Cancer Cell Motility (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 2 April 2026 | Viewed by 38
Special Issue Editors
Interests: analysis of EMT; tumor invasion; autophagy; apoptosis and signaling related to tumor cell migration in kidney; prostate and breast cancer
Special Issues, Collections and Topics in MDPI journals
Interests: transglutaminase type 2; non-coding RNAs; cancer cell migration and invasion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The motility of cancer cells is an important field of study that is strongly associated with migration and invasion and also represents a crucial step for addressing therapy. Understanding cell modifications and the mechanisms by which cancer cells move to new destinations could improve the identification of new therapeutic targets to prevent or reduce metastasis, increasing the survival of patients. These biological processes are connected with energy metabolism, changes in cytoplasmic structures, loss of cell adhesion, and revision of relations with the microenvironment, supported by genetic and epigenetic modifications, also triggered by drug resistance. The epithelial-to-mesenchymal transition may affect the DNA damage response, leading to genomic instability and dysregulated expression that further promotes cancer progression. The investigation of DNA repair gene networks, as well as the signaling connected with cell reprogramming (including cadherins, vimentin, and fibronectin) and the interference of non-coding RNAs, might enhance the knowledge on the ability of cells to move.
Cancer progression and metastasis are the main causes of death in patients suffering from cancer diseases. Mechanisms associated with epithelial–mesenchymal transition (EMT), cell invasion, and metastasis are not fully understood. We have studied these oncogenic processes for several years, in particular for kidney and breast cancers. Our expertise area includes research in the field of signaling pathways linked to the cell cycle, cell growth, autophagy, apoptosis, EMT, drug resistance, targeted therapy, and gene expression regulation.
The investigation of these processes is essential to discover new therapeutic targets able to enhance the lives of cancer patients.
We are pleased to invite you to contribute an article to the Special Issue “Cancer Cell Motility”.
This Special Issue aims to investigate networks involved in cancer cell invasion and migration in order to discover new therapeutic targets and drug resistance mechanisms.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: cell biology, cell biochemistry, molecular biology, cell signaling, cell cycle/proliferation, apoptosis, DNA repair, gene expression regulation, and targeted therapy.
We look forward to receiving your contributions.
Dr. Gianluca Aguiari
Dr. Nicoletta Bianchi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- EMT
- invasion
- metastasis
- p53-related signaling
- apoptosis
- autophagy
- cell cycle
- anticancer drugs
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