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Cancers
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Innovations in Colorectal Cancer
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Innovations in Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 884

Special Issue Editor

Dr. Sandy Hwang Fang

E-Mail Website
Guest Editor
Department of Surgery, Oregon Health & Science University, Portland, OR, USA
Interests: colon cancer; rectal cancer; surgery

Special Issue Information

Dear Colleagues,

Colorectal cancer treatment has rapidly evolved over the last decade. Minimally invasive surgical innovations, including robotic and transanal surgical modalities, have been enabled by remarkable developments in medical oncology alongside progressive approaches to radiation delivery. Total neoadjuvant therapy and immunotherapy have paved the way for organ preservation and the potential for rectal sparing operative interventions.

As the Guest Editor of the Special Issue for the journal Cancers, I would like to invite you to contribute a paper focusing on “Current Perspectives in Colorectal Cancer.” The objective of this Special Issue is to highlight any basic/translational science and clinical research advances in colorectal surgery, surgical oncology, medical oncology, and radiation oncology.

Thank you for your consideration.

Dr. Sandy Hwang Fang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colon cancer
  • rectal cancer
  • innovation
  • clinical trials
  • total neoadjuvant therapy
  • medical oncology
  • radiation oncology

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Published Papers (1 paper)

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Research

18 pages, 2337 KB  
Article
Polyploid and Chromosomal Copy Number Gain Cells in Metastatic Colon Cancer: Exploratory Genotype–Phenotype Correlations
by Alessandro Ottaiano, Federica Zito Marino, Monica Ianniello, Giuliana Ciappina, Enrica Toscano, Antonio Ieni, Stefano Lucà, Roberto Sirica, Enrica Maiorana, Salvatore Berretta, Nadia Di Carluccio, Michele Caraglia, Giovanni Savarese, Renato Franco and Massimiliano Berretta
Cancers 2026, 18(6), 994; https://doi.org/10.3390/cancers18060994 - 19 Mar 2026
Viewed by 592
Abstract
Background: Polyploid and chromosomal copy number gains (CNGs) cells may serve as key mediators of tumor plasticity, therapeutic resistance, and clonal evolution. Despite growing interest, their biological and clinical relevance in colorectal cancer, particularly in the metastatic setting, remains poorly defined. Methods: We [...] Read more.
Background: Polyploid and chromosomal copy number gains (CNGs) cells may serve as key mediators of tumor plasticity, therapeutic resistance, and clonal evolution. Despite growing interest, their biological and clinical relevance in colorectal cancer, particularly in the metastatic setting, remains poorly defined. Methods: We performed an integrated morphological, cytogenetic, and genomic analysis of metastatic colon cancer. A tissue microarray comprising 100 tumors was evaluated, of which 47 cases were fully assessable for morphology and fluorescence in situ hybridization (FISH). Polyploid nuclei and chromosomal CNGs were assessed morphologically and cytogenetically. High-resolution targeted sequencing (TruSight Oncology 500) was conducted to characterize genomic alterations. Bioinformatic analyses included Gene Ontology enrichment and Phenolyzer network modeling. Associations with clinicopathological variables and survival outcomes were explored. Results: Polyploid nuclei and/or chromosomal CNGs were identified in approximately 25% of evaluable cases. These alterations were enriched in right-sided CRCs and in older patients, suggesting a link with age-related genomic instability. Polyploid/CNG tumors did not show significant enrichment for canonical CRC driver mutations (RAS, TP53, SMAD4), although trends toward co-occurrence with BRAF mutation and mutual exclusivity with HER2 amplification were observed. Integrative bioinformatic analyses highlighted dysregulation of pathways involved in mitotic control, centrosome organization, and DNA replication stress. Conclusions: In metastatic colon cancer, the presence of genome-wide copy number gain may delineate a tumor subset with distinctive clinicopathological and molecular characteristics. Further studies are warranted to elucidate the biological significance of these features and to explore their potential implications for tumor evolution, treatment response, and clinical stratification. Full article
(This article belongs to the Special Issue Innovations in Colorectal Cancer)
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