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Advances in Ovarian Cancer Treatment: Past, Present and Future

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 4136

Special Issue Editors


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Guest Editor
1st Department of Obstetrics & Gynecology, Aristotle University of Thessaloniki, “Papageorgiou” General Hospital, Thessaloniki, Greece
Interests: gynecological oncology; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; cytoreductive surgery; HIPEC; minimal invasive surgery

E-Mail Website
Guest Editor
1st Department of Obstetrics & Gynecology, Aristotle University of Thessaloniki, “Papageorgiou” General Hospital, Thessaloniki, Greece
Interests: gynecological oncology; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; breast cancer; cytoreductive surgery; minimal invasive surgery

Special Issue Information

Dear Colleagues,

Ovarian cancer is the most lethal gynecological malignancy in relation to cervical and endometrial cancers. It is associated with the worst prognosis and a high mortality rate. In most cases (75%), ovarian cancer is diagnosed at an advanced stage due to its asymptomatic and silent growth of the tumor, delayed onset of symptoms and lack of proper screening.

 However, important steps have been made in the treatment of advanced ovarian cancer concerning surgery, adjuvant or neoadjuvant chemotherapy drug regiments and maintenance targeted therapy. These resulted in an improved progression-free and overall survival, and a better quality of life of these patients. Nevertheless, even with the new treatment improvements, 80% of the patients will experience recurrence.

This Special Issue aims to highlight the current practice and advances in ovarian cancer treatment, including cytoreductive surgery, HIPEC, new chemotherapeutic agents and maintenance targeted therapy.

Dr. Dimitrios Tsolakidis
Dr. Dimitrios Zouzoulas
Guest Editors

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Keywords

  • ovarian cancer
  • cytoreductive surgery
  • HIPEC
  • chemotherapy
  • immunotherapy

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Published Papers (2 papers)

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13 pages, 948 KB  
Article
The Real-World Impact of PARP Inhibitor Maintenance Therapy in High Grade Serous Tubo-Ovarian and Peritoneal Cancers
by Maryam Al-Ani, Bahaaeldin Baraka, Navin Mathiyalagan, Muhammad Adeel Sarwar, Avinash Segaran, Wafaa Abuzahra, Alayna Radford, Kersty Buxton, Lalith Seneviratne, Santhanam Sundar, Anjana Anand, David Nunns, Karin Williamson, Ben Wormald, Ketankumar Gajjar and Srinivasan Madhusudan
Cancers 2025, 17(21), 3591; https://doi.org/10.3390/cancers17213591 - 6 Nov 2025
Viewed by 886
Abstract
Background: Pivotal clinical trials have led to the routine clinical use of PARP inhibitor (PARPi) (olaparib, niraparib, or rucaparib) maintenance therapy in high-grade serous tubo-ovarian and peritoneal cancers. Whether various PARPis have comparable clinical impact in the real-world is an area of ongoing [...] Read more.
Background: Pivotal clinical trials have led to the routine clinical use of PARP inhibitor (PARPi) (olaparib, niraparib, or rucaparib) maintenance therapy in high-grade serous tubo-ovarian and peritoneal cancers. Whether various PARPis have comparable clinical impact in the real-world is an area of ongoing investigation. Methods: We conducted a retrospective study of all patients who received PARPi maintenance therapy at Nottingham Cancer Centre from October 2017 to April 2025. Clinical data were extracted from multidisciplinary team electronic health records, including age, BRCA mutation status, HRD status, treatment history, type of PARP inhibitor received, progression-free survival (PFS), and overall survival (OS). Results: A total of 177 patients had received PARPi therapy with a mean age of 63 years at diagnosis. In all, 94/177 (53.1%) had received PARPi as primary maintenance, while 83/177 (46.9%) were treated in the recurrent setting. All together, 25/177 (14.1%) had BRCA1 germline mutation and 21/177 (11.9%) had BRCA2 germline mutation. In the primary olaparib setting, PFS was significantly better in BRCA2 germline-mutated patients compared to BRCA1 germline-mutated patients [median PFS was not reached vs. 29.0 months, respectively, p = 0.002]. In BRCA, wild-type patients receiving primary niraparib, median PFS was 11 months. Median PFS for patients with upfront surgery was 37 months compared to 19 months in the interval debulking group but not significant (p = 0.49). In the recurrent setting, there was no significant difference in median PFS between niraparib and rucaparib [10 months vs. 9 months, p = 0.594]. Conclusions: BRCA2 germline-mutated patients obtained significantly greater benefit from olaparib compared to BRCA1-mutated patients. PFS benefit from niraparib (primary or recurrent setting) is comparable to clinical trials. There was no difference in benefit between niraparib and rucaparib in the recurrent setting. Full article
(This article belongs to the Special Issue Advances in Ovarian Cancer Treatment: Past, Present and Future)
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16 pages, 1441 KB  
Systematic Review
An Updated Meta-Analysis on Long-Term Outcomes Following Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer
by Nadine El Kassis, Myriam Jerbaka, Rime Abou Chakra, Christopher El Hadi, Wissam Arab, Houssein El Hajj, Donal J. Brennan and David Atallah
Cancers 2025, 17(9), 1569; https://doi.org/10.3390/cancers17091569 - 5 May 2025
Cited by 2 | Viewed by 2554
Abstract
Ovarian cancer is the leading cause of death among gynecological malignancies [...] Full article
(This article belongs to the Special Issue Advances in Ovarian Cancer Treatment: Past, Present and Future)
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