Genetic Alterations and the Tumor Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 50
Special Issue Editor
Interests: tumor microenvironment; cancer immunology; immune checkpoint blockade; single-cell spatial analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The evolution of cancer is governed not only by the accumulation of genetic mutations but also by the selective pressures exerted by its local ecosystem—the tumor microenvironment (TME). This complex and dynamic niche, composed of immune cells, stromal elements, vasculature, and extracellular matrices, both constrains and enables the emergence of malignant phenotypes. Somatic mutations reshape the interactions between cancer cells and their microenvironment, driving immune evasion, therapeutic resistance, and metastatic dissemination. Conversely, microenvironmental signals influence the evolutionary path of tumor genomes and sculpt clonal selection under immune and therapeutic pressures. This Special Issue seeks to highlight the emerging insights into the reciprocal relationship between genetic alterations and the TME, with an emphasis on their role in tumor progression and treatment responses. We welcome contributions spanning molecular mechanisms, cellular dynamics, and translational advances, including studies on mutational landscapes, immune modulation, spatial and single-cell analyses, and strategies to therapeutically target the tumor–microenvironment axis.
Dr. Shanye Yin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor microenvironment
- cancer immunology
- immune checkpoint blockade
- somatic mutations
- T cell signaling
- immune evasion
- macrophage polarization
- cancer immunotherapy resistance
- single-cell transcriptomics
- spatial analysis
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