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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5433 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5371 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in the Use of PET/CT and MRI in Prostate Cancer

edited by Carmelo Caldarella

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5270 | Submission Open

Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals

(This special issue belongs to the Section Methods and Technologies Development)

Feature Papers in Section “Cancer Informatics and Big Data”

edited by

Jason Roszik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5103 | Submission Open

Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4968 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions

edited by

Dimitrios H. Roukos

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4933 | Submission Open

Keywords: standard clinical management; surgery; neoadjuvant and/or adjuvant treatment; cancer immunotherapy; targeted therapy; detection and elimination of MRD

(This special issue belongs to the Section Clinical Research of Cancer)

New Perspectives in the Management of Central Nervous System (CNS) Tumors

edited by

Alessia Pellerino

, Francesco Bruno and

Teresa Somma

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4829 | Submission Open

Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors

(This special issue belongs to the Section Cancer Therapy)

Molecular Mechanisms in Bone and Soft Tissue Sarcomas

edited by

Alexander L. Lazarides

and Zachary D.C. Burke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4599 | Submission Open

Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era

edited by Talha Badar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4387 | Submission Open

Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI

(This special issue belongs to the Section Cancer Therapy)

Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives

edited by Arcangela De Nicolo and

Miguel De la Hoya

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4307 | Submission Open

Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Next-Generation Cancer Therapies

edited by

Achilleas Mitrakas

, Ioannis Lamprou and Erasmia Xanthopoulou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4253 | Submission Open

Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines

(This special issue belongs to the Section Cancer Therapy)

Advances in Ovarian Cancer Treatment: Past, Present and Future

edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4088 | Submission Open

Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4079 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies

edited by Akshay Jatin Patel and Marcus Taylor

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3871 | Submission Open

Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy

(This special issue belongs to the Section Methods and Technologies Development)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3764 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Endometrial Cancer—from Diagnosis to Management

edited by Mingxin Shi and

Xiang Zhao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3656 | Submission Open

Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention

(This special issue belongs to the Section Cancer Therapy)

Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition

edited by

Sam Beddar

and Michael D. Chuong

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3629 | Submission Open

Keywords: radiation therapy (oncology); stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR); ultra-hypofractionated and hypofractionated studies; ablative/dose-escalated studies; SBRT; SABR; and cyberknife technology; MRI guidance; tumor motion techniques and management; frame and frameless immobilization devices; SBRT/SABR dose constraints and toxicities; artificial intelligence/machine learning

(This special issue belongs to the Section Cancer Therapy)

Innovations in Addressing Disparities in Cancer

edited by

Rajesh Singh

and

Shailesh Singh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3419 | Submission Open

Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3219 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3219 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Targets for Metastatic Lung Cancer

edited by

Andrea De Giglio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3219 | Submission Open

Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3197 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3072 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

Chemotherapy and Immunotherapy of Lung Cancer

edited by

Sonia Vallet

and Klaus Hackner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3046 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Palliative Care and Pain Management in Cancer

edited by María Fernández-Gonzáles and Moira O'Connor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3025 | Submission Open

Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Technical and Technological Innovations in Head and Neck Cancer Surgery

edited by Marta Filauro

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2836 | Submission Open

Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2684 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2684 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2601 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2536 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer

edited by

Rashidul Alam Mahumud

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2525 | Submission Open

Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2354 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2266 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2210 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape

edited by Jon Mallen-St Clair

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2202 | Submission Open

Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Lymphoma Biology, Pathology and Stem Cells

edited by

Mingyi Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2105 | Submission Open

Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant

(This special issue belongs to the Section Cancer Pathophysiology)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2058 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis

edited by

Nuno Matela

and

Ana Margarida Mota

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2050 | Submission Open

Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Insights in the Management of Resectable Esophageal Malignancy

edited by

Tania Triantafyllou

and Dimitrios A. Theodorou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1934 | Submission Open

Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection

(This special issue belongs to the Section Methods and Technologies Development)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1672 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Cutaneous Metastases: State-of-the-Art Research and Management

edited by Marios N. Papadakis and

Dimitra Koumaki

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1631 | Submission Open

Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes

(This special issue belongs to the Section Cancer Metastasis)

At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition

edited by

Kenta Masui

and

Linlin Guo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1568 | Submission Open

Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma

(This special issue belongs to the Section Cancer Pathophysiology)

Breast Cancer Research and Treatment

edited by

Huaitian Liu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1478 | Submission Open

Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1477 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

Accelerated Partial Breast Irradiation

edited by Roxolyana Abdah-Bortnyak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1414 | Submission Open

Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy

(This special issue belongs to the Section Cancer Therapy)

Advanced Research in Surgical Treatment for Spinal Tumors

edited by Alessandro Gasbarrini, Stefano Bandiera and

Giuseppe Tedesco

submission deadline 31 Dec 2025 | 1 articles | Viewed by 733 | Submission Open

Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes

edited by

Andrea Dell'Amore

and

Alessio Campisi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 566 | Submission Open

Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment

(This special issue belongs to the Section Clinical Research of Cancer)

Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation

edited by

Barbara Kofler

, Niels van Heerbeek, Giulia Molinari and Benedikt Hofauer

submission deadline 31 Dec 2025 | Viewed by 560 | Submission Open

Keywords: facial nerve; facial nerve reanimation; head and neck cancer; facial reconstructive surgery

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Dec 2025 | 2 articles | Viewed by 513 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

edited by Erlinda M. Gordon,

Sant P. Chawla

and Frederick L. Hall

submission deadline 31 Dec 2025 | Viewed by 437 | Submission Open

Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

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