The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1
Special Issue Editor
Interests: gene expression; microRNA (miRNA); leukemia; cancer; COVID-19; vaccines; targeted therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetic modifications, including DNA methylation, histone modifications, and microRNA regulation, have emerged as central players in cancer biology, influencing tumor initiation, progression, and therapeutic resistance. These mechanisms are intricately involved in the reprogramming of gene expression in cancer cells, often leading to the silencing of tumor suppressor genes or the aberrant activation of oncogenes. A comprehensive understanding of these processes is essential for discovering novel diagnostic biomarkers and developing targeted therapies capable of overcoming the limitations of conventional treatments.
This Special Issue aims to provide an in-depth exploration of the complex interactions between DNA methylation, histone modifications, and miRNAs in the context of cancer. We will focus on the molecular mechanisms through which these epigenetic alterations regulate key cellular pathways, including cell cycle control, apoptosis, and DNA repair, all of which are frequently dysregulated in cancer. Furthermore, we seek to emphasize the growing potential of epigenetic reprogramming as a therapeutic strategy, particularly in overcoming drug resistance and improving patient stratification for personalized cancer therapy.
We invite submissions that address recent advancements in understanding how these epigenetic factors contribute to cancer pathophysiology and how they can be harnessed for innovative therapeutic interventions. This issue will serve as a valuable resource for researchers aiming to bridge the gap between fundamental epigenetic research and its clinical applications in oncology.
Dr. Joanna Szczepanek
Guest Editor
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Keywords
- epigenetic regulation
- DNA methylation
- histone modifications
- microRNA
- cancer progression
- therapeutic resistance
- tumor suppressor genes
- oncogenic reprogramming
- personalized cancer therapy
- epigenetic therapy
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