Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 44

Special Issue Editors


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Guest Editor
First Department of Internal Medicine, Democritus University of Thrace, Komotini, Greece
Interests: hematopoietic stem cells; hematopoietic stem cell niche; myelopoiesis; neutrophils; neutrophil extracellular traps; thrombosis; myelodysplastic syndrome
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Guest Editor
Department of Hematology, Democritus University of Thrace, Alexandroupolis, Greece
Interests: myelodysplastic syndrome; hematopoietic stem cell transplantation
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Guest Editor
Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: hematologic malignancies; thrombosis; complement; cellular therapy; lymphoma; myeloma; COVID-19
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Special Issue Information

Dear Colleagues,  

Over recent decades, significant progress has been made in the molecular characterization of myeloid malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPNs). Technological progress has made the identification of several driver mutations feasible, paving the way for a personalized approach to the diagnosis and treatment of these disorders, as well as the introduction of targeted therapies in clinical practice. 

Despite fundamental discoveries having helped decipher the genetic basis of myeloid malignancies and the interaction between clonal cells and the bone marrow micro-environment, the treatment of this disorder has remained largely unchanged. For instance, the treatment of patients with low-risk MDS is still largely supportive, using growth factors and transfusions to improve the symptoms of the disease, whereas hypomethylating agents are used in the treatment of older patients with advanced MDS and AML. Based on the aging of the population, the prevalence of these disorders is expected to increase in the coming years. 

This Special Issue is a continuation of our previous Issue, “Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia”. (https://www.mdpi.com/journal/cancers/special_issues/MDS_AML)

Our aim in launching this Special Issue is to discuss recent findings relating to the epidemiology, treatment, and pathogenesis of MDS and AML. Epidemiological studies, clinical trials involving the introduction of novel treatment strategies for MDS and AML, original translational research articles, and reviews are welcome in this Special Issue.

We look forward to receiving your contributions.

Dr. Ioannis Mitroulis
Dr. Konstantinos Liapis
Dr. Eleni Gavriilaki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • myelodysplastic syndrome
  • acute myeloid leukemia
  • bone marrow micro-environment
  • targeted therapies
  • hematopoietic stem cell
  • leukemic stem cell
  • hematopoietic stem cell transplantation

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Published Papers

This special issue is now open for submission.
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