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Advances in Acute Lymphoblastic Leukemia Treatment

A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 1294

Editor


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Guest Editor
Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA 92697, USA
Interests: oncology; immunology; chemotherapy

Special Issue Information

Dear Colleagues,

Although Acute Lymphoblastic Leukemia (ALL) is primarily recognized as the most prevalent pediatric malignancy, it presents a significant clinical challenge in the adult population. While pediatric cure rates have reached 90% through standard chemotherapy, adult outcomes remain suboptimal at approximately 50%, largely due to high relapse rates and emergent drug resistance. A definitive consensus on the management of newly diagnosed adults—specifically the elderly—has yet to be established.

The purpose of this Special Issue is to explore diverse treatment options and significant clinical advances made in recent years. We invite submissions of original research articles and comprehensive reviews that contribute to our understanding of this evolving landscape.

Dr. Roberta Buono
Guest Editor

Manuscript Submission Information

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Keywords

  • acute lymphoblastic leukemia
  • biology
  • clinical trial
  • treatment
  • chemotherapy
  • immunotherapy

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Published Papers (1 paper)

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Review

16 pages, 2011 KB  
Review
Olverembatinib: A New Treatment for Adult Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
by Xavier Thomas
Cancers 2026, 18(12), 1990; https://doi.org/10.3390/cancers18121990 - 18 Jun 2026
Viewed by 938
Abstract
Background/Objectives: The prognosis of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has improved with the addition of tyrosine kinase inhibitors (TKIs) to conventional chemotherapy. However, there are limited therapeutic options for patients resistant or intolerant to current TKIs. Methods: [...] Read more.
Background/Objectives: The prognosis of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has improved with the addition of tyrosine kinase inhibitors (TKIs) to conventional chemotherapy. However, there are limited therapeutic options for patients resistant or intolerant to current TKIs. Methods: A comprehensive search was made on PubMed.ncbi.nlm.nih.gov for published studies and ClinicalTrials.gov for registered trials, regarding the first results of and promising strategies with olverembatinib, a novel third-generation TKI, for the treatment of Ph+ ALL. Results: First trials involving olverembatinib showed significant anti-leukemic clinical activity both in newly diagnosed and relapsed/refractory patients with Ph+ ALL, especially those harboring the T315I mutation. Furthermore, olverembatinib demonstrated a favorable tolerability compared with the other TKIs. Conclusions: This augurs a new era in the standard of care for many patients with unmet clinical needs. However, further studies are warranted to assess olverembatinib’s real value and its cost-effectiveness. Full article
(This article belongs to the Special Issue Advances in Acute Lymphoblastic Leukemia Treatment)
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