Barrier Formation and Homeostasis in the Vertebrate Brain
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 1734
Special Issue Editors
Interests: vasculogenesis and angiogenesis mechanisms in zebrafish and mouse brains; vessel and axon guidance; translational models of disease; cilia biology
Interests: brian endothelium; cilia biology; brain vascular stability; vascular diseases; developmental biology
Interests: translational models of cerebrovascular diseases; cilia biology; cerebrovascular inflammation and homeostasis; TBI; vascular dementia; neurovascular–immune system crosstalk
Special Issue Information
Dear Colleagues,
In this Special Edition, we invite you to submit articles that study the various barriers associated with child and adult brains. One of the key barriers, namely the blood–brain barrier, is associated with preserving tissue homeostasis in the brain, and the deregulation of this barrier is associated with genetic and non-genetic conditions. Other barriers, such as the blood–retinal barrier, blood–lymph barrier and the blood–cerebrospinal fluid barrier, are also equally important, and we welcome studies that investigate these barriers. Studies focused on cell–cell interactions and the mechanisms underlying barrier formation or disruption are welcome. Approaches utilizing 3D microfluidic-based primary cell culture model systems, organoids, induced pluripotent stem cells, zebrafish, rodent model systems and human brain tissue are welcome. Computational modelling studies that mimic and provide novel hypotheses in barrier formation will also be considered. In general, we are interested in a multi-faceted innovative approach to barrier formation in vertebrates, and its role in disease. Endothelial barrier formation in tissues outside the brain will also be considered on a case-by-case basis. Original articles, reviews, hypotheses, and perspectives are welcome. Studies must be focused on basic science using in vitro, in vivo, and pre-clinical models. Manuscripts with exclusive clinical studies will not be considered.
Prof. Dr. Ramani Ramchandran
Dr. Karthikeyan Thirugnanam
Dr. Ankan Gupta
Guest Editors
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Keywords
- brain endothelial cell
- pericytes
- choroid plexus
- retina
- lymphatic
- blood
- astrocytes
- oligodendrocytes
- brain ventricle
- microglia
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