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Biomolecules
Special Issues
Cellular and Molecular Biology of Neurodevelopment
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Cellular and Molecular Biology of Neurodevelopment

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1753

Special Issue Editor

Dr. David M. Feliciano

E-Mail Website
Guest Editor
Department of Biological Sciences, Clemson University, Clemson, SC, USA
Interests: neural stem cells; microglia; tuberous sclerosis complex; extracellular vesicles; mTOR pathway

Special Issue Information

Dear Colleagues,

It is critical to determine the cellular and molecular events required to generate the vast number and types of cells in the nervous system to define how it functions and provide insight into neurodevelopmental disorders. There is a dearth of information regarding the cellular and molecular biology of neurodevelopment. Modern tools and classical techniques continue to excavate neurodevelopmental events at an unprecedented cellular and molecular resolution. Here, this Special Issue aims to present emerging research, findings, and methods on the cellular and molecular biology of neurodevelopment.

Original research and review papers dealing with all aspects of the cellular and molecular biology of neurodevelopment are welcome for inclusion in this Special issue of Biomolecules. We invite a variety of research papers that provide insight into neurodevelopmental mechanisms. Manuscripts that describe alterations in cellular and molecular processes, changes caused by pharmacological or toxicological insult, genetic loss or gain of function, or environmental exposures, such as infection, inflammation, and stress, are relevant. Descriptive observations and reviews that focus on the cellular and molecular biology of neurodevelopment are pertinent. Techniques, methods, or scientific approaches that provide insight into neurodevelopment are also warranted.

Dr. David M. Feliciano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neural stem cells
  • neuroblasts
  • neurons
  • glia
  • microglia
  • molecular pathways
  • genes
  • mutations
  • pharmacology
  • toxicology
  • neurodevelopment
  • neurodevelopmental disorders

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

17 pages, 1662 KiB  
Review
TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment
by David M. Feliciano and Angelique Bordey
Biomolecules 2025, 15(4), 573; https://doi.org/10.3390/biom15040573 - 12 Apr 2025
Viewed by 325
Abstract
In restricted regions of the rodent brain, neurogenesis persists throughout life, hinting that perhaps similar phenomena may exist in humans. Neural stem cells (NSCs) that reside within the ventricular-subventricular zone (V-SVZ) continually produce functional cells, including neurons that integrate into the olfactory bulb [...] Read more.
In restricted regions of the rodent brain, neurogenesis persists throughout life, hinting that perhaps similar phenomena may exist in humans. Neural stem cells (NSCs) that reside within the ventricular-subventricular zone (V-SVZ) continually produce functional cells, including neurons that integrate into the olfactory bulb circuitry. The ability to achieve this feat is based on genetically encoded transcriptional programs that are controlled by environmentally regulated post-transcriptional signaling pathways. One such pathway that molds V-SVZ neurogenesis is the mTOR pathway. This pathway integrates nutrient sufficiency with growth factor signaling to control distinct steps of neurogenesis. Alterations in mTOR pathway signaling occur in numerous neurodevelopmental disorders. Here, we provide a narrative review for the role of the mTOR pathway in this process and discuss the use of this region to study the mTOR pathway in both health and disease. Full article
(This article belongs to the Special Issue Cellular and Molecular Biology of Neurodevelopment)
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17 pages, 4261 KiB  
Review
Inhibitor of Growth Proteins: Epigenetic Regulators Shaping Neurobiology
by Ziyue Xu, Hongyu Xu, Jichun Shi, Runming Liu, Xiang Li, Sha Liu and Wei Wei
Biomolecules 2025, 15(2), 281; https://doi.org/10.3390/biom15020281 - 14 Feb 2025
Viewed by 752
Abstract
The inhibitor of growth (ING) family of proteins is emerging as a pivotal regulator of epigenetic modifications within the nervous system. These proteins are involved in various cellular processes, including apoptosis, cell cycle control, and DNA repair, through interactions with chromatin-modifying complexes. Recent [...] Read more.
The inhibitor of growth (ING) family of proteins is emerging as a pivotal regulator of epigenetic modifications within the nervous system. These proteins are involved in various cellular processes, including apoptosis, cell cycle control, and DNA repair, through interactions with chromatin-modifying complexes. Recent studies underscore the dual role of ING proteins in both tumor suppression and neuronal differentiation, development, and neuroprotection. This review summarizes the epigenetic functions of ING proteins in neurobiology, with a focus on their involvement in neural development and their relevance to neuro-oncological diseases. We explore the mechanisms by which ING proteins influence chromatin state and gene expression, highlighting their interactions with histone acetyltransferases, deacetylases, histone methyltransferases, DNA modification enzymes, and non-coding RNAs. A deeper understanding of the role of ING proteins in epigenetic regulation in the nervous system may pave the way for novel therapeutic strategies targeting neurological disorders. Full article
(This article belongs to the Special Issue Cellular and Molecular Biology of Neurodevelopment)
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