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Cancers, Volume 17, Issue 12

June-2 2025 - 162 articles

Cover Story: Radiotherapy has long been a cornerstone of cancer treatment; however, recent technological and biological advances are rapidly transforming its practice. In this review, we highlight key innovations—including adaptive radiotherapy, advanced imaging, artificial intelligence, proton and FLASH therapy, brachytherapy, theranostics, and radioimmunotherapy—that are redefining precision, personalization, and effectiveness in cancer care. By summarizing both emerging technologies and evolving clinical strategies, this work offers a comprehensive overview of the most promising directions shaping the future of radiation oncology. View this paper
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Articles (162)

  • Article
  • Open Access
1 Citations
1,252 Views
16 Pages

19 June 2025

Objectives: Mesothelin (MSLN) is overexpressed in pancreatic ductal adenocarcinoma (PDAC), promoting cell proliferation, migration, and inhibiting apoptosis. While its oncogenic properties have been documented, the role of MSLN in regulating cellular...

  • Article
  • Open Access
745 Views
12 Pages

Prognostic Biopsy of Choroidal Melanoma Before and After Ruthenium-106 Plaque Brachytherapy: Impact on Success of Cytogenetic Analysis

  • Keri McLean,
  • Helen Kalirai,
  • Muhammad H. Amer,
  • Bertil Damato,
  • Sarah E. Coupland,
  • Heinrich Heimann and
  • Rumana N. Hussain

19 June 2025

Background/Objectives: To determine if the results of cytogenetic analyses of choroidal melanoma biopsies after ruthenium-106 plaque brachytherapy (RPB) are affected by this procedure. Methods: A retrospective study was conducted on 368 patients with...

  • Article
  • Open Access
955 Views
23 Pages

Impact of Chemotherapy on Implant-Based Breast Reconstruction in Breast Cancer Patients: A Nationwide, Retrospective, Cohort Study

  • Jin Ah Lee,
  • Hye Sun Lee,
  • Soyoung Jeon,
  • Dooreh Kim,
  • Young Joo Lee,
  • Soo Youn Bae,
  • Woo-Chan Park,
  • Chang Ik Yoon and
  • Jangyoun Choi

19 June 2025

Background: Implant-based breast reconstruction (IBBR) is a widely adopted technique following mastectomy in breast cancer patients. However, the impact of chemotherapy type and duration on the development of capsular contracture remains unclear. Met...

  • Article
  • Open Access
1,907 Views
14 Pages

High-Risk Early-Stage Endometrial Cancer: Role of Adjuvant Therapy and Prognostic Factors Affecting Survival

  • Ji Hyun Hong,
  • Jun Kang,
  • Sung Jong Lee,
  • Keun Ho Lee,
  • Soo Young Hur and
  • Yeon-Sil Kim

19 June 2025

Background/Objectives: High-grade endometrial cancer, including non-endometrioid and grade 3 endometrioid histologies, is associated with poor prognosis despite early-stage diagnosis. This study assessed the prognosis of early-stage high-grade endome...

  • Review
  • Open Access
1,216 Views
23 Pages

Current Perspectives on Mesenchymal Dendritic Cell Neoplasms of Lymphoid Tissue: Insights into Ontogeny, Updates on Classification, and Clinicopathologic Characteristics

  • Neha Seth,
  • Jithma P. Abeykoon,
  • Gaurav Goyal,
  • Ronald S. Go,
  • Steven Tessier,
  • Rebecca L. King and
  • Aishwarya Ravindran

19 June 2025

Mesenchymal dendritic cell neoplasms represent a distinct category of hematologic malignancies that challenge traditional classifications of histiocytic and classical dendritic/Langerhans cell neoplasms. Historically grouped under the broader umbrell...

  • Article
  • Open Access
717 Views
10 Pages

Atrial Fibrillation Risk in Relation to the Clinical Staging of Gastric Cancer: A Nationwide Population-Based Cohort Study

  • Mi Jin Oh,
  • Yoon Jin Choi,
  • Jin-Hyung Jung,
  • Seunghan Lee,
  • Kyungdo Han and
  • Soo-Jeong Cho

19 June 2025

Background/Objectives: Patients with gastric cancer (GC) have an elevated risk of atrial fibrillation (AF) and cardiovascular mortality, compared with the general population. However, the effect of the cancer stage on the development of AF remains un...

  • Article
  • Open Access
956 Views
26 Pages

Prospective Evaluation of the Influence of Chemoradiotherapy and Stoma on Functional and Symptomatic Outcomes in Rectal Cancer Patients

  • Michael Schenker,
  • Luiza Cristiana Bițînă,
  • Ramona Adriana Schenker,
  • Ana-Maria Ciurea,
  • Alina Maria Mehedințeanu,
  • Tradian Ciprian Berisha,
  • Lucian Dragoș Bratu,
  • Monica Laura Cara,
  • Andrei Mircea Dicianu and
  • Puiu Olivian Stovicek

19 June 2025

Background and Objectives: Rectal cancer is a major cause of morbidity and mortality worldwide, and although current therapeutic protocols have improved survival, treatment-related toxicities may significantly affect patients’ daily functioning...

  • Article
  • Open Access
682 Views
15 Pages

Counties with Low Employment and Education Status Are Associated with Higher Age-Adjusted Cancer Mortality

  • Minu Ponnamma Mohan,
  • Joel B. Epstein,
  • Kapil S. Meleveedu,
  • Roberto Pili and
  • Poolakkad S. Satheeshkumar

19 June 2025

Background: This study aims to evaluate the potential relationship between county-level social determinants of health (SDOH)—specifically education and job status—and cancer mortality. Methods: We utilized Social Determinants of Health (S...

  • Article
  • Open Access
1,274 Views
12 Pages

Automated Clinical Dosimetry Planning of Dense Lattice Radiation Therapy

  • David Macias-Verde,
  • Javier Burgos-Burgos and
  • Pedro C. Lara

19 June 2025

Background: Patients bearing large-volume, bulky primary or relapsed tumors, are usually referred to palliative low-dose radiotherapy with very poor results. Lattice Radiation Therapy (LRT) is able to produce a high number of high-dose foci or vortex...

  • Review
  • Open Access
1,347 Views
31 Pages

19 June 2025

Ionizing radiation (IR) poses a dual challenge in medicine; while essential for cancer therapy, it inflicts collateral damage to normal tissues, particularly the gastrointestinal (GI) tract. High-dose IR triggers acute radiation syndrome (ARS), chara...

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Cancers - ISSN 2072-6694Creative Common CC BY license