cancers-logo

Journal Browser

Journal Browser

Screening and Surveillance of Gastrointestinal and Pancreatic Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1413

Special Issue Editors


E-Mail Website
Guest Editor
The Royal Marsden NHS Foundation Trust, London, UK
Interests: gastrointestinal cancer; endoscopy; pancreatic cancer

E-Mail Website
Guest Editor
1. Institute of Gastrointestinal Oncology, Military University Hospital Prague, Prague, Czech Republic
2. Department of Medicine, First Faculty of Medicine, Charles University, Prague and Military University Hospital Prague, Prague, Czech Republic
3. Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
Interests: colorectal cancer; gastroenterology; gastric cancer; pancreatic cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Screening in average- and high-risk populations has become one of the most important cornerstones in current gastroenterology practice. Recommendations and guidelines for the subsequent surveillance of individuals who have been diagnosed with a GI/pancreatic precancerous condition have been developed.

The aim of high-quality screening and surveillance is clear: to enable an early intervention (either by endoscopy or other means) to allow the best possible outcome for the patient.

Our Special Issue is focused on screening in average- and high-risk populations and on appropriate surveillance.

We especially welcome the following types of papers:

  • Randomised controlled trials;
  • Prospective studies;
  • Review articles supported by the most recent literature.

We would appreciate if gastroenterologists involved in screening programmes contributed to this Special Issue.

Potential topics of interest include, but are not limited to, the following:

  • Oesophageal neoplasia—current screening and surveillance of Barrett’s oesophagus;
  • Gastric neoplasia—screening and surveillance of high-risk populations;
  • Coeliac disease—screening and surveillance;
  • Small bowel polyposis—screening and surveillance;
  • Pancreatic precancerous lesions—surveillance;
  • Colorectal neoplasia—screening in average- and high-risk populations and surveillance.

Prof. Dr. Darina Kohoutová
Prof. Dr. Jan Bures
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • screening
  • surveillance
  • GI cancer
  • pancreatic precancerous lesions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

17 pages, 631 KB  
Review
Genetic Predisposition to Pancreatic Cancer: A Systematic Review of Hereditary Syndromes and Familial Aggregation
by Catalin Sergiu Baraian, Claudiu Stefan Turculet and Ionut Negoi
Cancers 2026, 18(6), 976; https://doi.org/10.3390/cancers18060976 - 18 Mar 2026
Viewed by 1030
Abstract
Background: Pancreatic cancer is a highly lethal malignancy, with a 5-year survival rate of approximately 8%. Roughly 10% of cases occur in individuals with familial pancreatic cancer or identified high-risk germline mutations, including STK11, CDKN2A, BRCA1/2, MLH1, and MSH2. Aim: We aimed to [...] Read more.
Background: Pancreatic cancer is a highly lethal malignancy, with a 5-year survival rate of approximately 8%. Roughly 10% of cases occur in individuals with familial pancreatic cancer or identified high-risk germline mutations, including STK11, CDKN2A, BRCA1/2, MLH1, and MSH2. Aim: We aimed to evaluate the risk of pancreatic cancer associated with inherited genetic mutations and to characterize these genetic syndromes. Methods: A systematic search of the PubMed database up to 2024 identified 1500 articles, of which 90 met the criteria for inclusion in this review. Results: High-risk individuals were defined as those with at least a 10-fold increased risk, moderate risk as 5–10-fold and low risk as under 5-fold. High-risk individuals included those with Peutz–Jeghers syndrome (132–140-fold risk), hereditary pancreatitis (50–87-fold risk), Familial Atypical Multiple Mole Melanoma syndrome (up to 48-fold risk), hereditary breast and ovarian cancer with BRCA2 mutation (up to 22-fold risk), and familial pancreatic cancer with at least three affected relatives (up to 32-fold risk). Moderate-risk patients had BRCA1, MLH1, MSH2, MSH6, p53, and ATM mutations, as well as familial pancreatic cancer with 1–2 affected kindred. Low-risk patients had familial adenomatous polyposis. Conclusions: Identifying high-risk individuals is crucial for effective genetic counseling, testing, and potential screening programs to facilitate early diagnosis and improve outcomes. Future research should prioritize large prospective cohorts, screening programs, and the integration of emerging technologies, such as AI-assisted imaging. Full article
(This article belongs to the Special Issue Screening and Surveillance of Gastrointestinal and Pancreatic Cancers)
Show Figures

Figure 1

Back to TopTop