Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".
Deadline for manuscript submissions: 15 July 2026 | Viewed by 21
Special Issue Editor
Interests: cervical spine; biomaterial; minimally invasive surgery; osteoporosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite substantial progress in musculoskeletal research, effective regeneration of skeletal and cartilage tissues remains limited by the complexity of molecular signaling networks and the highly regulated tissue microenvironment governing repair and remodeling. Emerging evidence indicates that biomaterials are not merely passive structural supports but active regulators of cellular behavior through precise modulation of molecular pathways related to osteogenesis, chondrogenesis, inflammation, angiogenesis, and mechanotransduction.
This Special Issue focuses on the molecular regulation underlying biomaterials and engineering strategies for skeletal and cartilage regeneration. We particularly welcome studies elucidating biomaterial-driven signaling mechanisms, including cell–matrix interactions, immune modulation, extracellular matrix remodeling, and mechano-responsive pathways. Contributions addressing advanced biomaterial designs—such as bioactive, smart, injectable, or scaffold-based systems—integrated with molecular biology and systems-level analyses are strongly encouraged.
In addition to fundamental and preclinical investigations, this Special Issue also aims to bridge fundamental molecular insights with translational and clinically relevant applications. Studies demonstrating proof-of-concept translational strategies, disease-oriented models, or pathways toward clinical implementation will be especially valued. By integrating molecular science, biomaterials engineering, and translational research, this Special Issue seeks to advance the development of next-generation regenerative therapies for bone and cartilage repair.
Dr. Young Yul Kim
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- biomaterials
- molecular regulation
- skeletal regeneration
- cartilage regeneration
- cell–matrix interaction
- osteogenesis and chondrogenesis
- mechanotransduction
- immunomodulation
- translational regenerative medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
