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The Role of Regulatory Non-Coding RNA in Cancer (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (4 April 2026) | Viewed by 861

Special Issue Editors


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Guest Editor
Tumor Biology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA
Interests: tumor biology; melanoma; skin cancers; photobiology; photochemistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Tumor Biology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA
Interests: melanoma; melanin-biochemistry; skin pigmentation; melanin-chemiexcitation; human genetics; environmental carcinogenicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although initially presumed to be non-functional, numerous studies from the past decade have established the indispensable functions of non-coding RNAs (ncRNAs), including in chromatin remodeling and transcriptional as well as post-transcriptional regulation. In cancer, ncRNAs have been implicated in events of initiation and progression. These include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNAs, small nucleolar RNAs (snoRNAs), and sno-derived RNAs. Most of the literature discusses the involvement of miRNAs, siRNAs, and lncRNAs in different cancers, but other ncRNA types are also supposed to have significant contributions to carcinogenesis.

Since ncRNAs are critical in cancer development and metastasis, this Special Issue will not only describe novel ncRNAs but also the unexplored mechanisms by which these ncRNAs regulate distinct aspects of carcinogenesis. It will also focus on the therapeutic targeting of these ncRNAs to develop and optimize anticancer strategies. Moreover, whether specific ncRNAs have tissue-and/or cancer-type-specific roles and regulation will also be discussed in this Special Issue.

Dr. Jyoti Srivastava
Dr. Sanjay Premi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer initiation
  • cancer progression
  • metastasis
  • ncRNAs
  • miRNAs
  • lncRNAs
  • gene regulation
  • chromatin remodeling
  • targeted therapeutics

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Published Papers (1 paper)

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Research

18 pages, 7544 KB  
Article
m6A RNA Methylation Promotes the Melanoma Metastasis Mediated by Extracellular Vesicle miR-23a-5p
by Chenshi Li, Jie Li, Xue Han, Yuting Chen, Lei Shi, Meng Xiang, Yuhan Zhang, Yan Chen, Bowen Li, Yao Tang, Jiyu Tan, Jiacheng Xie, H. Rosie Xing, Jianyu Wang, Mo Chen and Guoning Huang
Cancers 2026, 18(5), 792; https://doi.org/10.3390/cancers18050792 - 28 Feb 2026
Viewed by 566
Abstract
Background/Objectives: Melanoma, characterized by high rates of metastasis and recurrence, is a particularly aggressive malignant tumor. The underlying mechanisms driving its progression remain enigmatic. The close interplay between tumor and non-tumor cells is pivotal, significantly shaping the tumor microenvironment. Extracellular vesicles emerge [...] Read more.
Background/Objectives: Melanoma, characterized by high rates of metastasis and recurrence, is a particularly aggressive malignant tumor. The underlying mechanisms driving its progression remain enigmatic. The close interplay between tumor and non-tumor cells is pivotal, significantly shaping the tumor microenvironment. Extracellular vesicles emerge as a crucial vector influencing this environment, as they can modulate cellular mechanisms and biological functions—marking a key frontier in tumor mechanism research. However, the potential impact of intercellular communication on tumor cell biology remains largely unexplored. Methods: In the study, we employed a pair of cell lines derived from melanoma M14 cells, designated as highly metastatic cells (POL cells) and the low metastatic cells (OL cells), and elucidate their characteristics. Results: Our findings revealed that POL cells can potentiate the metastatic potential of OL cells through the transfer of extracellular vesicles, which harbor functional microRNAs, specifically miR-23a-5p in this context. Upon entering OL cells, the EV-miR-23a-5p orchestrates changes in the m6A modification levels of the mRNA of tumor suppressor genes Mtus1 and Prrg4. Conclusions: This modulation subsequently influences the expression of these genes and, in turn, the invasive behavior of OL cells. Full article
(This article belongs to the Special Issue The Role of Regulatory Non-Coding RNA in Cancer (2nd Edition))
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