Advances in the Molecular Biology of Sarcoma and Drug Development

Dear Colleagues,

Sarcomas are a diverse group of cancers arising from connective tissues, presenting significant challenges in drug development due to their rarity and heterogeneity. Traditional treatments have primarily involved surgery, radiation, and chemotherapy. Although the outcome and survival rate for some sarcoma subtypes have improved over time, the current treatment regimens remain efficaciously limited.  Recurrent and metastatic diseases remain a major obstacle in clinic.

Recent advances in understanding the genetic and epigenetic alterations of sarcomas and the associated signaling pathways hold promise for precise diagnosis and drug development. In this Special Issue, experts in this field will review and discuss the advances in the molecular biology of sarcoma, drug development, and personalized medicine.

Prof. Dr. Francis Hornicek
Prof. Dr. Zhenfeng Duan
Guest Editors

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