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Cancers
Special Issues
Oral Cancer: Prevention and Early Detection (2nd Edition)
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Oral Cancer: Prevention and Early Detection (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1380

Special Issue Editors

Dr. Gianluca Tenore

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Interests: oral medicine; oral pathology; oral cancer; oral surgery; laser in dentistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Umberto Romeo

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Interests: oral pathology; oral medicine; oral cancer; oral surgery; laser
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral cancer is a serious disease that causes thousands of deaths each year. Improved prevention methods can reduce the risk of developing this disease. This can be achieved through a better understanding of the disease and its risk factors. In addition, the use of innovative approaches to enable early diagnosis will enhance the outcome of case management, improving the quality of life of our patients and consequently increasing patient survival rates.

The aim of this Special Issue is to provide a “research update” on the different risk factors and studies investigating the effectiveness of innovative approaches to achieve early detection of oral cancer.

In this Special Issue, original research articles and reviews are welcome, and we particularly encourage the submission of multicentric studies. Research areas may include (but are not limited to) the following:

  • The correlation of human papillomavirus with oral cancer.
  • Non-invasive biomarkers including microRNAs.
  • Potentially malignant oral disorders and the risk of malignant transformation.
  • Tobacco, alcohol, and family history as risk factors.
  • Chronic trauma and malignant transformation.
  • The impact of early diagnosis of oral cancer on survival rate.
  • Innovative biopsy techniques for precise and early diagnosis of oral cancer.

We look forward to receiving your contributions.

Regards,

Dr. Gianluca Tenore
Prof. Dr. Umberto Romeo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cancer
  • oral squamous cell carcinoma
  • alcohol and tobacco
  • human papillomavirus (HPV)
  • biomarkers
  • biopsy and liquid biopsy
  • oral potentially malignant disorders (OPMDs)
  • oral pathology and oral medicine
  • oral and maxillofacial surgery
  • radiotherapy and chemotherapy

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Published Papers (1 paper)

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21 pages, 1727 KB  
Review
Immune Evasion in Head and Neck Squamous Cell Carcinoma: Roles of Cancer-Associated Fibroblasts, Immune Checkpoints, and TP53 Mutations in the Tumor Microenvironment
by Chung-Che Tsai, Yi-Chiung Hsu, Tin-Yi Chu, Po-Chih Hsu and Chan-Yen Kuo
Cancers 2025, 17(15), 2590; https://doi.org/10.3390/cancers17152590 - 7 Aug 2025
Viewed by 1092
Abstract
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy characterized by complex interactions within the tumor microenvironment (TME) that facilitate immune evasion and tumor progression. The TME consists of diverse cellular components, including cancer-associated fibroblasts, immune and endothelial cells, and [...] Read more.
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy characterized by complex interactions within the tumor microenvironment (TME) that facilitate immune evasion and tumor progression. The TME consists of diverse cellular components, including cancer-associated fibroblasts, immune and endothelial cells, and extracellular matrix elements, that collectively modulate tumor growth, metastasis, and resistance to therapy. Immune evasion in HNSCC is orchestrated through multiple mechanisms, including the suppression of cytotoxic T lymphocytes, recruitment of immunosuppressive cells, such as regulatory T and myeloid-derived suppressor cells, and upregulation of immune checkpoint molecules (e.g., PD-1/PD-L1 and CTLA-4). Natural killer (NK) cells, which play a crucial role in anti-tumor immunity, are often dysfunctional within the HNSCC TME due to inhibitory signaling and metabolic constraints. Additionally, endothelial cells contribute to tumor angiogenesis and immune suppression, further exacerbating disease progression. Recent advancements in immunotherapy, particularly immune checkpoint inhibitors and NK cell-based strategies, have shown promise in restoring anti-tumor immunity. Moreover, TP53 mutations, frequently observed in HNSCC, influence tumor behavior and therapeutic responses, highlighting the need for personalized treatment approaches. This review provides a comprehensive analysis of the molecular and cellular mechanisms governing immune evasion in HNSCC with a focus on novel therapeutic strategies aimed at improving patient outcomes. Full article
(This article belongs to the Special Issue Oral Cancer: Prevention and Early Detection (2nd Edition))
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