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Cancers
Special Issues
Colorectal Cancer Liver Metastases
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Colorectal Cancer Liver Metastases

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 548

Special Issue Editors

Dr. Piero Boraschi

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Guest Editor
2nd Unit of Radiology, Department of Radiological Nuclear and Laboratory Medicine, Pisa University Hospital, Via Paradisa 2, Pisa 56124, Italy
Interests: abdominal radiology; MRI; diffusion and perfusion MRI; oncologic imaging; liver; pancreas; biliary tract; rectal cancer; inflammatory bowel disease; liver transplantation
Special Issues, Collections and Topics in MDPI journals
Dr. Francescamaria Donati

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Guest Editor
Department of Diagnostic and Interventional Radiology, and Nuclear Medicine, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
Interests: abdominal radiology; MR imaging; diffusion and perfusion MR imaging; oncologic imaging; liver; pancreas; biliary tract; rectal cancer; inflammatory bowel disease; liver transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Liver metastases are a critical complication in colorectal cancer (CRC), significantly impacting patient survival and quality of life. Despite extensive research, challenges remain in understanding the underlying molecular mechanisms and improving the treatment outcomes for patients with CRC liver metastases. This Special Issue highlights the latest advancements in research, focusing on the biological processes, genetic alterations, and immune evasion strategies that drive the metastatic spread to the liver. Additionally, it discusses innovative diagnostic techniques, such as liquid biopsy and advanced imaging, which are crucial for early detection and monitoring disease progression. Therapeutic strategies, including surgical resection, liver-directed therapies, chemotherapy, targeted treatments, and immunotherapy, are examined for their clinical applicability and effectiveness. However, the Special Issue also underscores the major challenges, such as tumor heterogeneity, therapy resistance, and the need for personalized treatment approaches. The aim of this Special Issue is to provide a comprehensive review of the state-of-the-art research on CRC liver metastases, address current challenges, and propose future directions to optimize clinical management and improve patient outcomes.

Dr. Piero Boraschi
Dr. Francescamaria Donati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver metastases
  • colorectal cancer
  • treatment
  • imaging
  • oncologic strategy

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Published Papers (1 paper)

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Research

16 pages, 1965 KiB  
Article
Establishment of an Orthotopic and Metastatic Colorectal Cancer Mouse Model Using a Tissue Adhesive-Based Implantation Method
by Sang Bong Lee, Hui-Jeon Jeon, Hoon Hyun and Yong Hyun Jeon
Cancers 2025, 17(13), 2266; https://doi.org/10.3390/cancers17132266 - 7 Jul 2025
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Abstract
Background: To overcome the limitations of conventional CRC (colorectal cancer) mouse models in replicating metastasis and enabling efficient therapeutic evaluation, we developed a novel implantation method using tissue adhesive to establish reproducible orthotopic and metastatic tumors. Conventional models using injection or suturing techniques [...] Read more.
Background: To overcome the limitations of conventional CRC (colorectal cancer) mouse models in replicating metastasis and enabling efficient therapeutic evaluation, we developed a novel implantation method using tissue adhesive to establish reproducible orthotopic and metastatic tumors. Conventional models using injection or suturing techniques often suffer from technical complexity, inconsistent tumor establishment, and limited metastatic reliability. Methods: We developed and validated a novel orthotopic and metastatic CRC model utilizing tissue adhesive for tumor transplantation. Uniform tumor fragments derived from bioluminescent HCT116/Luc xenografts were affixed to the cecum of nude mice. Tumor growth and metastasis were monitored through bioluminescence imaging and confirmed by the results of histological analysis of metastatic lesions. The model’s utility for therapeutic testing was evaluated using MK801, an NMDA receptor antagonist. Results: The biological-based model demonstrated rapid and reproducible tumor implantation (<5 min), consistent primary tumor growth, and robust metastasis to the liver and lungs. The biological-based approach achieved 80% tumor engraftment (4/5), with consistent metastasis to the liver and lungs in all mice, compared with lower and variable metastasis rates in injection (0%, 0/5) and suturing (20%, 1/5) methods. MK801 treatment significantly suppressed both primary tumor growth and metastasis, validating the model’s suitability for preclinical drug evaluation. Conclusions: By enabling rapid, reproducible, and spontaneous formation of metastatic lesions using a minimally invasive tissue adhesive technique, our model represents a significant methodological advancement that supports high-throughput therapeutic screening and bridges the gap between experimental modeling and clinical relevance in colorectal cancer research. Full article
(This article belongs to the Special Issue Colorectal Cancer Liver Metastases)
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