Chromatin-Remodeling Factors in Cancer Cells
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 17
Special Issue Editor
Interests: epigenetics; chromatin biology; virus-induced cancer; transcription
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chromatin-remodeling and transcription factors are key regulators of the gene expression programs that govern cancer initiation, progression, and response to therapy. Their dysregulation alters chromatin architecture, reprograms cellular states, and creates vulnerabilities that can be therapeutically exploited. As our tools for interrogating the cancer epigenome evolve, new opportunities are emerging for targeting these pathways with precision.
This Special Issue invites original research, reviews, and perspectives exploring the roles of chromatin remodelers and transcription factors in cancer biology and treatment. We welcome studies employing advanced methodologies such as CRISPR-based functional screens, single-cell epigenomics, chromatin conformation capture (e.g., Hi-C), ATAC-seq, and integrative multiomics. Submissions highlighting therapeutic strategies, ranging from small molecule inhibitors and PROTACs to epigenetic drugs and combination therapies, are strongly encouraged.
Topics of interest include mechanistic insights into chromatin dynamics, transcriptional reprogramming in drug resistance, enhancer hijacking, synthetic lethality involving epigenetic regulators, and novel therapeutic platforms targeting chromatin accessibility and transcription factor networks.
Through this Special Issue, we will showcase cutting-edge research that advances our understanding of epigenetic and transcriptional control in cancer, aiming to inform next-generation therapeutic strategies.
Dr. Sudhakar Jha
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chromatin remodeling
- transcription factors
- epigenetic therapy
- cancer epigenomics
- SWI/SNF complex
- CRISPR functional screens
- single-cell epigenomics
- gene regulation in cancer
- therapy resistance
- targeted cancer therapies
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