Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration

Dear Colleagues,

Despite substantial progress in musculoskeletal research, effective regeneration of skeletal and cartilage tissues remains limited by the complexity of molecular signaling networks and the highly regulated tissue microenvironment governing repair and remodeling. Emerging evidence indicates that biomaterials are not merely passive structural supports but active regulators of cellular behavior through precise modulation of molecular pathways related to osteogenesis, chondrogenesis, inflammation, angiogenesis, and mechanotransduction.

This Special Issue focuses on the molecular regulation underlying biomaterials and engineering strategies for skeletal and cartilage regeneration. We particularly welcome studies elucidating biomaterial-driven signaling mechanisms, including cell–matrix interactions, immune modulation, extracellular matrix remodeling, and mechano-responsive pathways. Contributions addressing advanced biomaterial designs—such as bioactive, smart, injectable, or scaffold-based systems—integrated with molecular biology and systems-level analyses are strongly encouraged.

In addition to fundamental and preclinical investigations, this Special Issue also aims to bridge fundamental molecular insights with translational and clinically relevant applications. Studies demonstrating proof-of-concept translational strategies, disease-oriented models, or pathways toward clinical implementation will be especially valued. By integrating molecular science, biomaterials engineering, and translational research, this Special Issue seeks to advance the development of next-generation regenerative therapies for bone and cartilage repair.

Dr. Young Yul Kim
Guest Editor

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