Detection of Breast Cancer with Mammography

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 15 April 2026 | Viewed by 1247

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are excited to announce the call for submissions to a Special Issue of Cancers focusing on the topic of "Detection of Breast Cancer with Mammography". Mammography remains one of the most widely used imaging techniques for the early detection of breast cancer. This Special Issue aims to explore the latest advancements, challenges, and opportunities in the field of mammographic screening for breast cancer.

We invite researchers and clinicians to submit original research articles and reviews that cover various aspects of mammography in breast cancer detection, including, but not limited to, the following:

  1. Novel imaging technologies and techniques in mammography;
  2. Computer-aided detection and artificial intelligence in mammography;
  3. The optimization of mammographic screening protocols;
  4. Evaluating the effectiveness and limitations of mammography;
  5. Radiomics and machine learning in mammographic interpretation;
  6. Patient experience and adherence to mammographic screening.

All submitted articles will undergo a rigorous peer review process to ensure the highest scientific quality and relevance to this field. We encourage contributions from experts in the fields of breast cancer research, radiology, and oncology.

By consolidating the latest research findings and clinical experiences, we aim to enhance the accuracy, efficiency, and accessibility of breast cancer detection with mammography. We believe that your valuable contributions will significantly contribute to the success of this Special Issue.

Should you have any questions, require further information, or need any assistance, please do not hesitate to reach out to us. We are here to support and facilitate your participation in this Special Issue.

Thank you for your attention to this matter, and we look forward to receiving your valuable submissions.

Dr. Luca Nicosia
Guest Editor

Manuscript Submission Information

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Keywords

  • mammography
  • breast cancer detection
  • imaging technologies
  • artificial intelligence
  • radiomics

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Published Papers (1 paper)

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Research

12 pages, 1742 KiB  
Article
Influence of Breast Density and Menopausal Status on Background Parenchymal Enhancement in Contrast-Enhanced Mammography: Insights from a Retrospective Analysis
by Luca Nicosia, Luciano Mariano, Carmen Mallardi, Adriana Sorce, Samuele Frassoni, Vincenzo Bagnardi, Cristian Gialain, Filippo Pesapane, Claudia Sangalli and Enrico Cassano
Cancers 2025, 17(1), 11; https://doi.org/10.3390/cancers17010011 - 24 Dec 2024
Viewed by 773
Abstract
Background: Contrast-enhanced mammography (CEM) has recently gained recognition as an effective alternative to breast magnetic resonance imaging (MRI) for assessing breast lesions, offering both morphological and functional imaging capabilities. However, the phenomenon of background parenchymal enhancement (BPE) remains a critical consideration, as it [...] Read more.
Background: Contrast-enhanced mammography (CEM) has recently gained recognition as an effective alternative to breast magnetic resonance imaging (MRI) for assessing breast lesions, offering both morphological and functional imaging capabilities. However, the phenomenon of background parenchymal enhancement (BPE) remains a critical consideration, as it can affect the interpretation of images by obscuring or mimicking lesions. While the impact of BPE has been well-documented in MRI, limited data are available regarding the factors influencing BPE in CEM and its relationship with breast cancer (BC) characteristics. Materials: This retrospective study included 116 patients with confirmed invasive BC who underwent CEM prior to biopsy and surgery. Data collected included patient age, breast density, receptor status, tumor grading, and the Ki-67 proliferation index. BPE was evaluated by two radiologists using the 2022 ACR BI-RADS lexicon for CEM. Statistical analyses were conducted to assess the relationship between BPE, patient demographics, and tumor characteristics. Results: The study found a significant association between higher levels of BPE and specific patient characteristics. In particular, increased BPE was more commonly observed in patients with higher breast density (p < 0.001) and those who were pre-menopausal (p = 0.029). Among patients categorized under density level B, the majority exhibited minimal BPE, while those in categories C and D showed progressively higher levels of BPE, indicating a clear trend correlating higher breast density with increased enhancement. Additionally, pre-menopausal patients demonstrated a higher likelihood of moderate to marked BPE compared to post-menopausal patients. Despite these significant associations, the analysis did not reveal a meaningful correlation between BPE intensity and tumor subtypes (p = 0.77) or tumor grade (p = 0.73). The inter-reader agreement for BPE assessment was substantial, as indicated by a weighted kappa of 0.78 (95% CI: 0.68–0.89), demonstrating consistent evaluation between radiologists. Conclusions: These findings suggest that BPE in CEM is influenced by factors like breast density and age, aligning with patterns observed in MRI studies. However, BPE intensity was not associated with tumor subtypes or grades, indicating a poorer prognosis. These insights highlight the potential of BPE as a risk biomarker in preventive follow-up, particularly for patients with high breast density and pre-menopausal status. Further multicentric and prospective studies are needed to validate these results and deepen the understanding of BPE’s role in CEM diagnostics. Full article
(This article belongs to the Special Issue Detection of Breast Cancer with Mammography)
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