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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 30 Jun 2026 | 1 articles | Viewed by 826 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 601 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 30 Jun 2026 | Viewed by 269 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials

edited by Caterina Ricci and

Maria Grazia Ortore

submission deadline 30 Jun 2026 | Viewed by 240 | Submission Open

Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization

Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders

edited by

Wan Lee

submission deadline 30 Jun 2026 | Viewed by 213 | Submission Open

Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies

Bacterial Molecular Biology: Stress Responses and Adaptation

edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa

submission deadline 30 Jun 2026 | Viewed by 177 | Submission Open

Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks

(This special issue belongs to the Section Molecular Biology)

Exercise Immunology: Molecular Mechanisms and Health Applications

edited by

Dorota Kostrzewa-Nowak

Robert Nowak

, Michał Sławiński and

Patrizia Proia

submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open

Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors

(This special issue belongs to the Section Molecular Biology)

Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System

edited by

Dimitrios Kouroupis

and

Enrico Ragni

submission deadline 30 Jun 2026 | Viewed by 137 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles ; musculoskeletal regeneration ; immunomodulation ; anabolism ; cell therapy ; cell-free therapy ; secretome

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition

edited by

Adriana Georgescu

submission deadline 30 Jun 2026 | Viewed by 131 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation

edited by Konstantinos Venetis,

Nicola Fusco

and Marianna D'Ercole

submission deadline 30 Jun 2026 | Viewed by 127 | Submission Open

Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology

(This special issue belongs to the Section Molecular Biomarkers)

Non-Invasive Biomarker Screening in Cancer

edited by

Iqbal Mahmud

and F. G. Pinto

submission deadline 30 Jun 2026 | Viewed by 126 | Submission Open

Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies

(This special issue belongs to the Section Molecular Biomarkers)

Forces Driving Macromolecular Recognition: Role in Drug Design and Discovery

edited by David P. Remeta and

Conceição A. Minetti

submission deadline 30 Jun 2026 | Viewed by 110 | Submission Open

Keywords: macromolecular recognition; drug design and discovery; biomolecular structure and dynamics; computational modeling; ligand– receptor binding energetics; drug-target interactions; thermodynamic forces; protein-ligand binding; drug discovery and optimization; protein-nucleic acid interactions; intrinsically disordered proteins; protein aggregation and disease

(This special issue belongs to the Section Chemical Biology)

Molecular and Physiological Regulation of Biomechanical Signalling

edited by

Lars Kaestner

submission deadline 30 Jun 2026 | Viewed by 110 | Submission Open

Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics

Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application

edited by

Nebojsa Nick Knezevic

and

Aleksandar Sič

submission deadline 30 Jun 2026 | Viewed by 102 | Submission Open

Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders

(This special issue belongs to the Section Biological Factors)

Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition

edited by

Mateusz Banach

submission deadline 30 Jun 2026 | Viewed by 93 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Chemical Biology)

Novel Insights into Epithelial Mesenchymal Transition (EMT) in Cancer

edited by

Shuya Yano

submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open

Keywords: EMT; epithelial– mesenchymal plasticity; hybrid E/M states; single-cell; spatial transcriptomics/proteomics; multiplex IHC/IF; RNA in situ; CTCs; ctDNA; radiomics; computational pathology; immune evasion; therapy resistance; metastasis; biomarkers; reporting standards; reproducibility; clinical translation

(This special issue belongs to the Section Molecular Medicine)

Second Messenger Systems in Cellular Communication and Disease

edited by

Vijay Parashar

submission deadline 30 Jun 2026 | Viewed by 87 | Submission Open

Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets

(This special issue belongs to the Section Molecular Biology)

Plant Secondary Metabolism Engineering and Bioactive Compounds

edited by

Barbara Tokarz

and

Wojciech Makowski

submission deadline 30 Jun 2026 | Viewed by 86 | Submission Open

Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Enolase: Molecular Functions and Pathological Roles in Health and Disease

edited by

Anja Pišlar

submission deadline 30 Jun 2026 | Viewed by 79 | Submission Open

Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

Multifunctional Nanocarriers for Advanced Therapy and Diagnosis

edited by

Buddhadev Layek

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles

(This special issue belongs to the Section Bio-Engineered Materials)

Nanomaterials and Their Applications in Biomedicine—2nd Edition

edited by

George Pasparakis

submission deadline 30 Jun 2026 | Viewed by 67 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

Molecular Mechanism of Viral Infection and Host Immunity in Transplantation

edited by Eva Mischak Weissinger

submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open

Keywords: allogeneic stem cell/or solid organ transplantation; immunosuppressed host; immune reconstitution; virus reactive/specific cytotoxic T-/NK-cells; immune reconstitution post-transplantation

(This special issue belongs to the Section Molecular Medicine)

Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights

edited by Anna Barbara Di Stefano

submission deadline 30 Jun 2026 | Viewed by 58 | Submission Open

Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Interactions and Microbial Biocontrol Strategies in Host-Parasite-Pest Systems

edited by Rubén Marino Cardozo

submission deadline 30 Jun 2026 | Viewed by 50 | Submission Open

Keywords: molecular interactions; bioactive molecules; pest– microbe– host systems; microbial biocontrol; eco-evolutionary mechanisms; molecular parasitology; host– parasite interactions

(This special issue belongs to the Section Cellular Biochemistry)

Novel Biomarkers and Signaling Pathways in Kidney Diseases

edited by

Eiichi Sato

submission deadline 30 Jun 2026 | Viewed by 25 | Submission Open

Keywords: kidney disease; signaling pathway; biomarkers; therapeutic strategies; molecular mechanisms

(This special issue belongs to the Section Molecular Biomarkers)

Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 15 Jul 2026 | 4 articles | Viewed by 8052 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 15 Jul 2026 | 3 articles | Viewed by 6297 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2496 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 15 Jul 2026 | Viewed by 167 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration

edited by

Young Yul Kim

submission deadline 15 Jul 2026 | Viewed by 18 | Submission Open

Keywords: biomaterials; molecular regulation; skeletal regeneration; cartilage regeneration; cell– matrix interaction; osteogenesis and chondrogenesis; mechanotransduction; immunomodulation; translational regenerative medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Regulation of Synapses in the Brain

edited by

Kunwei Wu

and Guohao Wang

submission deadline 17 Jul 2026 | 1 articles | Viewed by 1169 | Submission Open

Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Mechanisms of RNA Regulation in Inflammation

edited by

Roopa Biswas

submission deadline 17 Jul 2026 | 1 articles | Viewed by 1145 | Submission Open

Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Genetics)

Protein Acetylation and Methylation—from Gene Regulation to Epigenetics, Metabolism, and Beyond

edited by

Kangling Zhang

submission deadline 17 Jul 2026 | Viewed by 65 | Submission Open

Keywords: protein acetylation; protein methylation; histone modification; epigenetics; gene regulation; chromatin remodeling; metabolism; signal transduction; post-translational modification (PTM); proteomics; cancer biology; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 20 Jul 2026 | 3 articles | Viewed by 9786 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 20 Jul 2026 | 3 articles | Viewed by 7439 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Cellular and Non-Cellular Treatment of Stroke

edited by

David T. Harris

submission deadline 20 Jul 2026 | 1 articles | Viewed by 4937 | Submission Open

Keywords: stroke; treatment; therapy; biomolecules; stem cells

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 20 Jul 2026 | 3 articles | Viewed by 3368 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases

edited by Mirela Baus Lončar,

Anita Horvatić

and

Mirela Sedić

submission deadline 20 Jul 2026 | Viewed by 138 | Submission Open

Keywords: protective biomolecules; metabolic homeostasis; insulin resistance; cancer metabolism

(This special issue belongs to the Section Molecular Medicine)

Wound Repair and Regeneration: From Molecular and Cellular Mechanisms to New Approaches

edited by Elia Ranzato

submission deadline 20 Jul 2026 | Viewed by 79 | Submission Open

Keywords: wound repair; tissue regeneration; molecular mechanisms; cellular mechanisms; chronic wounds; fibrosis/scarring; biomaterials; stem cells; translational therapies

(This special issue belongs to the Section Molecular Medicine)

Signaling Pathways of 5-HT Receptors in Neuropsychiatric Disorders

edited by

Abdeslam Chagraoui

and

Philippe De Deurwaerdère

submission deadline 20 Jul 2026 | Viewed by 71 | Submission Open

Keywords: serotonin; 5-HT Receptors; allostery; allosteric modulators; synaptic plasticity; psychedelics; non-hallucinogenic agonists; RNA editing; Akt; GSK3; ERK; PI3K; mTOR; microglia; neuroinflammation; dopamine; glutamate; prefrontal cortex; hippocampus; nucleus accumbens; depression; schizophrenia; anxiety; addictions; cognition; biosensors; cryo-EM; phospho-proteomics

(This special issue belongs to the Section Molecular Medicine)

Developmental-Related Brain Disorders

edited by

Ricardo Rodrigues

submission deadline 20 Jul 2026 | Viewed by 61 | Submission Open

Keywords: neurogenesis; neuronal migration; cell differentiation; axon pathfinding; synaptogenesis; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Medicine)

Multi-Scale Integrative Radiobiology

edited by

Nicolas Foray

submission deadline 20 Jul 2026 | Viewed by 56 | Submission Open

Keywords: integrative radiobiology; radiosensitivity; radiosusceptibility; radiodegeneration; radiation-induced energy microdepositions; radiation-induced radical oxygen species; radiation-induced DNA damage; DNA damage recognition and repair; radiation-induced tissue injuries; radiation-induced risks

(This special issue belongs to the Section Molecular Biology)

Protein Structure Prediction in Drug Discovery, 3rd Edition

edited by

Alessandro Paiardini

submission deadline 20 Jul 2026 | Viewed by 48 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Immunometabolism and Signaling Networks in Autoimmune Rheumatic Diseases

edited by Ryu Watanabe and

Yushiro Endo

submission deadline 20 Jul 2026 | Viewed by 31 | Submission Open

Keywords: immunometabolism; intracellular signaling pathways; T-cell and B-cell metabolism; metabolic– signaling crosstalk; innate immune cell signaling

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 24 Jul 2026 | 1 articles | Viewed by 524 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction

edited by

, Qiuhua Yang,

and

submission deadline 24 Jul 2026 | Viewed by 230 | Submission Open

Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE

(This special issue belongs to the Section Molecular Medicine)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition

edited by

Clement Agoni

and

Indrani Bera

submission deadline 24 Jul 2026 | Viewed by 197 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein– protein interactions; protein– ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

New Insights into Integrins: 2nd Edition

edited by

Yoshikazu Takada

submission deadline 25 Jul 2026 | Viewed by 40 | Submission Open

Keywords: integrins; growth factors; ligands; allosteric binding; inflammation-induced activation

(This special issue belongs to the Section Biological Factors)

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 30 Jul 2026 | 1 articles | Viewed by 433 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Biomarkers in Musculoskeletal and Orthopedic Disorders

edited by

Elena De Vecchi

submission deadline 30 Jul 2026 | Viewed by 81 | Submission Open

Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis

(This special issue belongs to the Section Molecular Biomarkers)

Displaying special issue 351-400 on page 8 of 10.

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