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Advanced Research in Surgical Treatment for Spinal Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 610

Special Issue Editors


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Guest Editor
1. Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
2. Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
Interests: spine surgery; spinal tumors; degenerative spine disease; spine deformity

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Guest Editor
Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Interests: spine surgery; spinal tumors; degenerative spine disease; spine deformity

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Guest Editor
Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Interests: spine surgery; spinal tumors; degenerative spine disease; spine deformity
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Special Issue Information

Dear Colleagues,

Tumors affecting the spine represent a challenging pathologic entity that requires collaboration among practitioners with multiple medical specialties. The life expectancy of patients affected by tumors of the spine (primary or metastatic) has increased considerably, mainly due to advances in the field of oncologic therapies, radiotherapy, and surgical treatments.

Molecular targeted therapy is changing the way in which we treat cancer. Knowing the molecular signature of a specific tumor can lead to the development of targeted therapy and improve outcomes.

In parallel, the use of spinal surgery has considerably increased worldwide over the last 30 years, leading to the development of new and often minimally invasive surgical approaches and techniques. Tremendous advances have been made in the field of reconstructive techniques after tumor resection, as well as in the use of surgical navigation and robotic-assisted surgery.

For this Special Issue, we invite articles on surgical treatment for spinal tumors and innovative approaches associated with surgery (such as interventional radiology, radiosurgery, robotic-assisted surgery, and electrochemotherapy), focusing on outcomes in terms of survival, complications, recurrence, and quality of life. Both original articles and reviews are welcome, and interesting "Communication" will also be considered.

Prof. Dr. Alessandro Gasbarrini
Dr. Stefano Bandiera
Dr. Giuseppe Tedesco
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spine oncology
  • primary tumors
  • metastatic tumors
  • spondylectomy
  • en bloc resection
  • minimally invasive surgery
  • anterior reconstruction
  • biomaterials
  • radiosurgery
  • electrochemotherapy

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Published Papers (1 paper)

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Review

13 pages, 1716 KB  
Review
Intraoperative Ultrasound in the Management of Rare Lesions Involving the Intradural Extramedullary Spinal Compartment: A Quick, but Effective Helping Hand to Define the Optimal Surgical Strategy
by Alessandro Pesce, Luca Di Carlo, Mauro Palmieri, Federica Novegno, Andrea Iaquinandi, Luca Denaro, Daniele Armocida, Antonio Santoro, Maurizio Salvati, Tamara Ius and Alessandro Frati
Cancers 2025, 17(22), 3607; https://doi.org/10.3390/cancers17223607 - 8 Nov 2025
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Abstract
Intraoperative ultrasound (IOUS) is an increasingly adopted adjunctive intraoperative visualization method in spinal tumor surgery, offering real-time imaging that improves lesion localization, exposure planning, and resection control. This paper focuses on IOUS findings in rare intradural entities (neuroenteric/respiratory cysts, chronic spinal subdural hematoma, [...] Read more.
Intraoperative ultrasound (IOUS) is an increasingly adopted adjunctive intraoperative visualization method in spinal tumor surgery, offering real-time imaging that improves lesion localization, exposure planning, and resection control. This paper focuses on IOUS findings in rare intradural entities (neuroenteric/respiratory cysts, chronic spinal subdural hematoma, tethered cord/scarring, intradural extramedullary hemangioblastomas, and arachnoid cysts) where evidence remains limited. Across these lesions, IOUS typically depicts cysts as anechoic or hypoechoic cavities with definable walls and occasional septations; CSSDH is also delimited by hypoechoic subdural collections bounded by echogenic membranes; hemangioblastomas, as well as circumscribed, homogeneous nodules often with cystic components; and arachnoid webs/cysts with their boundaries and subtle subarachnoid communications. Doppler and micro-Doppler can delineate feeding and draining vessels in highly vascular tumors, while shear wave elastography provides quantitative stiffness changes that support effective detethering. IOUS complements preoperative MRI, shortens exposure, helps tailor bone and dural openings, and allows immediate assessment of residual disease. Taken together, current data and our experience support IOUS as a safe, cost-effective, and versatile intraoperative tool for rare intradural spinal pathology, while underscoring the need for prospective studies to refine sonographic criteria and validate outcome benefits. Full article
(This article belongs to the Special Issue Advanced Research in Surgical Treatment for Spinal Tumors)
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