Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 28 April 2026 | Viewed by 15
Special Issue Editors
Interests: cancer; lung cancer; immunotherapy; cancer biomarkers
Interests: cancer; lung cancer; immunotherapy; immune-related adverse events
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment and systemic immune responses play critical roles in the progression, prognosis, and therapeutic response of solid malignancies. In recent years, the evaluation of peripheral blood immune parameters—such as immune cell subsets, cytokines, and soluble markers—has gained prominence as a minimally invasive approach to guide clinical decision-making. Concurrently, tissue-based immune biomarkers, including immune checkpoint molecules like PD-L1, have become integral components of predictive and prognostic models across a range of solid tumors.
This Special Issue aims to highlight advances in the identification, validation, and clinical implementation of both circulating and histological immune biomarkers. We welcome original research, reviews, and perspectives focusing on the prognostic value, predictive utility, and mechanistic insights of immune biomarkers, with particular interest in studies that bridge systemic and tumor-localized immune profiling to optimize therapeutic strategies in solid tumors.
Dr. Ioannis P. Trontzas
Dr. Konstantinos Syrigos
Guest Editors
Manuscript Submission Information
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Keywords
- immune biomarkers
- solid tumors
- peripheral blood immune parameters
- circulating immune cells
- cytokines
- tissue-based biomarkers
- immune checkpoint molecules
- prognostic biomarkers
- predictive biomarkers
- tumor microenvironment
- immunotherapy response
- translational oncology
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