Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 10
Special Issue Editor
Interests: breast cancer; GU cancers; GYN cancers; metronomic chemotherapy; targeted therapies; combination strategies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The therapeutic landscape of breast cancer is undergoing a profound transformation driven by the integration of multimodal strategies that combine classical cytotoxic chemotherapy with endocrine treatment, radiotherapy, monoclonal antibodies, antibody–drug conjugates, small-molecule kinase inhibitors, metronomic chemotherapy, and emerging immunotherapies. These rational combination approaches offer the potential to enhance antitumor efficacy, delay or overcome intrinsic and acquired resistance, optimize long-term disease control, and improve survival across both early-stage and metastatic settings. Endocrine-based combinations, HER2-directed doublet and triplet strategies, ADC-containing regimens, and synergistic pairings of targeted agents with immunotherapy or radiotherapy illustrate the growing complexity and promise of modern breast cancer treatment. Despite this progress, many questions remain regarding optimal sequencing, patient selection, toxicity mitigation, and biomarker-guided personalization. This Special Issue aims to highlight the latest advances in chemoradiation, endocrine combinations, molecularly targeted therapies, metronomic chemotherapy, and innovative multi-agent strategies. We welcome original research papers and comprehensive reviews that elucidate underlying biological mechanisms, identify predictive and prognostic biomarkers, explore real-world evidence, and refine therapeutic algorithms to advance precision care for patients with breast cancer.
Prof. Dr. Piotr J. Wysocki
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- combination therapy
- endocrine therapy
- chemoradiation
- monoclonal antibodies
- antibody–drug conjugates (ADCs)
- small-molecule kinase inhibitors
- immunotherapy
- predictive biomarkers
- therapy resistance
- precision oncology
- translational research
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