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Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 849

Special Issue Editors


E-Mail Website
Guest Editor
Sarcoma Oncology Research Center, Santa Monica, CA 90403, USA
Interests: sarcoma; gene therapy; natural killer cell therapy; immune and cell-cycle checkpoint inhibitors; tumor targeting

E-Mail Website
Guest Editor
Sarcoma Oncology Research Center, Santa Monica, CA 90403, USA
Interests: sarcoma; gene therapy; natural killer cell therapy; immune and cell-cycle checkpoint inhibitors; tumor targeting
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Sarcoma Oncology Research Center, Santa Monica, CA 90403, USA
Interests: cancer gene therapy; targeted gene delivery; cyclin G1; oncogenic drivers along the CCNG1 pathway; retroviral vector cloning; targeting pharmaceutical agents to injured tissues
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,  

This Special Issue is a continuation of our previous Special Issue, “Innovations in Soft Tissue Sarcoma Diagnosis and Treatment” (https://www.mdpi.com/journal/cancers/special_issues/Soft_Tissue_Sarcoma_Diagnosis).

Recent advances in genetic screening, molecular profiling, targeted therapy, gene therapy, and immunotherapy for soft tissue sarcomas (STS) have evoked increasing optimism in the medical and scientific community. Hence, we must reflect on the many faces of STS and current innovations in its diagnosis and treatment. STS is a rare cancer involving mesodermal tissues. Surgical resection is the standard of care for localized disease; however, the recurrence rate is high and the prognosis for advanced STS is poor, with a median survival of 8–13 months.

This Special Issue, entitled “Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)”, will include review articles and original clinical and translational research articles that are hypothesis-generating toward the development of precision medicine for STS.

Dr. Erlinda M. Gordon
Dr. Sant P. Chawla
Dr. Frederick L. Hall
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • soft tissue sarcoma
  • gene therapy
  • natural killer cell therapy
  • immune and cell cycle checkpoint inhibitors
  • targeted therapy

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Published Papers (1 paper)

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Review

23 pages, 848 KB  
Review
Precision-Oriented Reconstruction After Spinal Sarcoma Resection: Integrating Surgical Strategy, Biologic Risk, and Emerging Technologies
by Tanner Carcione, Bradley Callas, Jack Thiara, Walter N. Jungbauer, Jonathan Jeger and Edward Reece
Cancers 2026, 18(10), 1555; https://doi.org/10.3390/cancers18101555 - 11 May 2026
Viewed by 212
Abstract
Background/Objectives: Primary spinal sarcomas, encompassing both bone and soft tissue histotypes, demand individualized reconstruction due to heterogeneous tumor biology, anatomic complexity, and host environments compromised by radiation, systemic therapy, or prior surgery. This narrative review reframes post-resection spinal reconstruction through a precision-medicine [...] Read more.
Background/Objectives: Primary spinal sarcomas, encompassing both bone and soft tissue histotypes, demand individualized reconstruction due to heterogeneous tumor biology, anatomic complexity, and host environments compromised by radiation, systemic therapy, or prior surgery. This narrative review reframes post-resection spinal reconstruction through a precision-medicine lens. Methods: A structured literature review was performed using PubMed and Scopus, targeting articles published between 2000 and 2026. Searches encompassed spinal sarcoma reconstruction, radiation and fusion, biologic reconstruction, and emerging technologies. Results: Tumor grade, radiation exposure, and systemic therapy timing emerge as multiplicative determinants of reconstructive environment quality, with drug-class-specific perioperative effects warranting stratified management. Vascularized bone grafts achieve reliable fusion in compromised hosts where avascular constructs fail. A precision-oriented reconstructive ladder is proposed as a conceptual, hypothesis-generating framework to guide strategy selection. Hybrid PSI-VBG constructs may further expand reconstructive possibilities. The evidence base remains largely composed of small, retrospective series. Conclusions: Individualized strategies anchored in tumor biology and host environment are the cornerstone of durable spinal sarcoma reconstructions. The proposed framework requires prospective, multi-institutional validation. Standardized outcome definitions, prospective registries, and histotype-stratified analyses are needed to advance the field. Full article
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