At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 4404
Special Issue Editors
Interests: cancer metabolism; epigenetics; mTOR complex; glioblastoma; molecular pathology; molecular pathology of brain tumors; neuropathology; experimental pathology
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; therapy; signaling pathway; HER; EGF; Wnt; notch; TGF-β; mTOR; PD-1/PD-L1
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the Special Issue “At the Interface of Genetics, Epigenetics, and Metabolism in Cancer”, available at: https://www.mdpi.com/journal/cancers/special_issues/ATIOGEAMIC.
Recent advancements in comprehending cancer genomics have culminated in a cancer diagnostic scheme classified by tissue and cell type of origin and, more importantly, by its molecular-genetic composition. The molecular aspect of cancer classification is based primarily on oncogene gains, tumor suppressor losses, and associated transcriptomic shifts. However, the phenotypes of cancer cells are represented more by profound alterations in cellular metabolism and epigenetic landscape, and it is of particular importance that oncogenic genomic aberration enables tumor cells to maximize their survival and drug resistance by taking advantage of the dynamic flow of nutrients in systemic microenvironments. Furthermore, changes in nutrient uptake and utilization directly affect chromatin structure, which is central to this dynamic behavior. This Special Issue will highlight a set of recent discoveries on metabolic and epigenetic reprogramming in cancer; in particular, it will focus on the “co-dependency” of genetics, epigenetics, and metabolism, which contributes to the aggressive phenotypes of cancer cells, suggesting that these aberrations do not constitute a one-way street to sustaining cancer cell survival on their own, but that the mutual interdependency of genetics, epigenetics, and metabolism could be a key to facilitating tumor progression, which will be, at the same time, an Achilles’ heel. These underscore the integration of genetic mutations with metabolic and epigenetic reprogramming in cancer, suggesting a new means to identify patient subsets suitable for specific precision therapeutics.
We look forward to your submissions.
Dr. Kenta Masui
Dr. Linlin Guo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer metabolism
- epigenetic reprogramming
- histone modification
- DNA methylation
- chromatin structure
- intermediary metabolites
- microenvironment
- mTOR complexes
- glioblastoma
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