New Insights into Pheochromocytoma and Paraganglioma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 513
Special Issue Editor
Special Issue Information
Dear Colleagues,
The clinical care of patients with pheochromocytoma and paraganglioma, known together as PPGL, has been constantly improving in recent years, based on sophisticated biochemical diagnosis, functional imaging, or genetic analyses to detect germline pathogenic variants. All of these methods, however, impose significant economic burdens and may not be universally available.
Given the low annual incidence of PPGL (0.04-0.66 per 100.000), centers have to serve a population of 1.5 million to diagnose, treat, and follow 10 new patients per year at best. Available retrospective studies from single centers often suffer from a small number and/or incomplete characterization of patients or insufficient follow-up; multicenter studies follow non-uniform protocols as to the selection, clinical, biochemical, radiological, and genetic characterization or follow-up of patients.
The scope of this Special Issue of Cancers aims to include studies on biochemical (not necessarily chromatography/mass spectrometry), genetic (including neuroendocrine panels), or functional imaging procedures for diagnosis and follow-up, methods preferably approved by national bodies or international regulations, on genotype–phenotype interactions of hereditary compared to sporadic PPGL or research concerning long-term prognostic data based on pertinent guidelines (1). Multicenter cooperations are most welcome, but should include desirable standards (2). Authors are encouraged to submit their work in accordance with guidelines enhancing the quality and transparency of health research (https://www.equator-network.org/reporting-guidelines/stard/) in order to avoid potential statistical errors.
Dr. Wolfgang Raber
Guest Editor
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Keywords
- pheochromocytoma
- paraganglioma
- diagnosis
- genetics
- imaging
- long-term follow-up
- standards
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