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Cancers, Volume 17, Issue 24

December-2 2025 - 150 articles

Cover Story: Chimeric antigen receptor (CAR)-based therapies are rapidly evolving, particularly in challenging diseases such as acute myeloid leukemia (AML). This review summarizes recent advances in CAR engineering aimed at improving specificity, safety, and efficacy, including modular receptor architectures, logic-gated activation strategies, functional armoring approaches, gene-editing technologies, and emerging CAR platforms based on alternative immune cell types beyond conventional T-cell therapies. We highlight how these fine-tuned designs may reshape cellular immunotherapy strategies against AML and guide future development toward more controlled, adaptable, and personalized immune cell therapies. View this paper
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Articles (150)

  • Review
  • Open Access
414 Views
18 Pages

HCC in the Era of Emerging MASH: The Role of Ultrasound in Surveillance and New Sonographic Features in Diagnosis

  • Antonio Giorgio,
  • Massimo De Luca,
  • Anna Lombardi,
  • Emanuela Ciracì,
  • Valeria Cosima Rollo,
  • Antonella Di Sarno,
  • Luca Montesarchio,
  • Giuseppe Stella and
  • Valentina Giorgio

18 December 2025

Conventional ultrasound (US) has long been central to hepatocellular carcinoma (HCC) surveillance in cirrhotic patients, due to its low cost, wide availability, non-invasiveness, and adequate sensitivity for detecting small nodules. However, its spec...

  • Article
  • Open Access
412 Views
17 Pages

MRI-Derived Body Composition and Breast Cancer Risk in Postmenopausal Women: UK Biobank Study

  • Livingstone Aduse-Poku,
  • Lusine Yaghjyan,
  • Stephen E. Kimmel,
  • Susmita Datta,
  • Shama D. Karanth,
  • Jae Jeong Yang,
  • Caretia Washington and
  • Dejana Braithwaite

18 December 2025

Background: Obesity is a risk factor for breast cancer mortality in postmenopausal women. However, it remains unclear which specific components of adipose tissue and skeletal muscle are associated with risk. This study assessed the associations betwe...

  • Article
  • Open Access
334 Views
23 Pages

Exploration of Predictive Factors for Acute Radiotherapy-Induced Gastro-Intestinal Symptoms in Prostate Cancer Patients

  • Pauline De Bruyn,
  • Malgorzata Klass,
  • Alain Van Muylem,
  • Nicolas Jullian,
  • François-Xavier Otte,
  • Romain Diamand and
  • Jean-Charles Preiser

18 December 2025

Background: Acute gastrointestinal (GI) toxicity is a frequent adverse effect of pelvic radiotherapy (RT) in prostate cancer and predicts chronic complications. Identifying predictive factors, especially modifiable ones, is essential to guide support...

  • Article
  • Open Access
342 Views
11 Pages

18 December 2025

Objective: This study aimed to investigate annual and seasonal trends, as well as regional differences, in female breast cancer mortality in Hungary between 2004 and 2023. Methods: Data on cancer mortality were obtained from the publicly available na...

  • Review
  • Open Access
365 Views
32 Pages

Silent Players, Loud Impact: The Influence of lncRNAs on Melanoma Progression

  • Kajetan Kiełbowski,
  • Maciej Ćmil,
  • Aleksandra Dach,
  • Aleksandra Cole,
  • Oliwia Jerzyńska,
  • Estera Bakinowska,
  • Paulina Plewa and
  • Andrzej Pawlik

18 December 2025

Non-coding RNA (ncRNA) encompasses a large family of molecules that are crucial regulators of gene expression. This family includes microRNA, piwi-interacting RNA, and long non-coding RNA (lncRNA); each class is associated with different mechanisms o...

  • Review
  • Open Access
364 Views
11 Pages

Would Biopsy Change the Management of Kidney Cancer in the Coming Decade? The Role of Biopsy in Small Renal Masses: A Narrative Review

  • Łukasz Dariusz Lisak,
  • Paweł Hełka,
  • Aleksandra Kaźmierczak,
  • Anna Kaletka,
  • Sarah Sampers,
  • Piotr Kania,
  • Miłosz Jasiński and
  • Maciej Salagierski

18 December 2025

Renal cell carcinoma (RCC) is the 14th-most common cancer worldwide, with 434,419 new cases recorded in 2022 [...]

  • Article
  • Open Access
269 Views
13 Pages

Pregnancy vs. Postpartum Breast Cancer: Distinct Tumor Biology and Survival Trends in a Contemporary Cohort

  • Elena Jane Mason,
  • Alba Di Leone,
  • Beatrice Carnassale,
  • Antonio Franco,
  • Cristina Accetta,
  • Sabatino D’Archi,
  • Flavia De Lauretis,
  • Federica Gagliardi,
  • Elisabetta Gambaro and
  • Marzia Lo Russo
  • + 17 authors

18 December 2025

Background: Pregnancy-associated breast cancer (PABC), defined as breast cancer diagnosed during pregnancy or within one year postpartum, is a unique and clinically challenging entity. Evidence suggests that tumors diagnosed during pregnancy (PrBC) a...

  • Article
  • Open Access
430 Views
17 Pages

Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party

  • Agnieszka Tomaszewska,
  • Grzegorz W. Basak,
  • Christophe Peczynski,
  • Emmanuelle Polge,
  • Pascale Ambron,
  • William Boreland,
  • Simona Sica,
  • Mutlu Arat,
  • Jakob Passweg and
  • Jose Luis Lopez Lorenzo
  • + 12 authors

18 December 2025

Background: Haploidentical hematopoietic cell transplantations (haplo-HCTs) with post-transplant cyclophosphamide (PT-Cy) are standard practice, but complications causing morbidity and mortality are not well described. Methods: The aim of this prospe...

  • Article
  • Open Access
343 Views
11 Pages

Impact of Frailty on the Outcomes of Patients with Pancreatic Cancer Undergoing Neoadjuvant Therapy

  • Nicholas R. Williams,
  • Thomas Leuschner,
  • Amanda K. Walsh,
  • Kayla Gault,
  • Amber Ingram,
  • Alex B. Blair,
  • Susan Tsai,
  • Timothy M. Pawlik,
  • Mary E. Dillhoff and
  • Jordan M. Cloyd

18 December 2025

Background: Neoadjuvant therapy (NT) is increasingly utilized for patients with localized pancreatic ductal adenocarcinoma (PDAC). Toxicities during NT are common, often leading to the inability to undergo surgical resection, yet risk factors for att...

  • Article
  • Open Access
327 Views
17 Pages

18 December 2025

Background: Appendiceal neoplasms are rare, but recent data indicate a rising trend, particularly in patients under the age of 50. These tumours are often diagnosed incidentally during histopathological examination. This study has aimed to examine th...

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Cancers - ISSN 2072-6694