Immune Landscape of Multiple Myeloma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 20
Special Issue Editors
Interests: multiple myeloma; stem cell transplant; amyloidosis; plasma cell disorders; CAR-T; bi/trispecific antibodies
Interests: plasma cell disorders; multiple myeloma; amyloidosis; plasma cell leukemia; CAR-T
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. While significant advances in therapeutic strategies have been made, including immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies, the disease remains incurable for most patients, with eventual relapse and drug resistance. A growing body of evidence suggests that the immune microenvironment plays a pivotal role in MM pathogenesis, progression, and therapeutic response. The immune landscape of MM is marked by a complex interplay between malignant plasma cells and various immune cell subsets, including T cells, natural killer (NK) cells, dendritic cells, and myeloid-derived suppressor cells, many of which exhibit dysfunction or immunosuppressive phenotypes. Moreover, alterations in cytokine profiles and immune checkpoint expression contribute to immune evasion and tumor survival. Understanding the dynamic immune landscape of MM not only provides insights into disease biology but also opens avenues for novel immunotherapeutic strategies. Optimizing myeloma therapy in a thoughtful manner is crucial, particularly in the era of transformational T cell redirecting therapies (CAR T cell and bispecific antibodies), which are directly impacted by host T cell exhaustion and T cell dysfunction. This Special Issue explores the key components of the immune microenvironment in MM and their implications for disease progression and treatment optimization.
Dr. Muhamed Baljevic
Dr. Shebli Atrash
Guest Editors
Manuscript Submission Information
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Keywords
- myeloma
- immune
- T cells
- therapy
- fitness
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