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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition

edited by

Serafeim Chrysovalantis Kotoulas

, Dionisios G. Spyratos and

Athanasia Pataka

submission deadline 15 Nov 2025 | Viewed by 142 | Submission Open

Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancer Treatment: Present and Future of Radioligand Therapy

edited by

Egesta Lopci

and

Akram N. Al-Ibraheem

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3019 | Submission Open

Keywords: radioligand therapy; PRLT; FAPI; PSMA; CXCR4; GRPR; GLP-1R; RLT; novel radiopharmaceutical; cancer theranostics

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer: New Advances from Diagnosis to Therapy: 2nd Edition

edited by

Michael Kreißl

submission deadline 20 Nov 2025 | 4 articles | Viewed by 2576 | Submission Open

Keywords: thyroid scintigraphy; thyroid nodules; thyroid cancer; multikinase inhibitors; precision oncology; radioiodine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Advances in the Treatment of Pediatric Solid Tumors

edited by

Myriam Weyl Ben-Arush

and Oz Mordechai

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2500 | Submission Open

Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies

(This special issue belongs to the Section Pediatric Oncology)

Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders

edited by

Alister C. Ward

submission deadline 20 Nov 2025 | Viewed by 413 | Submission Open

Keywords: cytokine receptor; signaling; leukemia; lymphoma; myeloproliferative neoplasm; hematology; oncology

(This special issue belongs to the Section Tumor Microenvironment)

Targeting the Vulnerabilities of Oncogene Activation (Second Edition)

edited by

Jack L. Arbiser

submission deadline 20 Nov 2025 | Viewed by 174 | Submission Open

Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target

(This special issue belongs to the Section Methods and Technologies Development)

Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)

edited by Nuria Romero-Laorden

submission deadline 20 Nov 2025 | Viewed by 127 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Salivary and Tissue Biomarkers in Head and Neck Cancers: Diagnostic and Prognostic Role

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Nov 2025 | Viewed by 126 | Submission Open

Keywords: head and neck cancer; biomarker; early diagnosis and prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Improving the Quality of Life in Patients with Gynecological Cancer

edited by Vasilios Pergialiotis

submission deadline 20 Nov 2025 | Viewed by 59 | Submission Open

Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 21 Nov 2025 | 1 articles | Viewed by 1326 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 23 Nov 2025 | 1 articles | Viewed by 748 | Submission Open

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)

edited by

Shihori Tanabe

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1062 | Submission Open

Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 25 Nov 2025 | Viewed by 238 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials of Sarcoma

edited by Patrick Schlegel

submission deadline 25 Nov 2025 | Viewed by 157 | Submission Open

Keywords: cancer; sarcoma; clinical trial

Neurosurgical Advances in Brain Tumor Surgery

edited by Camilla Bonaudo, Alessandro Della Puppa and

Antonello Grippo

submission deadline 28 Nov 2025 | 1 articles | Viewed by 1648 | Submission Open

Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Brachytherapy in the Treatment of Tumors

edited by

Hideya Yamazaki

submission deadline 30 Nov 2025 | 10 articles | Viewed by 26346 | Submission Open

Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Approaches for Cancer Treatment

edited by

Marzia Bruna Gariboldi

submission deadline 30 Nov 2025 | 10 articles | Viewed by 18224 | Submission Open

Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy in the Management of Hematologic Malignancy

edited by Mohammad S. Hossain

submission deadline 30 Nov 2025 | 6 articles | Viewed by 17320 | Submission Open

Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Radiomics and Imaging in Cancer Analysis

edited by

Marco Bertolini

and

Lidia Strigari

submission deadline 30 Nov 2025 | 7 articles | Viewed by 15619 | Submission Open

Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Immunotherapy in Clinical and Translational Research

edited by Sofia Genta

submission deadline 30 Nov 2025 | 6 articles | Viewed by 15409 | Submission Open

Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 30 Nov 2025 | 2 articles | Viewed by 13053 | Submission Open

Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system

(This special issue belongs to the Section Cancer Therapy)

Sarcoma: Clinical Trials and Management

edited by

Mohammed M. Milhem

and

John Rieth

submission deadline 30 Nov 2025 | 6 articles | Viewed by 8621 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma

(This special issue belongs to the Section Clinical Research of Cancer)

The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives

edited by

Debora Capelli

submission deadline 30 Nov 2025 | 2 articles | Viewed by 7877 | Submission Open

Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Esophagogastric Cancer

edited by

B.P.L. (Bas) Wijnhoven

Richard Skipworth

, Pieter Van der Sluis and

Tania Triantafyllou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7711 | Submission Open

Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Advancements in Surgical Approaches for Gynecological Cancers

edited by

Anna Myriam Perrone

and

Camelia Alexandra Coada

submission deadline 30 Nov 2025 | 6 articles | Viewed by 6705 | Submission Open

Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins

(This special issue belongs to the Section Cancer Therapy)

Immune Landscape of Renal Cell Carcinoma

edited by

Scott S. Tykodi

and Yuexin Xu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5648 | Submission Open

Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | 5 articles | Viewed by 5151 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Solid Cancers: Current and Future Landscape

edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4225 | Submission Open

Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell

(This special issue belongs to the Section Cancer Therapy)

Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3754 | Submission Open

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

Novel Advances in Surgery for Prostate Cancer

edited by

Vincenzo De Marco

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3677 | Submission Open

Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging

edited by Andra Valentina Krauze

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3632 | Submission Open

Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations

(This special issue belongs to the Section Methods and Technologies Development)

Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer

edited by

Giovanni Crisafulli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3236 | Submission Open

Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach

(This special issue belongs to the Section Methods and Technologies Development)

Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis: 2nd Edition

edited by

Carl-Henrik Heldin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2774 | Submission Open

Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis

(This special issue belongs to the Section Molecular Cancer Biology)

Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)

edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1727 | Submission Open

Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1681 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Tissue-Agnostic Drug Development in Cancer (2nd Edition)

edited by Shivaani Kummar and

Kyaw Thein

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1672 | Submission Open

Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine

(This special issue belongs to the Section Cancer Drug Development)

Advances in the Surgical Treatment of Spinal Tumors

edited by Daniel Lubelski

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1513 | Submission Open

Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life

(This special issue belongs to the Section Cancer Therapy)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1432 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Castration-Resistant Prostate Cancer Treatment

edited by

Eswar Shankar

and

Balaji Chandrasekaran

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1402 | Submission Open

Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination

(This special issue belongs to the Section Cancer Therapy)

Calcium Signaling in Cancer Cell Progression

edited by

Amantini Consuelo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1191 | Submission Open

Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Tumor Microenvironment in Primary Liver Cancer 2nd edition

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 30 Nov 2025 | 1 articles | Viewed by 863 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

Surgery in Metastatic Cancer (2nd Edition)

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2025 | 1 articles | Viewed by 823 | Submission Open

Keywords: metastatic cancer; surgery; metastasectomy; indication; timing

(This special issue belongs to the Section Cancer Therapy)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Nov 2025 | 1 articles | Viewed by 685 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 30 Nov 2025 | 1 articles | Viewed by 653 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice

edited by Xiaotong Song

submission deadline 30 Nov 2025 | 1 articles | Viewed by 593 | Submission Open

Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in the Molecular Genetics of Sarcomas

edited by Wei Jiang

submission deadline 30 Nov 2025 | Viewed by 431 | Submission Open

Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification

(This special issue belongs to the Section Molecular Cancer Biology)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 30 Nov 2025 | Viewed by 387 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research of Cancer)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by Cesare Guida and Ida D'Onofrio

submission deadline 30 Nov 2025 | 1 articles | Viewed by 385 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Mesothelioma: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 30 Nov 2025 | Viewed by 286 | Submission Open

Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy

(This special issue belongs to the Section Cancer Therapy)

Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions

edited by Yongwoo Dave Seo

submission deadline 30 Nov 2025 | Viewed by 270 | Submission Open

Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 401-450 on page 9 of 23.

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