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Cancers
Special Issues
Surgical Treatment of Hepato-Pancreato-Biliary Cancers
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Surgical Treatment of Hepato-Pancreato-Biliary Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 27 April 2026 | Viewed by 386

Special Issue Editor

Dr. Mariano C. Giglio

E-Mail Website
Guest Editor
Division of Minimally Invasive and Robotic HPB Surgery and Transplantation Service, Federico II University Hospital, Naples, Italy
Interests: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers

Special Issue Information

Dear Colleagues,

Surgical treatment remains a cornerstone in the management of hepato-pancreato-biliary cancers.  Advances in surgical techniques, the integration of multimodal treatment strategies, and improvements in perioperative care have significantly reshaped therapeutic decision-making for many patients.  This Special Issue will explore current challenges and recent developments in the surgical management—whether as a standalone treatment or integrated into multimodal approaches—of HPB malignancies.  Original research and review articles addressing surgical indications, patient selection, technical innovations, and outcomes in the evolving landscape of HPB oncology are welcome. Contributions highlighting the role of surgery within multidisciplinary frameworks and the integration of emerging systemic or locoregional therapies are also particularly encouraged.

Dr. Mariano C. Giglio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatic cancer
  • hepatocellular carcinoma
  • colorectal liver metastases
  • liver surgery
  • pancreatic surgery
  • hepato-biliary cancers

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Published Papers (1 paper)

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Research

11 pages, 369 KiB  
Article
Robotic Versus Open Pancreaticoduodenectomy: A Single-Center Analysis of Safety and Efficacy Using Inverse Probability of Treatment Weighting
by Mariano Cesare Giglio, Silvia Campanile, Gianluca Rompianesi, Giuseppe Loiaco, Riccardo Aurelio Nasto, Roberto Montalti and Roberto Ivan Troisi
Cancers 2025, 17(12), 1916; https://doi.org/10.3390/cancers17121916 - 9 Jun 2025
Viewed by 319
Abstract
Background/Objectives: Robotic surgery has emerged as a promising alternative to traditional approaches, offering enhanced precision and ergonomics. However, its application to pancreaticoduodenectomy (PD) remains controversial due to technical complexity and a steep learning curve. This study aims to evaluate the perioperative outcomes of [...] Read more.
Background/Objectives: Robotic surgery has emerged as a promising alternative to traditional approaches, offering enhanced precision and ergonomics. However, its application to pancreaticoduodenectomy (PD) remains controversial due to technical complexity and a steep learning curve. This study aims to evaluate the perioperative outcomes of robotic versus open PD at a single high-volume center, using inverse probability of treatment weighting (IPTW) to control for confounding variables. Methods: A retrospective, single-center analysis was conducted on patients who underwent PD between January 2020 and December 2024. Perioperative and oncological outcomes were compared using IPTW, aiming to balance potential confounding variables. The primary endpoint was 90-day postoperative mortality; secondary endpoints included operative time, estimated blood loss, major postoperative complications (Clavien-Dindo grade ≥ IIIa), and length of hospital stay. Results: Seventy-four patients were included in the intention-to-treat analysis (open: n = 31; robotic: n = 43). After IPTW adjustment, baseline characteristics were balanced across the groups. Operative time was significantly longer in the robotic group (median 540 vs. 479 min, p = 0.009). No significant differences were observed in 90-day mortality (4.9% both groups, p = 0.998), postoperative complications ≥ IIIa, or histopathological outcomes, including R0 resection and lymph node yield. Trends toward reduced estimated blood loss and shorter hospital stay in the robotic group did not reach statistical significance. Conclusions: Robotic pancreaticoduodenectomy demonstrates comparable safety and oncological efficacy to the open approach, with longer operative times but potential perioperative advantages. These findings support the continued integration of robotic techniques even in medium-volume centers with appropriate expertise. Full article
(This article belongs to the Special Issue Surgical Treatment of Hepato-Pancreato-Biliary Cancers)
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