Advances in the Molecular Biology of Sarcoma and Drug Development

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 56

Special Issue Editors


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Guest Editor
Department of Orthopedic Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA
Interests: sarcoma; molecular biology; kinases; drug development; multidrug resistance

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Guest Editor
Department of Orthopaedics, University of Miami, Miami, FL 33136, USA
Interests: osteosarcoma; chemotherapy; mifamurtide

Special Issue Information

Dear Colleagues,

Sarcomas are a diverse group of cancers arising from connective tissues, presenting significant challenges in drug development due to their rarity and heterogeneity. Traditional treatments have primarily involved surgery, radiation, and chemotherapy. Although the outcome and survival rate for some sarcoma subtypes have improved over time, the current treatment regimens remain efficaciously limited.  Recurrent and metastatic diseases remain a major obstacle in clinic.

Recent advances in understanding the genetic and epigenetic alterations of sarcomas and the associated signaling pathways hold promise for precise diagnosis and drug development. In this Special Issue, experts in this field will review and discuss the advances in the molecular biology of sarcoma, drug development, and personalized medicine.

Prof. Dr. Francis Hornicek
Prof. Dr. Zhenfeng Duan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sarcoma
  • sarcoma models
  • kinases
  • drug development
  • multidrug resistance
  • targeted therapy
  • immunotherapy

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Published Papers

This special issue is now open for submission.
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