future Perspectives of Anti-Cancer Agents submission deadline 31 Oct 2025 | 1 articles | Viewed by 309 | Submission Open
Keywords: cancer; anti-cancer agents; targeted therapy; drug resistance; therapeutic agents; natural compounds; combination therapy; nanotherapy; translational therapy; immunotherapy
(This special issue belongs to the Section Cancer Drug Development)
Cancer Inhibitory Receptors and Related Cancer Immunotherapy
edited by Keqiang Chen, Feng Zhu and Xin Li
submission deadline 31 Oct 2025 | Viewed by 254 | Submission Open
Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Role of Nutrients in Cancer Progression
edited by
submission deadline 31 Oct 2025 | Viewed by 250 | Submission Open
Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Lung Cancer: Updates on Therapy and Prognostic Prediction
edited by Servet Bölükbas
submission deadline 31 Oct 2025 | Viewed by 231 | Submission Open
Keywords: lung cancer; targeted therapy; immunotherapy; prognostic prediction; precision medicine; biomarkers; artificial intelligence; next-generation sequencing; personalized treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Epigenetic Regulators and Cancer Precision Therapies
edited by Biaoru Li
submission deadline 31 Oct 2025 | Viewed by 218 | Submission Open
Keywords: tumorigenesis; epigenetics; epigenomics; personalized therapy
(This special issue belongs to the Section Cancer Therapy)
Heme Metabolism in Oncogenesis and Tumor Microenvironment: Mechanisms and Emerging Therapeutic Strategies
edited by Rays H.Y. Jiang and Gloria C. Ferreira
submission deadline 31 Oct 2025 | Viewed by 214 | Submission Open
Keywords: heme metabolism; oncogenesis; tumor microenvironment; porphyrin biosynthesis; redox homeostasis; cancer metabolism; heme biosynthesis pathways; CRISPR screening; iron metabolism; therapeutic targeting of heme pathways
(This special issue belongs to the Section Tumor Microenvironment)
Proton and Light Ion Therapy for Cancer
edited by Oliver Jäkel
submission deadline 31 Oct 2025 | Viewed by 195 | Submission Open
Keywords: novel beam delivery concepts; image guidance; adaptive therapy; in vivo monitoring; radiobiological studies with protons and light ions; clinical studies; outcome reports
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers
edited by Ting-Tai Yen and Eugene Patrick Toy
submission deadline 31 Oct 2025 | 1 articles | Viewed by 185 | Submission Open
Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Early Diagnosis and Minimally Invasive Management in Breast Cancer submission deadline 31 Oct 2025 | Viewed by 169 | Submission Open
Keywords: precision medicine; breast cancer prevention; cancer detection; early diagnosis; therapeutic strategies; artificial intelligence; image analysis; risk predictors
(This special issue belongs to the Section Methods and Technologies Development)
Pathology of Gynecological Cancers (2nd Edition)
edited by
submission deadline 31 Oct 2025 | Viewed by 167 | Submission Open
Keywords: endometrial cancer; ovarian cancer; vulvar cancer; cervical cancer; vaginal cancer
(This special issue belongs to the Section Cancer Pathophysiology)
The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment submission deadline 31 Oct 2025 | Viewed by 154 | Submission Open
Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Childhood Cancer in the Genomic Era: Experimental and Theoretical Approaches (2nd Edition)
edited by
submission deadline 31 Oct 2025 | Viewed by 113 | Submission Open
Keywords: microarrays; NGS; mutation analysis; CNV; epigenetics; modeling; mathematical models; physical models
(This special issue belongs to the Section Molecular Cancer Biology)
Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery
edited by
submission deadline 31 Oct 2025 | Viewed by 112 | Submission Open
Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening
(This special issue belongs to the Section Cancer Drug Development)
Discoveries in Targeted Therapies for Melanoma: From Molecular Mechanisms to Therapeutics
edited by Georg Thomas Wondrak
submission deadline 1 Nov 2025 | 2 articles | Viewed by 3919 | Submission Open
Keywords: malignant melanoma; cutaneous melanoma; uveal melanoma; drug resistance; targeted therapeutics; immune checkpoint inhibitors; targeted therapeutics; BRAF inhibitors; MEK inhibitors; drug discovery; molecular targets; melanoma diagnostics; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Advances in Thoracic Oncology Research
edited by
submission deadline 1 Nov 2025 | 1 articles | Viewed by 2408 | Submission Open
Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Prostate Biopsy: From Innovative Imaging Modalities to Optimized Detection Strategies
edited by
submission deadline 1 Nov 2025 | 1 articles | Viewed by 426 | Submission Open
Keywords: prostate biopsy; PSMA PET; systematic biopsies; targeted biopsies; transrectal biopsies; transperineal biopsies; cost-effectiveness; perilesional biopsy; PCa detection; imaging modalities
(This special issue belongs to the Section Methods and Technologies Development)
Targeting TGF-β as a Marker and Pharmacological Target against Cancer
edited by
submission deadline 1 Nov 2025 | Viewed by 383 | Submission Open
Keywords: TGF-β ; cancer; tumorigenesis; metastasis; epithelial– mesenchymal transition (EMT); marker; therapy
(This special issue belongs to the Section Tumor Microenvironment)
Neuro-Immune Orchestration in Brain Tumors: From Molecular Signatures to Therapeutic Innovation
edited by , Masasuke Ohno and Shunichiro Kuramitsu
submission deadline 1 Nov 2025 | Viewed by 198 | Submission Open
Keywords: neuro-immunology; brain tumor microenvironment; immunotherapy; molecular signatures; tumor-immune interactions
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth
edited by
submission deadline 1 Nov 2025 | Viewed by 175 | Submission Open
Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction
(This special issue belongs to the Section Cancer Biomarkers)
Targeted Therapy for Liver Metastases submission deadline 1 Nov 2025 | Viewed by 168 | Submission Open
Keywords: targeted therapy; liver metastases; biological therapy
(This special issue belongs to the Section Cancer Therapy)
Novel Research on the Diagnosis and Treatment of Melanoma
edited by Roberta Giuffrida, Stefania Guida, and
submission deadline 5 Nov 2025 | 3 articles | Viewed by 4239 | Submission Open
Keywords: melanoma; diagnosis; treatment; nevi; noninvasive imaging; targeted therapy; targeted diagnosis; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Advancing Hepatocellular Imaging: Innovations in Diagnosis, Prognosis, and Treatment Response Assessment
edited by and Fatima Zohra Mokrane
submission deadline 5 Nov 2025 | Viewed by 484 | Submission Open
Keywords: hepatocellular imaging; diagnosis; prognosis; treatment
(This special issue belongs to the Section Cancer Therapy)
Advances of Particle Therapy in Prostate Cancer—2nd Edition
edited by
submission deadline 5 Nov 2025 | Viewed by 190 | Submission Open
Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT
(This special issue belongs to the Section Cancer Therapy)
Advances in Medical Imaging for Cancer Detection and Diagnosis
edited by Claudia R. Mello-Thoms and Mark Anastasio
submission deadline 7 Nov 2025 | 1 articles | Viewed by 1977 | Submission Open
Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Interventional Oncology: Advances in Cancer Care
edited by
submission deadline 7 Nov 2025 | 1 articles | Viewed by 1841 | Submission Open
Keywords: interventional oncology; image guided; cancer care; quality of life
(This special issue belongs to the Section Methods and Technologies Development)
Hematological Malignancie: Progress and Challenges
edited by Lucas Coelho Arruda and Arwen Stikvoort
submission deadline 7 Nov 2025 | Viewed by 145 | Submission Open
Keywords: hematological malignancies; blood cancers; leukemia; lymphoma; multiple myeloma; immunotherapy; CAR-T-cell therapy; stem cell therapies; cell-based treatments; patient outcomes; immunoregulation; personalized medicine; molecular pathways; clinical Immunology
(This special issue belongs to the Section Cancer Therapy)
Upper Tract Urothelial Carcinoma: Current Knowledge and Perspectives
edited by Katie S. Murray and Saum Ghodoussipour
submission deadline 10 Nov 2025 | 2 articles | Viewed by 1408 | Submission Open
Keywords: upper tract urothelial carcinoma; upper tract disease; urothelial cell carcinoma
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapy of Pediatric Cancer (2nd Edition) submission deadline 10 Nov 2025 | Viewed by 192 | Submission Open
Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies
(This special issue belongs to the Section Pediatric Oncology)
Advances in Pleural and Peritoneal Mesothelioma
edited by
submission deadline 10 Nov 2025 | Viewed by 174 | Submission Open
Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression
(This special issue belongs to the Section Molecular Cancer Biology)
Genetics in Hematological Malignancies
edited by
submission deadline 10 Nov 2025 | Viewed by 136 | Submission Open
Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy submission deadline 10 Nov 2025 | Viewed by 130 | Submission Open
Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention
(This special issue belongs to the Section Molecular Cancer Biology)
Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment
edited by Luca Milone and Abid Qureshi
submission deadline 14 Nov 2025 | Viewed by 25 | Submission Open
Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Outcomes in Urologic Cancers
edited by and Pierre Karakiewicz
submission deadline 15 Nov 2025 | 15 articles | Viewed by 33471 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Breast Cancer: Biomarkers of Diagnosis and Prognosis
edited by and Sarah J. Storr
submission deadline 15 Nov 2025 | 8 articles | Viewed by 11012 | Submission Open
Keywords: breast cancer; biomarker; diagnosis; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Brain Metastases: From Mechanisms to Treatment
edited by Dawen Zhao and Michael Chan
submission deadline 15 Nov 2025 | 7 articles | Viewed by 9775 | Submission Open
Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy
(This special issue belongs to the Section Cancer Metastasis)
Benign and Malignant Neoplasms of the Head and Neck
edited by Charles C. L. Tong and Brett A. Miles
submission deadline 15 Nov 2025 | 4 articles | Viewed by 6765 | Submission Open
Keywords: laryngeal cancer; oral cavity and oropharynx cancer; nasal cavity and paransal sinus cancer; anterior and lateral skull base cancer; salivary gland cancer; melanoma
(This special issue belongs to the Section Cancer Therapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 15 Nov 2025 | 3 articles | Viewed by 3913 | Submission Open
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Radiotherapy for Thoracic Malignancies: New Advances and Challenges: 2nd Edition
edited by
submission deadline 15 Nov 2025 | 3 articles | Viewed by 3089 | Submission Open
Keywords: radiotherapy; stereotactic body radiation therapy; non-small cell lung cancer; immunotherapy; thoracic oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiomic, Genomic and Radiogenomic Techniques in Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2353 | Submission Open
Keywords: medulloblastoma; pediatrics; radiomics; genomics; segmentation; deep learning; classification; risk-stratification; molecular subgroups
(This special issue belongs to the Section Cancer Therapy)
Overcoming Pitfalls in the Detection and Definition of Clinically Significant Prostate Cancer: Strategies to Improve Screening and Diagnosis
edited by
submission deadline 15 Nov 2025 | 2 articles | Viewed by 1996 | Submission Open
Keywords: prostate cancer; PSA; magnetic resonance of the prostate; prostatic tissue-based biomarkers; prostate biopsy; prostate cancer screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Therapeutic Approaches Targeting Pediatric and Adult Glioma
edited by Siddhartha Mitra and
submission deadline 15 Nov 2025 | 1 articles | Viewed by 1492 | Submission Open
Keywords: glioma; high-grade glioma; glioblastoma; DIPG; ependymoma; immunotherapy; targeted therapy; combination therapies; small-molecule inhibitors
(This special issue belongs to the Section Cancer Therapy)
Nanomedicine and Nanobiotechnology in Cancer submission deadline 15 Nov 2025 | Viewed by 523 | Submission Open
Keywords: nanomedicine; nanobiotechnology; nanodevices; nanoimaging; 3D models; drug delivery; nanotechnologies for translational medicine; pre-clinical and clinical phases; from bench to bedside
(This special issue belongs to the Section Methods and Technologies Development)
Minimally Invasive Gastric Cancer Surgery
edited by , Simone Giacopuzzi and Felix Berlth
submission deadline 15 Nov 2025 | Viewed by 325 | Submission Open
Keywords: gastric cancer; laparoscopy; robotic surgery; fluorescence; minimally invasive surgery; lymphadenectomy
(This special issue belongs to the Section Cancer Therapy)
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