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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Target Antigens to Companion Diagnostics: Antibody-Based Therapies in Women’s Cancers

edited by

Salvatore Cortellino

and

Canio Martinelli

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1063

Keywords: antibody–drug conjugate (ADC); antibody therapy; bispecific antibody; companion diagnostics; biomarker thresholds; immunohistochemistry; FRα; HER2; tissue factor; spatial heterogeneity; tumor penetration; endocytosis/trafficking; bystander effect; resistance mechanisms

(This special issue belongs to the Section Molecular Reproduction)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 20 Aug 2026 | 3 articles | Viewed by 15181 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

submission deadline 20 Aug 2026 | 4 articles | Viewed by 7059 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 20 Aug 2026 | Viewed by 622 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 20 Aug 2026 | Viewed by 550 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

(This special issue belongs to the Section Chemical Biology)

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 20 Aug 2026 | Viewed by 438 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

edited by

Rui Li

and Xinmin Li

submission deadline 20 Aug 2026 | Viewed by 389 | Submission Open

Keywords: multiomics and bioinformatics; functional genomics; molecular breeding; molecular plant biology; functional genomics; sustainable agricultural biotechnology; nutrition and health of functional foods

(This special issue belongs to the Section Molecular Genetics)

Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 25 Aug 2026 | 1 articles | Viewed by 519 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Aug 2026 | Viewed by 834 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Bioactive Compounds in Dermatology

edited by

Gaewon Nam

submission deadline 30 Aug 2026 | 1 articles | Viewed by 396 | Submission Open

Keywords: bioactive compounds; cosmetic active ingredients; dermatology; skin bioengineering; skin biology

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Glycosylation: Cutting-Edge Approach to Targeted Therapy in Cancer

edited by

Myron R. Szewczuk

submission deadline 30 Aug 2026 | Viewed by 260 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 Aug 2026 | 12 articles | Viewed by 31890 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Aug 2026 | 6 articles | Viewed by 15405 | Submission Open

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Aug 2026 | 1 articles | Viewed by 13605 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

New Insights into Cardiometabolic Diseases, 2nd Edition

edited by

Gundu Rao

and

Undurti N. Das

submission deadline 31 Aug 2026 | 2 articles | Viewed by 12171 | Submission Open

Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events

(This special issue belongs to the Section Molecular Medicine)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Aug 2026 | 4 articles | Viewed by 10007 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 Aug 2026 | 4 articles | Viewed by 8249 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6691 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer

edited by Lynn Jeanette Savic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5969 | Submission Open

Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages

(This special issue belongs to the Section Biological Factors)

Iron Metabolism in Cells

edited by

Magdalena Gryzik

and

Michela Asperti

submission deadline 31 Aug 2026 | 5 articles | Viewed by 5685 | Submission Open

Keywords: iron metabolism; iron-related proteins; iron uptake; iron storage; mitochondrial iron metabolism; iron sensing mechanism; ferroptosis

(This special issue belongs to the Section Cellular Biochemistry)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 31 Aug 2026 | 5 articles | Viewed by 5560 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 31 Aug 2026 | 3 articles | Viewed by 4535 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4332 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Extracellular Non-Coding RNAs in Health and Disease

edited by

Arijit Mukhopadhyay

submission deadline 31 Aug 2026 | 3 articles | Viewed by 4162 | Submission Open

Keywords: extracellular vesicles; exosomes; non-coding RNA; microRNA; biomarker

(This special issue belongs to the Section Molecular Biomarkers)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4033 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3726 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3286 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

Regulation of Sperm Function and Embryo Development

edited by

Jacob Thundathil

and

John P. Kastelic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3197 | Submission Open

Keywords: sperm; oocyte; embryo; genes; reproductive technologies

(This special issue belongs to the Section Molecular Reproduction)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2576 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2497 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2083 | Submission Open

Keywords: pigment–protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Mechanistic Insights of Retinal Diseases and Directions for New Therapeutics

edited by

Jing Chen

and Neetu Kushwah

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1305 | Submission Open

Keywords: retinopathy; AMD; retinal degeneration; ocular pharmacology; translational therapeutics

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathogenesis of Cancer Induced by Inflammatory Bowel Disease

edited by Guang-Yu Yang and Senthil Radhakrishnan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1265 | Submission Open

Keywords: cancer; inflammatory bowel disease; genomic; pathogenesis; biomarkers; pathway; therapeutic strategies

(This special issue belongs to the Section Biological Factors)

Application of Bioinformatics in Medicine, 2nd Edition

edited by

Le Zhang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1204 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Glycans in Health and Disease: Molecular Insights and Clinical Implications

edited by

Vaibhav Tiwari

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1011 | Submission Open

Keywords: glycans; glycobiology; proteoglycans; heparan sulfate; infection; pathogen host cell interaction; disease; cancer; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Dynamic Interactions Between Biomolecules: Insights from Bioinformatics and Computational Biology

edited by Jayadev Joshi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 925 | Submission Open

Keywords: biomolecular interactions; molecular dynamics; structural bioinformatics; computational biology; protein interactions; conformational dynamics; machine learning; systems biology; integrative modeling; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Biomarkers of Oxidative and Nitrosative Stress: Mechanisms, Detection, and Clinical Significance

edited by

Narcyz Knap

and

Michał Woźniak

submission deadline 31 Aug 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: oxidative stress; nitrosative stress; reactive oxygen species (ROS); reactive nitrogen species (RNS); lipid peroxidation; ferroptosis; protein oxidation; DNA oxidative modifications; antioxidant defense mechanisms; free radicals; redox signaling; redox biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives, 2nd Edition

edited by Marion Korach-André

submission deadline 31 Aug 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome

(This special issue belongs to the Section Molecular Medicine)

Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Harrys Kishore Charles Jacob

and

John Lalith Charles Richard

submission deadline 31 Aug 2026 | Viewed by 618 | Submission Open

Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics

Metabolic and Signal Transduction Pathways Controlling Platelet and Megakaryocyte Activity

edited by Ana Kasirer-Friede and Deepa Gautam

submission deadline 31 Aug 2026 | Viewed by 590 | Submission Open

Keywords: platelet; megakaryocyte; signaling; omics; immune

(This special issue belongs to the Section Molecular Biology)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 514 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

State of the Art of Myology: 3rd Edition

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2026 | Viewed by 366 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Immunotherapy for Mesothelioma

edited by Licun Wu

submission deadline 31 Aug 2026 | Viewed by 366 | Submission Open

Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Iron Proteins: Molecular Interactions, Structural Characterization and Biomedical Applications

edited by

Georgia C. Papaefthymiou

submission deadline 31 Aug 2026 | Viewed by 339 | Submission Open

Keywords: iron storage (ferritin); iron transport (transferrin, ferroportin); O2 storage (myoglobin); O2 transport (hemoglobin); electron transfer (Fe-S proteins, cytochromes); ferritin degradation; (ferritinophagy); oxidative stress protection (ferritin, Dps proteins); biocompatible iron-oxide nanoparticles; magnetoferritin; biogenic magnetite by magnetotactic bacteria (magnetosomes); iron-based metal–organic frameworks (Fe-MOFs)

(This special issue belongs to the Section Molecular Biology)

Physiological Responses and Biomolecular Adaptations to Environmental and Biotic Stress in Aquatic Species

edited by

Eleni Golomazou

submission deadline 31 Aug 2026 | Viewed by 322 | Submission Open

Keywords: aquaculture; fish pathogens; fish welfare; health protection

(This special issue belongs to the Section Molecular Biology)

From Molecular Mechanisms to Therapeutics: Multidisciplinary Advances in Gene Expression Research

edited by

Cristina Maracci

submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open

Keywords: gene regulation; drug design; computational biology; AI modeling; protein synthesis; gene regulatory network; transcription; post-transcriptional regulation; molecular biology

(This special issue belongs to the Section Molecular Genetics)

Molecular Imaging Biomarkers in Inflammation and Metabolic Disorders

edited by

Uwe Himmelreich

submission deadline 31 Aug 2026 | Viewed by 267 | Submission Open

Keywords: inflammation; metabolic disorders; molecular imaging; metabolism; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms and Therapeutic Strategies in Pediatric Immune Dysregulation

edited by Rita Consolini and

Giorgio Costagliola

submission deadline 31 Aug 2026 | Viewed by 248 | Submission Open

Keywords: immune dysregulation; autoimmunity; inborn errors of immunity; targeted therapies; immunomodulatory treatments; genetics; gene therapy; hematopoietic stem cell transplantation

(This special issue belongs to the Section Molecular Medicine)

The Fibroblast-IL-6 Axis in Skin Cancer Microenvironment

edited by

Lukas Lacina

and

Karel Smetana, Jr.

submission deadline 31 Aug 2026 | Viewed by 219 | Submission Open

Keywords: cancer microenvironment; cancer-associated fibroblasts (CAFs); cancer supporting inflammation; malignant melanoma; non-Melanoma Skin Cancer (NMSC); IL-6 signalling pathway; IL-6 receptor; ageing; senescence associated secretory phenotype (SASP)

(This special issue belongs to the Section Cellular Biochemistry)

Copper Signaling and Redox Biology in Vascular Function and Disease

edited by Archita Das

submission deadline 31 Aug 2026 | Viewed by 199 | Submission Open

Keywords: redox signaling; endothelial cell; vascular biology; angiogenesis; atherosclerosis; diabetes; copper transporter proteins

(This special issue belongs to the Section Molecular Medicine)

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